Drinabant

Product Name: Drinabant
CAS No.: 358970-97-5
Chemical Name: Drinabant
Synonyms: AVE-1625;drinabant;N-[1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl]-N-(3,5-difluorophenyl)methanesulfonamide;Methanesulfonamide, N-[1-[bis(4-chlorophenyl)methyl]-3-azetidinyl]-N-(3,5-difluorophenyl)-
CBNumber: CB61518506
Molecular Formula: C23H20Cl2F2N2O2S
Formula Weight: 497.38
MOL File: 358970-97-5.mol

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Drinabant Property

Boiling point:: 581.7±60.0 °C(Predicted)
Density: 1.458
storage temp.: Store at -20°C
solubility: ≤0.15mg/ml in ethanol;15mg/ml in DMSO;15mg/ml in dimethyl formamide
form: crystalline solid
pka: 5.44±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10009021
Product name: AVE-1625
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 10009021
Product name: AVE-1625
Purity: ≥98%
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 10009021
Product name: AVE-1625
Purity: ≥98%
Packaging: 10mg
Price: $477
Updated: 2024/03/01

Tocris

Product number: 6763
Product name: AVE1625
Purity: ≥98%(HPLC)
Packaging: 10
Price: $243
Updated: 2021/12/16

TRC

Product number: A794723
Product name: AVE-1625
Packaging: 2.5mg
Price: $110
Updated: 2021/12/16

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Drinabant Chemical Properties,Usage,Production

Description

The central cannabinoid (CB₁) receptor is a G protein-coupled receptor that is widely distributed in the central nervous system and several peripheral tissues and binds the active component of cannabis, Δ⁹-tetrahydrocannabinol. Signaling through the CB₁ receptor is implicated in attentional and working memory deficits as well as obesity. AVE-1625 is a highly potent, selective antagonist for the CB₁ receptor with K_i values of 0.16-0.44 nM. At 1-3 mg/kg, AVE-1625 significantly improves the performance of rodents in working memory tasks. At 30 mg/kg, AVE-1625 reduces caloric intake by more than 50% of controls and significantly increases lipolysis from fat tissues and reduces hepatic glycogen levels in rodents.

Uses

AVE-1625 is a selective antagonist for the CB1 receptor.

storage

Store at -20°C

References

[1] borowsky b, stevens r, mark b, et al. ave1625, a cannabinoid cbi antagonist, as a co-treatment for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side effects in animal models[c]//neuropsychopharmacology. macmillan building, 4 crinan st, london n1 9xw, england: nature publishing group, 2005, 30: s116-s117.
[2] herkenham m, lynn a b, little m d, et al. cannabinoid receptor localization in brain[j]. proceedings of the national academy of sciences, 1990, 87(5): 1932-1936.
[3] herling a w, gossel m, haschke g, et al. cb1 receptor antagonist ave1625 affects primarily metabolic parameters independently of reduced food intake in wistar rats[j]. american journal of physiology-endocrinology and metabolism, 2007, 293(3): e826-e832.

Drinabant Preparation Products And Raw materials

Raw materials

Preparation Products

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Drinabant Suppliers

China 23 United States 6 USA 1 Global 30

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49391
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

Suzhou Meishi Biotechnology Co., Ltd.

Tel: 1173954148q
Email: meishipharma@126.com
Country: China
ProdList: 20035
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 4030
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 8740
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12007
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52927
Advantage: 58

358970-97-5, DrinabantRelated Search:

Methylparaben Methanol Dichloromethylphenylsilane Paraquat dichloride Hexamethyldisilazane Basic Violet 1 Methyl acrylate Methyl acetate 1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE N-Methyl-2-pyrrolidone Acetonitrile Kresoxim-methyl Trimethylphenylammonium chloride Methyltriphenylphosphonium bromide Methyl 1-(Diphenylmethyl)-3-azetidinamine dihydrochloride 1-METHYL-AZETIDIN-3-YLAMINE DIHYDROCHLORIDE Drinabant

drinabant

N-[1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl]-N-(3,5-difluorophenyl)methanesulfonamide

AVE-1625

Methanesulfonamide, N-[1-[bis(4-chlorophenyl)methyl]-3-azetidinyl]-N-(3,5-difluorophenyl)-

358970-97-5

C23H20Cl2F2N2O2S