4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid

Product Name: 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
CAS No.: 641569-94-0
Chemical Name: 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
Synonyms: -3-((4-(pyridin-3-yL;Nilotinib EP Impurity D;Nilotinib Intemediate 2;Nilotinib EP Impurity D/B;4-Methyl-3-((4-(pyridin-3-yl);Nilotinib Carboxylic Acid Impurity;Nilotinib Hydrochloride Monohydrate Impurity D;Nilotinib Impurity 6 (Nilotinib EP Impurity D);Nilotinib Hydrochloride Monohydrate EP Impurity D;4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoicaci
CBNumber: CB61503982
Molecular Formula: C17H14N4O2
Formula Weight: 306.32
MOL File: 641569-94-0.mol

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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Property

Melting point:: >257oC (dec.)
Boiling point:: 587.9±60.0 °C(Predicted)
Density: 1.336
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
pka: 4.35±0.10(Predicted)
form: Solid
color: Pale Beige
Stability:: Hygroscopic
InChI: InChI=1S/C17H14N4O2/c1-11-4-5-12(16(22)23)9-15(11)21-17-19-8-6-14(20-17)13-3-2-7-18-10-13/h2-10H,1H3,(H,22,23)(H,19,20,21)
InChIKey: LDLZPHLSVKGFSC-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1
CAS DataBase Reference: 641569-94-0(CAS DataBase Reference)

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: N465305
Product name: 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoicacid
Packaging: 5g
Price: $275
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H21-1-Y0
Product name: 4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid
Packaging: 1g
Price: $133
Updated: 2021/12/16

Apolloscientific

Product number: OR16087
Product name: 4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoicacid
Packaging: 250mg
Price: $15
Updated: 2021/12/16

Apolloscientific

Product number: OR16087
Product name: 4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoicacid
Packaging: 1g
Price: $19
Updated: 2021/12/16

AK Scientific

Product number: J11466
Product name: NilotinibImpurity20
Packaging: 25mg
Price: $39
Updated: 2021/12/16

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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Chemical Properties,Usage,Production

Uses

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is used in the preparation of (pyridinyl)-N-[(triazolyl)phenyl]pyrimidinamine derivatives and (pyridinyl)-N-[oxadiazolyl)phenyl]pyrimidinamine derivatives, and can be used in the detection of their activity as antileukemia agents (neoplastic stem cell leukemia). 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is also a Nilotinib (N465300) intermediate, which might be useful in treatment of chronic myelogenous leukemia.

Synthesis

3- [(Aminoiminomethyl)amino] -4-methyl-benzoic acid methyl ester mononitrate (10 g),3-(Dimethylamino)-1-(pyridine-3-yl)prop-2-en-1-one (7.3 g), sodium hydroxide (1.7 g) was added to 1-butanol (100 mL) in a round bottom flask under nitrogen atmosphere. The reaction mass was heated to reflux temperature and stirred for 12 hours. Then the reaction mass was cooled to 25-35°C, and iN sodium hydroxide solution (1.5 g in 37 mL of DM water) was added to it throughout 20 mm. The reaction mass was heated to reflux temperature (120-125°C) and then cooled to 25-35°C. Hydrochloric acid was added to the reaction mass at 25-35°C and stirred for an hour. The material formed was filtered, washed with DM water and then dried under vacuum at 50-55°C to provide 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid (8.7 g).

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Suppliers

China 233 India 18 United Kingdom 1 United States 10 Global 262

Yangzhou QinYuan Pharmaceutical Co., Ltd.

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View Lastest Price from 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid manufacturers

Nanjing Fred Technology Co., Ltd

Product: 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 641569-94-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-20

Henan Fengda Chemical Co., Ltd

Product: 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 641569-94-0
Price: US $10.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-28

LY Global chemicals co.,ltd .

Product: 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 641569-94-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.0%min
Supply Ability: 100kg
Release date: 2023-03-11

641569-94-0, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acidRelated Search:

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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid

Nilotinib EP Impurity D

4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid

Benzoic acid, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-

4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidiny]aMino]benzoic acid

2-[(5-Carboxy-2-methylphenyl)amino]-4-(pyridin-3-yl)pyrimidine, 3-{2-[(5-Carboxy-2-methylphenyl)amino]pyrimidin-4-yl}pyridine

Nilotinib Intemediate 2

4-Methyl-3-((4-(pyridin-3-yl)

Nilotinib Carboxylic Acid Impurity

-3-((4-(pyridin-3-yL

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid(For export only)

Nilotinib EP Impurity D/B

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic aci...

3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylbenzoic acid

4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoicaci

Nilotinib Hydrochloride Monohydrate Impurity D

Nilotinib Impurity 6 (Nilotinib EP Impurity D)

Nilotinib Hydrochloride Monohydrate EP Impurity D

4-Methyl-3-[[4-G-pyridinyl)-2-pyrimidinyl]amino] benzoic acid

641569-94-0

641589-94-0