1-BENZYL-3-OXOAZEPANE
- Product Name
- 1-BENZYL-3-OXOAZEPANE
- CAS No.
- 146407-32-1
- Chemical Name
- 1-BENZYL-3-OXOAZEPANE
- Synonyms
- -azepan-3-one;1-Benzyl-3-azepanone;1-BENZYL-3-OXOAZEPANE;Hexahydro-1-(phenylmethyl)-3H-azepin-3-one;3H-Azepin-3-one, hexahydro-1-(phenylmethyl)-
- CBNumber
- CB61519169
- Molecular Formula
- C13H17NO
- Formula Weight
- 203.28
- MOL File
- 146407-32-1.mol
1-BENZYL-3-OXOAZEPANE Property
- Boiling point:
- 312.6±35.0 °C(Predicted)
- Density
- 1.069±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 6.50±0.20(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B230805
- Product name
- 1-Benzyl-azepan-3-one
- Packaging
- 50mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4461AD
- Product name
- 1-Benzyl-azepan-3-one
- Packaging
- 250mg
- Price
- $188
- Updated
- 2021/12/16
- Product number
- 101755
- Product name
- 1-Benzyl-azepan-3-one
- Purity
- 95%
- Packaging
- 500mg
- Price
- $262
- Updated
- 2021/12/16
- Product number
- 4461AD
- Product name
- 1-Benzyl-azepan-3-one
- Packaging
- 1g
- Price
- $404
- Updated
- 2021/12/16
- Product number
- 101755
- Product name
- 1-Benzyl-azepan-3-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $420
- Updated
- 2021/12/16
1-BENZYL-3-OXOAZEPANE Chemical Properties,Usage,Production
Synthesis
765940-56-5
146407-32-1
The general procedure for the synthesis of 1-benzyl-azepan-3-one from the compound (CAS: 765940-56-5) is as follows: potassium tert-butoxide (336 mg) was suspended in toluene (2.5 mL) and heated under reflux conditions for 10 min. Subsequently, 5-(benzyl-ethoxycarbonylmethyl-amino)-pentanoic acid (695 mg) dissolved in toluene (1 mL) was slowly added to the suspension, and the addition process lasted for 5 hours, after which the reaction was continued at reflux. Upon completion of the reaction, it was cooled to room temperature and acidified by the addition of 25% hydrochloric acid (1 mL). The organic phase was separated and washed with 25% hydrochloric acid (4 x 1 mL). The aqueous hydrochloric acid phase was combined and heated under reflux conditions for 5 hours. After cooling to room temperature, the pH was adjusted to 11 with 2N sodium hydroxide solution to make the solution basic, followed by extraction with ethyl acetate. The organic phases were combined, dried with sodium sulfate and the solvent was evaporated. The resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/heptane, 1:5) to afford the target product 1-benzyl-azepan-3-one (197 mg) in 45% yield. Ref: Bull. Chem. Soc. Jpn. 1956, 29, 631-632; DE2206385.
References
[1] Patent: WO2004/83218, 2004, A1. Location in patent: Page 58
1-BENZYL-3-OXOAZEPANE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-BENZYL-3-OXOAZEPANE manufacturers
- Product
- 1-Benzyl-3-oxoazepane 146407-32-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1-BENZYL-3-OXOAZEPANE 146407-32-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20