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Drinabant

Product Name
Drinabant
CAS No.
358970-97-5
Chemical Name
Drinabant
Synonyms
AVE-1625;drinabant;N-[1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl]-N-(3,5-difluorophenyl)methanesulfonamide;Methanesulfonamide, N-[1-[bis(4-chlorophenyl)methyl]-3-azetidinyl]-N-(3,5-difluorophenyl)-
CBNumber
CB61518506
Molecular Formula
C23H20Cl2F2N2O2S
Formula Weight
497.38
MOL File
358970-97-5.mol
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Drinabant Property

Boiling point:
581.7±60.0 °C(Predicted)
Density 
1.458
storage temp. 
Store at -20°C
solubility 
≤0.15mg/ml in ethanol;15mg/ml in DMSO;15mg/ml in dimethyl formamide
form 
crystalline solid
pka
5.44±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10009021
Product name
AVE-1625
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
10009021
Product name
AVE-1625
Purity
≥98%
Packaging
5mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
10009021
Product name
AVE-1625
Purity
≥98%
Packaging
10mg
Price
$477
Updated
2024/03/01
Tocris
Product number
6763
Product name
AVE1625
Purity
≥98%(HPLC)
Packaging
10
Price
$243
Updated
2021/12/16
TRC
Product number
A794723
Product name
AVE-1625
Packaging
2.5mg
Price
$110
Updated
2021/12/16
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Drinabant Chemical Properties,Usage,Production

Description

The central cannabinoid (CB1) receptor is a G protein-coupled receptor that is widely distributed in the central nervous system and several peripheral tissues and binds the active component of cannabis, Δ9-tetrahydrocannabinol. Signaling through the CB1 receptor is implicated in attentional and working memory deficits as well as obesity. AVE-1625 is a highly potent, selective antagonist for the CB1 receptor with Ki values of 0.16-0.44 nM. At 1-3 mg/kg, AVE-1625 significantly improves the performance of rodents in working memory tasks. At 30 mg/kg, AVE-1625 reduces caloric intake by more than 50% of controls and significantly increases lipolysis from fat tissues and reduces hepatic glycogen levels in rodents.

Uses

AVE-1625 is a selective antagonist for the CB1 receptor.

in vivo

AVE1625 (10 mg/kg orally once daily), combined with Olanzapine (HY-14541) attenuates body weight gain, diminishing the enhanced food intake while maintaining increased energy expenditure and decreased motility[2].
AVE1625 (1, 3, and 10 mg/kg ip), reverses abnormally persistent LI induced by MK-801 (HY-15084B) or neonatal nitric oxide synthase inhibition in rodents, and improves both working and episodic memory[3].

Animal Model:Rats[1].
Dosage:30 mg/kg.
Administration:Oral gavage, single dose.
Result:Had free access to food during the preceding night (postprandial state) caused a pronounced reduction of food intake during the subsequent 10-12 h without differences in their locomotor activity relative to that of the control group.
Caused an increase in FFA and glycerol, indicating increased lipolysis from fat tissue.
Immediately resulted in a pronounced increase in VCO2 and VO2, indicating increased oxidation of energetic substrates and increased TEE.
Animal Model:Female Hanover Wistar rats weighing 225 ± 8.6 g[2].
Dosage:10 mg/kg.
Administration:Orally once daily.
Result:Reduced their weight markedly within the first 3 days of treatment where upon animals maintained lower body weight, although they lost about 7.3 ± 1.3 g fat during the 12 days of treatment.

IC 50

hCB1-R: 25 nM (IC50); rCB1-R: 10 nM (IC50); CB2: 10000 nM (IC50)

storage

Store at -20°C

References

[1] borowsky b, stevens r, mark b, et al. ave1625, a cannabinoid cbi antagonist, as a co-treatment for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side effects in animal models[c]//neuropsychopharmacology. macmillan building, 4 crinan st, london n1 9xw, england: nature publishing group, 2005, 30: s116-s117.
[2] herkenham m, lynn a b, little m d, et al. cannabinoid receptor localization in brain[j]. proceedings of the national academy of sciences, 1990, 87(5): 1932-1936.
[3] herling a w, gossel m, haschke g, et al. cb1 receptor antagonist ave1625 affects primarily metabolic parameters independently of reduced food intake in wistar rats[j]. american journal of physiology-endocrinology and metabolism, 2007, 293(3): e826-e832.

Drinabant Preparation Products And Raw materials

Raw materials

Preparation Products

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Drinabant Suppliers

China 38 United States 6 USA 1 Global 45
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
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China
ProdList
11218
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58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
NANJING TOMMLAB PHARMATECH Co.,LTD
Tel
--
Fax
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Email
litianang@caremo.com.cn
Country
China
ProdList
483
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Suzhou Meishi Biotechnology Co., Ltd.
Tel
1173954148q
Email
meishipharma@126.com
Country
China
ProdList
20033
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
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China
ProdList
5929
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58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
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China
ProdList
11973
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58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
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58
Shanghai Fine Biotech Co.，Ltd
Tel
18221172427
Email
sale@fine-biotech.com
Country
China
ProdList
2745
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58

358970-97-5, DrinabantRelated Search:

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  • drinabant
  • N-[1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl]-N-(3,5-difluorophenyl)methanesulfonamide
  • AVE-1625
  • Methanesulfonamide, N-[1-[bis(4-chlorophenyl)methyl]-3-azetidinyl]-N-(3,5-difluorophenyl)-
  • 358970-97-5
  • C23H20Cl2F2N2O2S