6-NITRO-ISOINDOLIN-1-ONE
Uses- Product Name
- 6-NITRO-ISOINDOLIN-1-ONE
- CAS No.
- 110568-64-4
- Chemical Name
- 6-NITRO-ISOINDOLIN-1-ONE
- Synonyms
- 6-Nitro-1-isoindolinone;6-Nitroisoindoline-1-one;6-NITRO-ISOINDOLIN-1-ONE;Benzene,1,5-bis(decyloxy)-;6-Nitro-2,3-dihydro-isoindol-1-one;6-nitro-2,3-dihydro-1H-isoindol-1-one;1H-Isoindol-1-one, 2,3-dihydro-6-nitro-
- CBNumber
- CB61560242
- Molecular Formula
- C8H6N2O3
- Formula Weight
- 178.14
- MOL File
- 110568-64-4.mol
6-NITRO-ISOINDOLIN-1-ONE Property
- Melting point:
- 253 °C (decomp)
- Boiling point:
- 487.5±45.0 °C(Predicted)
- Density
- 1.449±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.56±0.20(Predicted)
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N900708
- Product name
- 6-Nitroisoindolin-1-one
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- N900708
- Product name
- 6-Nitroisoindolin-1-one
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR305291
- Product name
- 6-Nitro-2,3-dihydro-1H-isoindol-1-one
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 4H54-1-09
- Product name
- 6-Nitro-2,3-dihydro-1H-isoindol-1-one
- Purity
- 98%
- Packaging
- 250mg
- Price
- $103
- Updated
- 2021/12/16
- Product number
- CS-W005623
- Product name
- 6-Nitroisoindolin-1-one
- Purity
- >98.0%
- Packaging
- 1g
- Price
- $103
- Updated
- 2021/12/16
6-NITRO-ISOINDOLIN-1-ONE Chemical Properties,Usage,Production
Uses
6-Nitroisoindoline-1-one is a heterocyclic derivative that can be used as a pharmaceutical intermediate. It exists in a variety of natural products and pharmaceutical molecules and has extremely high biological activity.
Synthesis
133446-99-8
110568-64-4
General procedure for the synthesis of 6-nitro-isoindolin-1-one from methyl 2-(bromomethyl)-4-nitrobenzoate: Methyl 2-(bromomethyl)-4-nitrobenzoate (250 mg, 0.92 mmol) was added to a methanolic solution of saturated ammonia (5 mL) and stirred for 2 hr at room temperature, and completion of the reaction was monitored by thin layer chromatography (TLC). The solvent was removed by distillation under reduced pressure and ethyl acetate (7 mL) was added to the residue and sonicated for 3 min, followed by placement in a refrigerator at -20 °C for 3 min to promote crystallization. After precipitating a large amount of solid, the product was collected by filtration and dried under high vacuum to give 150 mg of a pale yellow solid in 92% yield.
References
[1] Patent: CN103804358, 2016, B. Location in patent: Paragraph 0123
[2] Patent: WO2006/17443, 2006, A2. Location in patent: Page/Page column 155
[3] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 57
[4] Patent: WO2015/81891, 2015, A1. Location in patent: Page/Page column 138; 139
[5] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 287
6-NITRO-ISOINDOLIN-1-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-NITRO-ISOINDOLIN-1-ONE manufacturers
- Product
- 6-NITRO-ISOINDOLIN-1-ONE 110568-64-4
- Price
- US $6.60/KG
- Min. Order
- 500g
- Purity
- 98%
- Supply Ability
- 1kg, 50kg, 100kg
- Release date
- 2019-12-25