5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine

Product Name: 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine
CAS No.: 799842-07-2
Chemical Name: 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine
Synonyms: Z8;Rosuvastatin Z-8;Rosuvastatin Impurity 103;Rosuvastatin Impurity 079;Rosuvastatin Intermediate Z8;rosuvastatin intermediates Z-8;Rosuvastatin Bromomethyl Impurity;： 5-(BroMoMethyl)-4-(4-fluorophenyl)-6-isopropyl-2;5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(met...;N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-
CBNumber: CB61508639
Molecular Formula: C16H19BrFN3O2S
Formula Weight: 416.31
MOL File: 799842-07-2.mol

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5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine Property

Boiling point:: 531.2±60.0 °C(Predicted)
Density: 1.466
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.77±0.10(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 799842-07-2(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: B847058
Product name: 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine
Packaging: 100mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB148744
Product name: 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine
Packaging: 100mg
Price: $124
Updated: 2021/12/16

AK Scientific

Product number: W8519
Product name: N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethanesulfonamide
Packaging: 10g
Price: $131
Updated: 2021/12/16

Matrix Scientific

Product number: 090821
Product name: N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropropyl-pyrimidine-2-yl]-N-methylmethane sulfonamide
Purity: 95+%
Packaging: 5g
Price: $198
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB148744
Product name: 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine
Packaging: 250mg
Price: $247.5
Updated: 2021/12/16

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5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine Chemical Properties,Usage,Production

Uses

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine is an impurity of Rosuvastatin (R700500), which is a selective, competitive HMG-CoA reductase inhibitor.

Synthesis

925422-06-6

799842-07-2

General procedure for the synthesis of 5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidines from compound (CAS:925422-06-6): 1. N-[5-hydroxymethyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide (50.0 g) and 48% aqueous hydrogen bromide solution (130.0 mL) were added to the reactor. 2. The reaction mixture was stirred at 80 °C for 15 h. The progress of the reaction was monitored by thin-layer chromatography (unfolding agent: ethyl acetate/hexane=1:2). 3. Upon completion of the reaction, the mixture was cooled to 20 °C and stirring was continued for 1 h at this temperature. 4. The product was collected by filtration under reduced pressure and the resulting white solid was washed with deionized water (500.0 mL). 5. The washed solid was dried under reduced pressure to afford N-[5-bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide as a white solid (55.3 g, 94% yield). 6. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3) with the following chemical shifts (ppm): 1.35 (d, 6H), 3.48 (m, 1H), 3.49 (s, 3H), 3.56 (s, 3H), 4.48 (q, 2H), 7.23 (t, 2H), 7.81 (q, 2H).

References

[1] Patent: WO2012/2741, 2012, A2. Location in patent: Page/Page column 19

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine Suppliers

China 143 India 7 United Kingdom 1 United States 9 Global 160

KKyemistry (India) Pvt. Ltd.

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Trignokem International

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View Lastest Price from 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide 799842-07-2
Price: US $22.00-88.00/kg
Min. Order: 50kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-06-25

Hangzhou ICH Biofarm Co., Ltd

Product: N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide 799842-07-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200
Release date: 2023-07-11

Xinxiang Hongqi District Houyuan Trading Co.,Ltd

Product: 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine 799842-07-2
Price: US $30.00-28.00/Kg
Min. Order: 1Kg
Purity: 99.0% up
Supply Ability: 50 tons per month
Release date: 2022-11-02

799842-07-2, 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidineRelated Search:

Methanol Methylparaben N-Acetylsulfanilyl chloride 3,4'-DIAMINODIPHENYLMETHANE Methyl acrylate Isopropyl alcohol Basic Violet 1 Lithium diisopropylamide ISOPROPYL LAURATE Isopropyl acetate Kresoxim-methyl Sulfanilamide Acetonitrile Methyl Phosphonium, [[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]me Rosuvastatin Impurity 65 Rosuvastatin ethyl ester Rosuvastatin Impurity 81

Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-Methyl-N-MethylsulfonylaMino)PyriMidine PRODUCT:CheMical naMe:Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-Methyl-N-MethylsulfonylaMino)PyriMidine

5-(BROMOMETHYL)-4(FLUOROPHENYL)6-ISOPROPYL-2METHYL(METHYLSULFONYL ) AMINOPYRIMIDINE

5-(Bromomethyl)-4-(4-Fluorophenyl)-6-Isopropyl-3-[Methyl(Methylsulfonyl)Amino]Pyrimidine 98%

Rosuvastatin Impurity 103

Rosuvastatin Z-8

Rosuvastatin Impurity 079

N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropropyl-pyrimidine-2-yl]-N-methylmethane sulfonamide

MethanesulfonaMide, N-[5-(broMoMethyl)-4-(4-fluorophenyl)-6-(1-Methylethyl)-2-pyriMidinyl]-N-Methyl-

Z8

Rosuvastatin Bromomethyl Impurity

rosuvastatin intermediates Z-8

N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropropyl-pyrimidine-2-yl]-N-methylmethane sulfonamid

N-(4-(4-Fluorophenyl)-5-bromomethyl-6- isopropylpyrimidin-2-yl)-N-methyl methane sulfonamide

N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamid

N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methyl methane sulfonamide

： 5-(BroMoMethyl)-4-(4-fluorophenyl)-6-isopropyl-2

4-(4-Fluorophenyl)-5-broMineMethyl-6-Isopropyl-2-(N-Methyl-N-MethylsulfonylaMino)PyriMidine

N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine

N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-Methyl-N-Methylsulfonylamino)Pyrimidine

Chemical name:Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-Methyl-N-Methylsulfonylamino)Pyrimidine

5-Bromomethyl 4 Flurophenyl 6-Isopropyl 2 Methyl Methyl Sulf Onyl Amino Pyrimidine

5-(Bromomethyl)-4-(4-Fluorophenyl)-6-Isopropyl-2 -[(N-Methyl-N-Methylsulfonyl)Amino]Pyrimidine

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(met...

Rosuvastatin Intermediate Z8

N-(5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide? (Rosuvastatin Impurity）

N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-

N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide (BRO-Z7 )

5-(Bromomethyl)-4-(4-Fluorophenyl)-6-Isopropyl-2-[Methyl(Methylsulfonyl)Amino]Pyrimidine 95%

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidine, 98.5%min

799842-07-2

799842-07-3

C16H19BrFN3O2S

Fluorine series

pyrimidine

rosuvastatin intermediates