6-AMino-2,3-dihydroisoindol-1-one
- Product Name
- 6-AMino-2,3-dihydroisoindol-1-one
- CAS No.
- 675109-45-2
- Chemical Name
- 6-AMino-2,3-dihydroisoindol-1-one
- Synonyms
- 6-Amino-1-isoindolinone;6-aminoisoindolin-1-one;6-AMino-2,3-dihydroisoindol-1-one;6-amino-2,3-dihydro-1H-Isoindol-1-one;1H-Isoindol-1-one, 6-aMino-2,3-dihydro-;1H-Isoindol-1-one, 6-amino-2,3-dihydro- (9CI);4,4'-METHYLENEBIS(6-BROMO-N,N-DIMETHYLANILINE)
- CBNumber
- CB11087661
- Molecular Formula
- C8H8N2O
- Formula Weight
- 148.16
- MOL File
- 675109-45-2.mol
6-AMino-2,3-dihydroisoindol-1-one Property
- Melting point:
- 247 °C
- Boiling point:
- 499.9±45.0 °C(Predicted)
- Density
- 1.307±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 14.77±0.20(Predicted)
- Appearance
- Light yellow to green yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A611595
- Product name
- 6-Aminoisoindolin-1-one
- Packaging
- 100mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 113139
- Product name
- 6-Aminoisoindolin-1-one
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 113139
- Product name
- 6-Aminoisoindolin-1-one
- Packaging
- 5g
- Price
- $564
- Updated
- 2021/12/16
- Product number
- CHM0114086
- Product name
- 6-AMINO-2,3-DIHYDRO-1H-ISOINDOL-1-ONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $983.52
- Updated
- 2021/12/16
- Product number
- 0385AC
- Product name
- 6-Amino-2,3-dihydro-1H-isoindol-1-one
- Packaging
- 25g
- Price
- $1357
- Updated
- 2021/12/16
6-AMino-2,3-dihydroisoindol-1-one Chemical Properties,Usage,Production
Uses
6-AMino-2,3-dihydroisoindol-1-one is used in the synthesis of a novel potent glycoprotein IIb-IIIa (GP IIb-IIIa) receptor antagonist based on the isoindolone skeleton.
Synthesis
110568-64-4
675109-45-2
General procedure for the synthesis of 6-amino-isoindolin-1-one from 6-nitro-isoindolin-1-one: A suspension of intermediate 6B (1.6 g, 8.98 mmol) and Pd/C (0.18 g) in methanol (100 mL) was stirred for 4 hr under hydrogen (1 atm) atmosphere. After completion of the reaction, the reaction mixture was filtered and the filter cake was washed with methanol. After combining the filtrates, the solvent was removed by concentration under reduced pressure. The crude product was ground with methanol (10 mL) and subsequently dried under reduced pressure to afford intermediate 6 (800 mg, 5.40 mmol, 60.1% yield) as a beige solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 4.15 (s, 2H), 5.26 (s, 2H), 6.77 (dd, J = 8.25, 2.20 Hz, 1H), 6.80 (s, 1H), 7.16 (d, J = 8.79 Hz, 1H), 8.29 (s, 1H). The mass spectrum (ESI) showed m/z 149.2 ([M + H]+).
References
[1] Patent: WO2008/79759, 2008, A1. Location in patent: Page/Page column 91-92
[2] Patent: WO2008/79836, 2008, A2. Location in patent: Page/Page column 87
[3] Chemische Berichte, 1934, vol. 67, p. 675,681
[4] Patent: WO2010/10184, 2010, A1. Location in patent: Page/Page column 59
[5] Patent: US2004/58970, 2004, A1. Location in patent: Page 14
6-AMino-2,3-dihydroisoindol-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
6-AMino-2,3-dihydroisoindol-1-one Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- 022-66211289-843 13672102692
- Fax
- QQ：2377893365
- contact@sphinxpharm.com
- Country
- China
- ProdList
- 361
- Advantage
- 62
- Tel
- 027-88041443 13072715837
- Fax
- 027-51829379
- sales@hetero-chem.com
- Country
- China
- ProdList
- 696
- Advantage
- 58
- Tel
- 025-58395930
- Fax
- 025-5861-9182
- sales@acornpharma.com
- Country
- China
- ProdList
- 982
- Advantage
- 60
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 0755-83725681-603
- Fax
- +86 755 28094224
- Country
- China
- ProdList
- 4496
- Advantage
- 50
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 021-57171705 13817537615
- Fax
- QQ3095748324
- sales@run-biotech.com
- Country
- China
- ProdList
- 2337
- Advantage
- 58
View Lastest Price from 6-AMino-2,3-dihydroisoindol-1-one manufacturers
- Product
- 6-AMino-2,3-dihydroisoindol-1-one 675109-45-2
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2019-12-24