4-(4-Pyridinyl)thiazole-2-thiol
- Product Name
- 4-(4-Pyridinyl)thiazole-2-thiol
- CAS No.
- 77168-63-9
- Chemical Name
- 4-(4-Pyridinyl)thiazole-2-thiol
- Synonyms
- 4-(4-Pyridinyl)thiaz;3-Side chain of Ceftaroline;4-(4-pyridyl)thiazole-2-thiol;4-(Pyridinyl)thiazole-2-thiol;4-(4-Pyridinyl)thiazole-2-thio;4-(4-Pyridinyl)thiazole-2-thiol;4-(pyridin-4-yl)thiazole-2-thiol;2-Mercapto-4-(4-Pyridinyl)thiazole;4-(4-Pyridyl)thiazole-2(3H)-thione;4-(4-Pyridyl)-1,3-thiazole-2-thiol
- CBNumber
- CB61563591
- Molecular Formula
- C8H6N2S2
- Formula Weight
- 194.28
- MOL File
- 77168-63-9.mol
4-(4-Pyridinyl)thiazole-2-thiol Property
- Boiling point:
- 364.8±52.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.01±0.40(Predicted)
- Appearance
- Yellow to brown Solid
- InChI
- InChI=1S/C8H6N2S2/c11-8-10-7(5-12-8)6-1-3-9-4-2-6/h1-5H,(H,10,11)
- InChIKey
- LEQNUYXXLYRUNY-UHFFFAOYSA-N
- SMILES
- S1C=C(C2C=CN=CC=2)NC1=S
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P992155
- Product name
- 4-(4-Pyridinyl)thiazole-2-thiol
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- P992155
- Product name
- 4-(4-Pyridinyl)thiazole-2-thiol
- Packaging
- 25g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- P000142407
- Product name
- 4-(Pyridin-4-yl)thiazole-2-thiol
- Purity
- 97%
- Packaging
- 1g
- Price
- $8
- Updated
- 2021/12/16
- Product number
- P000142407
- Product name
- 4-(Pyridin-4-yl)thiazole-2-thiol
- Purity
- 97%
- Packaging
- 5g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- X4779
- Product name
- 4-(4-Pyridinyl)thiazole-2-thiol
- Packaging
- 100g
- Price
- $235
- Updated
- 2021/12/16
4-(4-Pyridinyl)thiazole-2-thiol Chemical Properties,Usage,Production
Chemical Properties
Pale yellow powder
Uses
4-(4-Pyridinyl)thiazole-2-thiol is a reactant used to synthesize novel thiazolidine derivatives and azetidinone derivatives, which possess antiproliferative activity and inhibitory activity against the proliferation of the MCF-7 breast cancer cell line.
Synthesis
6221-13-2
513-74-6
77168-63-9
The general procedure for the synthesis of 2-mercapto-4-(4-pyridinyl)thiazole from 2-bromo-1-(pyridin-4-yl)ethanone and ammonium dithiocarbamate was as follows: to 1000 ml of water, 60 g of 4-acetylpyridine was added, the temperature was maintained at 10-15 °C, followed by the slow addition of 101 g of hydrobromic acid. Gradually 87.9 g of bromine was added dropwise at the same temperature and the reaction was kept for 1 hour after the dropwise addition. The reaction system was then warmed up to 30-35 °C and the reaction was continued for 4 h. The progress of the reaction was monitored by HPLC until the feedstock was completely consumed. Upon completion of the reaction, the reaction solution was cooled to 0 °C, 66 g of ammonium dithiocarbamate was added and the reaction was kept at 0 °C for 1 hour. After that, the reaction system was slowly warmed up to 20-25°C and the reaction was continued for 4 hours. At the end of the reaction, the solid was collected by filtration to give 81.7 g of crude 2-mercapto-4-(pyridin-4-yl)thiazole. The crude product was refluxed in water for 2 h. After cooling and filtration, 80.2 g of purified 2-mercapto-4-(pyridin-4-yl)thiazole was obtained in 82.6% yield, and the product was a light yellow solid with 99.7% HPLC purity.
References
[1] Patent: CN104031040, 2016, B. Location in patent: Paragraph 0023; 0024
4-(4-Pyridinyl)thiazole-2-thiol Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4-Pyridinyl)thiazole-2-thiol Suppliers
- Tel
- 0531-88901705 18753193522
- 810353473@qq.com
- Country
- China
- ProdList
- 159
- Advantage
- 58
- Tel
- 15238060619
- liucunjiang_11@163.com
- Country
- China
- ProdList
- 43
- Advantage
- 58
- Tel
- 86-021-50318510
- Fax
- 021-58650104
- Country
- China
- ProdList
- 69
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 15527768836
- 1791901229@qq.com
- Country
- China
- ProdList
- 6950
- Advantage
- 52
- Tel
- 0531-0531-58897003 15550412551
- Fax
- 0531-58897003
- market@jnchsd.com
- Country
- China
- ProdList
- 229
- Advantage
- 62
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
View Lastest Price from 4-(4-Pyridinyl)thiazole-2-thiol manufacturers
- Product
- 4-(4-Pyridinyl)thiazole-2-thiol 77168-63-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2000
- Release date
- 2025-04-15
- Product
- 4-(4-Pyridinyl)thiazole-2-thiol 77168-63-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-19
- Product
- 4-(4-Pyridinyl)thiazole-2-thiol 77168-63-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 100kg
- Purity
- ≥99.0%
- Supply Ability
- 20 tons
- Release date
- 2024-07-30