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Carebastine-d5

Product Name
Carebastine-d5
CAS No.
1189661-02-6
Chemical Name
Carebastine-d5
Synonyms
Carebastine-d5;Valine Impurity 136;4-[4-[4-(DiphenylMethoxy-d5)-1-piperidinyl]-1-oxobutyl]-α,α-diMethylbenzeneacetic Acid;4-[4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-oxobutyl]-a,a-dimethylbenzeneacetic Acid;4-[4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-oxobutyl]-α,a-dimethylbenzeneacetic Acid
CBNumber
CB61565757
Molecular Formula
C32H37NO4
Formula Weight
499.64048
MOL File
1189661-02-6.mol
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Carebastine-d5 Property

Melting point:
72-74°C
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White to Light Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30755
Product name
Carebastine-d5
Packaging
1mg
Price
$275
Updated
2024/03/01
TRC
Product number
C183442
Product name
Carebastine-d5
Packaging
1mg
Price
$220
Updated
2021/12/16
Usbiological
Product number
005778
Product name
Carebastine-d5
Packaging
1mg
Price
$502
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0006701
Product name
CAREBASTINE-D5
Purity
95.00%
Packaging
1MG
Price
$785.4
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0006701
Product name
CAREBASTINE-D5
Purity
95.00%
Packaging
2.5MG
Price
$1180
Updated
2021/12/16
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Carebastine-d5 Chemical Properties,Usage,Production

Description

Carebastine-d5 is intended for use as an internal standard for the quantification of carebastine by GC- or LC-MS. Carebastine is an active metabolite of ebastine and a histamine H1 receptor antagonist (Ki = 75.86 nM). It inhibits histamine-induced contraction of isolated guinea pig trachea (IC50 = 120 nM). It also inhibits histamine release from isolated rat peritoneal mast cells and human basophils when used at concentrations ranging from 30 to 100 μM. Carebastine decreases production of chemokine (C-C motif) ligand 5 (CCL5) and CCL2 in human nasal epithelial cells isolated from patients with nasal allergies.

Chemical Properties

Off-White Solid

Uses

The active labelled carboxylic acid metabolite of Ebastine.

IC 50

H1 Receptor

References

[1] J. VINCENT. The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects.[J]. British journal of clinical pharmacology, 1988, 26 5: 497-502. DOI: 10.1111/j.1365-2125.1988.tb05288.x
[2] KWANG-HYEON LIU. Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.[J]. Drug Metabolism and Disposition, 2006, 34 11: 1793-1797. DOI: 10.1124/dmd.106.010488
[3] SHIGERU HISHINUMA . Asp73-dependent and -independent regulation of the affinity of ligands for human histamine H1 receptors by Na+[J]. Biochemical pharmacology, 2017, 128: Pages 46-54. DOI: 10.1016/j.bcp.2016.12.021
[4] I YAKUO. [Pharmacological study of ebastine, a novel histamine H1-receptor antagonist].[J]. Folia Pharmacologica Japonica, 1994, 103 3: 121-135. DOI: 10.1254/fpj.103.121
[5] YOKO YAMAUCHI  Tatsuo S  Terumichi Fujikura. The Effect of H1 Antagonists Carebastine and Olopatadine on Histamine Induced Expression of CC Chemokines in Cultured Human Nasal Epithelial Cells[J]. Allergology International, 2007, 56 2: Pages 171-177. DOI: 10.2332/allergolint.o-06-446

Carebastine-d5 Preparation Products And Raw materials

Raw materials

Preparation Products

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Carebastine-d5 Suppliers

Canada 1 China 22 India 3 United States 3 Global 29
Chemsky（shanghai）International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
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China
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Cato Research Chemicals Inc.
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+1-541-2553641
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min.he@cato-chem.com
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China
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Energy Chemical
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021-58432009 400-005-6266
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Nanjing Shizhou Biology Technology Co.,Ltd
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BePure (Beijing) Biotechnology Co.
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Cayman Chemical Company
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Santa Cruz Biotechnology Inc
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1189661-02-6, Carebastine-d5Related Search:


  • 4-[4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-oxobutyl]-α,a-dimethylbenzeneacetic Acid
  • Carebastine-d5
  • 4-[4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-oxobutyl]-a,a-dimethylbenzeneacetic Acid
  • 4-[4-[4-(DiphenylMethoxy-d5)-1-piperidinyl]-1-oxobutyl]-α,α-diMethylbenzeneacetic Acid
  • Valine Impurity 136
  • 1189661-02-6
  • C32H32D5NO4
  • Intermediates & Fine Chemicals
  • Isotope Labeled Compounds
  • Metabolites & Impurities
  • Pharmaceuticals
  • Isotope Labelled Compounds