ChemicalBook > CAS DataBase List > 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid

Product Name
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
CAS No.
641569-94-0
Chemical Name
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
Synonyms
-3-((4-(pyridin-3-yL;Nilotinib EP Impurity D;Nilotinib Intemediate 2;Nilotinib EP Impurity D/B;4-Methyl-3-((4-(pyridin-3-yl);Nilotinib Carboxylic Acid Impurity;Nilotinib Hydrochloride Monohydrate Impurity D;Nilotinib Impurity 6 (Nilotinib EP Impurity D);Nilotinib Hydrochloride Monohydrate EP Impurity D;4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoicaci
CBNumber
CB61503982
Molecular Formula
C17H14N4O2
Formula Weight
306.32
MOL File
641569-94-0.mol
More
Less

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Property

Melting point:
>257oC (dec.)
Boiling point:
587.9±60.0 °C(Predicted)
Density 
1.336
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
4.35±0.10(Predicted)
form 
Solid
color 
Pale Beige
Stability:
Hygroscopic
InChI
InChI=1S/C17H14N4O2/c1-11-4-5-12(16(22)23)9-15(11)21-17-19-8-6-14(20-17)13-3-2-7-18-10-13/h2-10H,1H3,(H,22,23)(H,19,20,21)
InChIKey
LDLZPHLSVKGFSC-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1
CAS DataBase Reference
641569-94-0(CAS DataBase Reference)
More
Less

Safety

HS Code 
2933599590
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

TRC
Product number
N465305
Product name
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoicacid
Packaging
5g
Price
$275
Updated
2021/12/16
Apolloscientific
Product number
OR16087
Product name
4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoicacid
Packaging
250mg
Price
$15
Updated
2021/12/16
Apolloscientific
Product number
OR16087
Product name
4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoicacid
Packaging
1g
Price
$19
Updated
2021/12/16
AK Scientific
Product number
J11466
Product name
NilotinibImpurity20
Packaging
25mg
Price
$39
Updated
2021/12/16
SynQuest Laboratories
Product number
4H21-1-Y0
Product name
4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid
Packaging
250mg
Price
$77
Updated
2021/12/16
More
Less

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Chemical Properties,Usage,Production

Uses

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is used in the preparation of (pyridinyl)-N-[(triazolyl)phenyl]pyrimidinamine derivatives and (pyridinyl)-N-[oxadiazolyl)phenyl]pyrimidinamine derivatives, and can be used in the detection of their activity as antileukemia agents (neoplastic stem cell leukemia). 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is also a Nilotinib (N465300) intermediate, which might be useful in treatment of chronic myelogenous leukemia.

Synthesis

3- [(Aminoiminomethyl)amino] -4-methyl-benzoic acid methyl ester mononitrate (10 g),3-(Dimethylamino)-1-(pyridine-3-yl)prop-2-en-1-one (7.3 g), sodium hydroxide (1.7 g) was added to 1-butanol (100 mL) in a round bottom flask under nitrogen atmosphere. The reaction mass was heated to reflux temperature and stirred for 12 hours. Then the reaction mass was cooled to 25-35°C, and iN sodium hydroxide solution (1.5 g in 37 mL of DM water) was added to it throughout 20 mm. The reaction mass was heated to reflux temperature (120-125°C) and then cooled to 25-35°C. Hydrochloric acid was added to the reaction mass at 25-35°C and stirred for an hour. The material formed was filtered, washed with DM water and then dried under vacuum at 50-55°C to provide 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid (8.7 g).

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Suppliers

China 236 India 17 United Kingdom 1 United States 10 Global 264
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Fragmenta
Tel
--
Fax
--
Email
sales@fragmenta.com
Country
United States
ProdList
1068
Advantage
0
More
Less

View Lastest Price from 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 641569-94-0
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-13
Nanjing Fred Technology Co., Ltd
Product
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 641569-94-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-20
Henan Fengda Chemical Co., Ltd
Product
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 641569-94-0
Price
US $10.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-28

641569-94-0, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acidRelated Search:

4-Dimethylaminobenzoic acid Methyl acrylate 4-Aminobenzoic acid Glycine Methyl cellulose Bensulfuron methyl METSULFURON METHYL Methylparaben Benzoic acid, 4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]- Methyl 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 4-(pyridine-2-yl) pyrimidin-2-amine Nilotinib N-Oxide 3-Amino-5-bromobenzotrifluoride 3-Iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide Nilotinib impurity 3 Nilotinib Impurity 28

  • 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
  • Nilotinib EP Impurity D
  • 4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid
  • Benzoic acid, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-
  • 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidiny]aMino]benzoic acid
  • 2-[(5-Carboxy-2-methylphenyl)amino]-4-(pyridin-3-yl)pyrimidine, 3-{2-[(5-Carboxy-2-methylphenyl)amino]pyrimidin-4-yl}pyridine
  • Nilotinib Intemediate 2
  • 4-Methyl-3-((4-(pyridin-3-yl)
  • Nilotinib Carboxylic Acid Impurity
  • -3-((4-(pyridin-3-yL
  • 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid(For export only)
  • Nilotinib EP Impurity D/B
  • 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic aci...
  • 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylbenzoic acid
  • 4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoicaci
  • Nilotinib Hydrochloride Monohydrate Impurity D
  • Nilotinib Impurity 6 (Nilotinib EP Impurity D)
  • Nilotinib Hydrochloride Monohydrate EP Impurity D
  • 4-Methyl-3-[[4-G-pyridinyl)-2-pyrimidinyl]amino] benzoic acid
  • 641569-94-0
  • 641589-94-0