3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Product Name: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
CAS No.: 641571-11-1
Chemical Name: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
Synonyms: NILOTINIB IMPURITY 24;Nilotinib EP Impurity A;Nilotinib Intemediate 1;Nilotinib Amino Impurity;Nilotinib??Intermediates?A;Nilotinib genotoxic impurity 1;Nilotinib Hydrochloride Monohydrate Impurity A;Nilotinib Impurity 15(Nilotinib EP Impurity A);3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl);Nilotinib Hydrochloride Monohydrate EP Impurity A
CBNumber: CB91503963
Molecular Formula: C11H10F3N3
Formula Weight: 241.21
MOL File: 641571-11-1.mol

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3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Property

Melting point:: 124-126°C
Boiling point:: 372.14℃[at 101 325 Pa]
Density: 1.35
vapor pressure: 0Pa at 25℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder to crystal
color: White to Light gray to Light yellow
Water Solubility: 228.6mg/L at 25℃
InChI: InChI=1S/C11H10F3N3/c1-7-5-17(6-16-7)10-3-8(11(12,13)14)2-9(15)4-10/h2-6H,15H2,1H3
InChIKey: WWTGXYAJVXKEKL-UHFFFAOYSA-N
SMILES: C1(N2C=C(C)N=C2)C=C(N)C=C(C(F)(F)F)C=1
LogP: 2.42
CAS DataBase Reference: 641571-11-1(CAS DataBase Reference)

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Safety

Risk Statements: 41
Safety Statements: 26-39
RIDADR: 2811
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 2933299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: VBP00135
Product name: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
Packaging: 1g
Price: $482
Updated: 2024/03/01

TCI Chemical

Product number: M2634
Product name: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $33
Updated: 2024/03/01

TCI Chemical

Product number: M2634
Product name: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $109
Updated: 2024/03/01

TRC

Product number: M313065
Product name: 3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline
Packaging: 25mg
Price: $145
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-3-T2
Product name: 3-Amino-5-(4-methyl-1H-imidazol-1-yl)benzotrifluoride
Packaging: 250mg
Price: $150
Updated: 2021/12/16

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3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Chemical Properties,Usage,Production

Description

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is a pharmaceutical intermediate component used in the preparation of Nilotinib for the treatment of a variety of leukaemias, including chronic myeloid leukaemia (CML).

Chemical Properties

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is a white to light grey to light yellow powder to crystals with a melting point of 130 °C.

Uses

Intermediate in the preparation of Nilotinib.

Application

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is an arylimidazole derivative. This compound includes multiple functional groups: aniline, methyl, and imidazole. Hence, the compound is readily available for further functionalization. This building block can typically synthesize homoleptic imidazole-type iridium (Ir) triplet emitters as a blue phosphorescent emitter in OLED. The iridium organometallic complex is formed by coordinating the imidazole and the aryl group to the iridium metal center. The trifluoromethyl group, with a strong electron-withdrawing effect, increases the energy gap between the highest occupied molecular orbital and the lowest unoccupied molecular orbital (HOMO-LUMO), hence enabling a blue shift in the photoluminescent emission[1].

References

[1] Qiang Wei. “Small-Molecule Emitters with High Quantum Efficiency: Mechanisms, Structures, and Applications in OLED Devices.” Advanced Optical Materials 6 20 (2018).

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Suppliers

Americas 1 Canada 3 China 275 Europe 1 Germany 1 India 40 Japan 2 United Kingdom 5 United States 23 Global 351

Yangzhou QinYuan Pharmaceutical Co., Ltd.

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View Lastest Price from 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 641571-11-1
Price: US $35.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-28

Nanjing Fred Technology Co., Ltd

Product: 3-(4-Methyl-1H-Imidazol-1-yl)-5-(Trifluoromethyl)Aniline 641571-11-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-20

LY Global chemicals co.,ltd .

Product: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 641571-11-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.0%min
Supply Ability: 100kg
Release date: 2023-03-11

641571-11-1, 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)anilineRelated Search:

Tris(hydroxymethyl)aminomethane Methyl acrylate Methylparaben METSULFURON METHYL ALTRENOGEST 3,3',5,5'-Tetramethylbenzidine dihydrochloride Acid Blue 93 o-Toluidine Bensulfuron methyl Aniline Glycine N-Methylaniline N,N-Dimethyl-1,4-phenylenediamine Methyl cellulose 1-Methylimidazole N,N-Dimethylaniline 3-Amino-5-bromobenzotrifluoride Nilotinib N-Oxide

1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(4-Methyl-1-imidazolyl)-5-(trifluoromethyl)aniline

Nilotinib EP Impurity A

NILOTINIB IMPURITY 24

4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl) benzene amine

3-(trifluoromethyl)-5-(4-methyl-1H-imidazol-1-yl)benzenamine

3-(4-Methyl-iMidazol-1-yl)-5-trifluoro-MethylphenylaMine

3-Amino-5-(4-methyl-1H-imidazol-1-yl)benzotrifluoride

3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine

3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzeneaMine, 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)aniline

BenzenaMine, 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)-

3-(4-Methyl-iMidazole-1-yl)-5-trifluoro MethylphenylaMine

5-(4-Methyl-1H-iMidazol-1-yl)-3-(trifluoroMethyl)-BenzeneaMine

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole

Nilotinib genotoxic impurity 1

3-(4-Methyl-1<i>H</i>-imidazol-1-yl)-5-(trifluoromethyl)aniline

Nilotinib Intemediate 1

Nilotinib Amino Impurity

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline &gt

Nilotinib Related Compound A USP Impurity Certified Reference Standard

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoro methyl)benzamine

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline(For export only)

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline ISO 9001：2015 REACH

3-(4-Methyl-1H-imidazol-1-yl)-5- (trifluoromethyl)aniline(Nilotinib EP Impurity A)

Nilotinib??Intermediates?A

Nilotinib Hydrochloride Monohydrate Impurity A

5-(4-Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)benzenamine

Nilotinib Impurity 15(Nilotinib EP Impurity A)

3-(4-Methyl-1H-Imidazol-1-yl)-5-(Tri?uoromethyl)Aniline

5-(4-Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-aniline

5- (4-methyl-1H-Imidazol-1-yl)3- (trifluoromethy benzenamine

Nilotinib Hydrochloride Monohydrate EP Impurity A

641571-11-1

541571-11-1

Nilotinib/Tasigna

Amines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals