Carebastine-d5

Product Name: Carebastine-d5
CAS No.: 1189661-02-6
Chemical Name: Carebastine-d5
Synonyms: Carebastine-d5;Valine Impurity 136;4-[4-[4-(DiphenylMethoxy-d5)-1-piperidinyl]-1-oxobutyl]-α,α-diMethylbenzeneacetic Acid;4-[4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-oxobutyl]-a,a-dimethylbenzeneacetic Acid;4-[4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-oxobutyl]-α,a-dimethylbenzeneacetic Acid
CBNumber: CB61565757
Molecular Formula: C32H37NO4
Formula Weight: 499.64048
MOL File: 1189661-02-6.mol

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Carebastine-d5 Property

Melting point:: 72-74°C
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Solid
color: Off-White to Light Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30755
Product name: Carebastine-d5
Packaging: 1mg
Price: $275
Updated: 2024/03/01

TRC

Product number: C183442
Product name: Carebastine-d5
Packaging: 1mg
Price: $220
Updated: 2021/12/16

Usbiological

Product number: 005778
Product name: Carebastine-d5
Packaging: 1mg
Price: $502
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0006701
Product name: CAREBASTINE-D5
Purity: 95.00%
Packaging: 1MG
Price: $785.4
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0006701
Product name: CAREBASTINE-D5
Purity: 95.00%
Packaging: 2.5MG
Price: $1180
Updated: 2021/12/16

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Carebastine-d5 Chemical Properties,Usage,Production

Description

Carebastine-d₅ is intended for use as an internal standard for the quantification of carebastine by GC- or LC-MS. Carebastine is an active metabolite of ebastine and a histamine H₁ receptor antagonist (K_i = 75.86 nM). It inhibits histamine-induced contraction of isolated guinea pig trachea (IC₅₀ = 120 nM). It also inhibits histamine release from isolated rat peritoneal mast cells and human basophils when used at concentrations ranging from 30 to 100 μM. Carebastine decreases production of chemokine (C-C motif) ligand 5 (CCL5) and CCL2 in human nasal epithelial cells isolated from patients with nasal allergies.

Chemical Properties

Off-White Solid

Uses

The active labelled carboxylic acid metabolite of Ebastine.

IC 50

H₁ Receptor

References

[1] J. VINCENT. The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects.[J]. British journal of clinical pharmacology, 1988, 26 5: 497-502. DOI: 10.1111/j.1365-2125.1988.tb05288.x
[2] KWANG-HYEON LIU. Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.[J]. Drug Metabolism and Disposition, 2006, 34 11: 1793-1797. DOI: 10.1124/dmd.106.010488
[3] SHIGERU HISHINUMA . Asp73-dependent and -independent regulation of the affinity of ligands for human histamine H1 receptors by Na+[J]. Biochemical pharmacology, 2017, 128: Pages 46-54. DOI: 10.1016/j.bcp.2016.12.021
[4] I YAKUO. [Pharmacological study of ebastine, a novel histamine H1-receptor antagonist].[J]. Folia Pharmacologica Japonica, 1994, 103 3: 121-135. DOI: 10.1254/fpj.103.121
[5] YOKO YAMAUCHI Tatsuo S Terumichi Fujikura. The Effect of H1 Antagonists Carebastine and Olopatadine on Histamine Induced Expression of CC Chemokines in Cultured Human Nasal Epithelial Cells[J]. Allergology International, 2007, 56 2: Pages 171-177. DOI: 10.2332/allergolint.o-06-446

Carebastine-d5 Preparation Products And Raw materials

Raw materials

Preparation Products

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Carebastine-d5 Suppliers

Canada 1 China 22 India 3 United States 3 Global 29

Chemsky（shanghai）International Co.,Ltd.

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Energy Chemical

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ChemeGen

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Shanghai Yiyan Biotechnology Co. , Ltd.

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Shanghai isotope chemical co.,ltd

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Shanghai Yifei Biotechnology Co. , Ltd.

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Nanjing Shizhou Biology Technology Co.,Ltd

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1189661-02-6, Carebastine-d5Related Search:

4-[4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-oxobutyl]-α,a-dimethylbenzeneacetic Acid

Carebastine-d5

4-[4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-oxobutyl]-a,a-dimethylbenzeneacetic Acid

4-[4-[4-(DiphenylMethoxy-d5)-1-piperidinyl]-1-oxobutyl]-α,α-diMethylbenzeneacetic Acid

Valine Impurity 136

1189661-02-6

C32H32D5NO4

Intermediates & Fine Chemicals

Isotope Labeled Compounds

Metabolites & Impurities

Pharmaceuticals

Isotope Labelled Compounds