3-Methyl-3-pyrazolin-5-one
- Product Name
- 3-Methyl-3-pyrazolin-5-one
- CAS No.
- 4344-87-0
- Chemical Name
- 3-Methyl-3-pyrazolin-5-one
- Synonyms
- 3H-Pyrazol-3-one, 1,2-dihydro-5-methyl-;AKOS B028792;3 METHYLPYRAZOLONE;5-Methyl-1H-pyrazole-3-ol;3-METHYL-3-PARAZOLIN-5-ONE;3-METHYL-3-PYRAZOLIN-5-ONE;3-Hydroxy-5-methylpyrazole;3-Methyl-3-pyrazoline-5-one;5-METHYL-3-HYDROXY PYRAZOLE;5-Methyl-1H-pyrazol-3(2H)-one
- CBNumber
- CB8217187
- Molecular Formula
- C4H6N2O
- Formula Weight
- 98.1
- MOL File
- 4344-87-0.mol
3-Methyl-3-pyrazolin-5-one Property
- Melting point:
- 223-225 °C (lit.)
- Density
- 1.107±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- 1 M NH4OH: soluble25mg/mL, clear, colorless (in methanol)
- form
- solid
- pka
- 9.04±0.70(Predicted)
- color
- Off White
- CAS DataBase Reference
- 4344-87-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- HS Code
- 2933119000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 303062
- Product name
- 3-Methyl-3-pyrazolin-5-one
- Purity
- 98%
- Packaging
- 25g
- Price
- $50.1
- Updated
- 2023/06/20
- Product number
- 4H01-1-32
- Product name
- 3-Methyl-5-hydroxypyrazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-W013725
- Product name
- 5-Methyl-1H-pyrazol-3(2H)-one
- Purity
- 98.83%
- Packaging
- 500g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 072859
- Product name
- 3-Methyl-5-hydroxypyrazole
- Purity
- 95+%
- Packaging
- 25g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 072859
- Product name
- 3-Methyl-5-hydroxypyrazole
- Purity
- 95+%
- Packaging
- 100g
- Price
- $49
- Updated
- 2021/12/16
3-Methyl-3-pyrazolin-5-one Chemical Properties,Usage,Production
Chemical Properties
Light yellow crystalline powder
Uses
3-Methyl-3-pyrazolin-5-one was used in the preparation of substituted 4-alkyl(cycloalkyl)-2-amino-3-cyano-4H-pyrans.
General Description
3-Methyl-3-pyrazolin-5-one is an intermediate in the synthesis of heterocyclic compounds. Crystal structure of 3-methyl-3-pyrazolin-5-one was studied.
Synthesis
141-97-9
4344-87-0
GENERAL METHODS: Phenylhydrazine (1 mmol), ethyl acetoacetate (1 mmol) and cobalt doped ZnS nanoparticles (5 mol%) were mixed in a Borosil beaker. The reaction mixture was homogeneously mixed using a glass rod and placed in an infrared reactor (360 W) for irradiation. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature. Subsequently, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent to give the crude product. The crude product was purified by recrystallization from hot ethanol. Nanoparticles were recovered by sonication of the aqueous phase and could be reused four times in the same reaction.
References
[1] Journal of Molecular Catalysis A: Chemical, 2013, vol. 373, p. 61 - 71
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2016, vol. 55B, # 4, p. 507 - 516
[3] Patent: WO2015/200650, 2015, A1. Location in patent: Paragraph 0532-0534
[4] Chemische Berichte, 1896, vol. 29, p. 257
[5] Journal fuer Praktische Chemie (Leipzig), 1889, vol. <2> 39, p. 52
3-Methyl-3-pyrazolin-5-one Preparation Products And Raw materials
Raw materials
Preparation Products
3-Methyl-3-pyrazolin-5-one Suppliers
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
View Lastest Price from 3-Methyl-3-pyrazolin-5-one manufacturers
- Product
- 3-Methyl-3-pyrazolin-5-one 4344-87-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-20