2'-Deoxy-5'-O-DMT-2'-fluorouridine

Product Name: 2'-Deoxy-5'-O-DMT-2'-fluorouridine
CAS No.: 146954-74-7
Chemical Name: 2'-Deoxy-5'-O-DMT-2'-fluorouridine
Synonyms: 2'-F-dU;DMT-2'-F-U;DMT-2'-F-dU;5-DMT-2'-F-dT;5'-DMT-2'-F-dU;1-((2R,3R,4R,5R);5'-O-DMT-2'-F-dU;5'-O-DMTr-2'-F-dU;2'-F-5'-O-DMT-2'-dU;-5-((Bis(4-methoxyphenyl)
CBNumber: CB6156598
Molecular Formula: C30H29FN2O7
Formula Weight: 548.56
MOL File: 146954-74-7.mol

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2'-Deoxy-5'-O-DMT-2'-fluorouridine Property

Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 9.39±0.10(Predicted)
form: Powder
color: White to Pale Yellow
InChIKey: CSSFZSSZXOCCJB-MNBKXICWNA-N
SMILES: N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2=CC=C(C=C2)OC)C2=CC=C(C=C2)OC)[C@@H](O)[C@H]1F |&1:8,10,36,38,r|

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M226545
Product name: 1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Packaging: 25mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M226545
Product name: 1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Packaging: 50mg
Price: $60
Updated: 2021/12/16

TRC

Product number: M226545
Product name: 1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND06064
Product name: 2'-Deoxy-5'-O-DMT-2'-fluorouridine
Packaging: 2g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND06064
Product name: 2'-Deoxy-5'-O-DMT-2'-fluorouridine
Packaging: 5G
Price: $112
Updated: 2021/12/16

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2'-Deoxy-5'-O-DMT-2'-fluorouridine Chemical Properties,Usage,Production

Uses

2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity[1].

Definition

2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity.

Biological Activity

2'-Deoxy-5'-O-DMT-2'-fluorouridine (compound 15h) has 100% inhibition against YFV at 20 mM. 2'-Deoxy-5'-O-DMT-2'-fluorouridine proves to be noncytotoxic at concentrations up to 20 mM.

Synthesis

40615-36-9

56287-17-3

146954-74-7

2'-Deoxy-2'-fluorouridine (3.00 g, 12.2 mmol) was dissolved in anhydrous pyridine, and the decompression concentration operation was repeated three times to achieve dehydration azeotropic distillation. Subsequently, the reaction mixture was dissolved in anhydrous pyridine (120 mL) under argon protection, 4,4'-dimethoxytrityl chloride (4.55 g, 13.4 mmol) was added, and the reaction was stirred for 3 hours at room temperature. After completion of the reaction, ethyl acetate (150 mL) and water (60 mL) were added to the reaction mixture and layered. The organic layer was washed sequentially with 5% aqueous sodium bicarbonate (20 mL x 3), water (20 mL) and saturated saline (20 mL), followed by drying with anhydrous sodium sulfate. After filtration, the solvent was removed by evaporation and the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 50:50 to 0:100 (v/v) containing 1% triethylamine). The fraction containing the target product was collected and concentrated to give 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (8.48 g, quantitative yield).

References

[1] Christopher McGuigan, et al. Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues. ChemistryOpen. 2016 Jan 21;5(3):227-35. DOI:10.1002/open.201500216

2'-Deoxy-5'-O-DMT-2'-fluorouridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Deoxy-5'-O-DMT-2'-fluorouridine Suppliers

China 122 France 1 Germany 1 India 6 The Netherlands 1 United Kingdom 3 United States 12 Global 146

Hongene Biotech Corporation

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China DongFan Chemical Co.,LTD

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Hunan Hui Bai Shi Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Bide Pharmatech Ltd.

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Finetech Industry Limited

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NINGBO INNO PHARMCHEM CO.,LTD.

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View Lastest Price from 2'-Deoxy-5'-O-DMT-2'-fluorouridine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: 2'-Deoxy-5'-O-DMT-2'-fluorouridine 146954-74-7
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: 2000
Release date: 2025-06-04

Henan Aochuang Chemical Co.,Ltd.

Product: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE 146954-74-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-23

Hefei Huana Biomedical Technology Co.,Ltd.

Product: DMT-2'-F-dU 146954-74-7
Price: US $0.00/g
Min. Order: 100g
Purity: ≥98%(HPLC)
Supply Ability: 20t
Release date: 2023-03-29

146954-74-7, 2'-Deoxy-5'-O-DMT-2'-fluorouridineRelated Search:

N-Acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]cytidine 5'-O-DMT-2'-TBDMS-Uridine 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-O-METHYLURIDINE 2'-O-TBDMS-5'-O-DMT-N4-Ac cytidin 5'-O-(4,4'-Dimethoxytrityl)uridine 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE 2'-Fluoro-2'-deoxyuridine 2'-Fluoro-5'-O-dimethoxytrityluridine-3'-O-cyanoethyldiisopropropylphosphoramidite

5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE

2'-Deoxy-5'-O-DMT-2'-fluoro-D-uridine

2'-Deoxy-5'-O-DMT-2'-fluorouridine

5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine

5'-O-(4,4'-DiMethoxytrityl)-2'-fluoro-2'-deoxyuridine

1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione

1-((2R,3R,4R,5R)

-3-fluoro-4-hydroxytetrahydrofuran-2-yl)

-5-((Bis(4-methoxyphenyl)

2'-Deoxy-5'-O-DMTr-2'-fluoro-uridine

DMT-2'-F-dU

1-(5-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-3-FLUORO-4-HYDROXYOXOLAN-2-YL)-3H-PYRIMIDINE-2,4-

5'-DMT-2'-F-dU

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-

5'-O-DMT-2'-F-dU

2’-Deoxy-5’-O-(4,4’-dimethoxytrityl)-2’-fluorouridine

5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE USP/EP/BP

1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine, 98%,

DMT-2'-F-U

5-DMT-2'-F-dT

5'-ODMT-2'-Fluoro Uridine

2'-F-dU

1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-3-fluoro-4-hydroxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione

5'-O-DMT-2'-fluoro-2'-deoxyuridine

5'-O-DMT-2'-F-deoxyuridine

5’-O-(4,4’-Dimethoxytrityl)-2’-fluoro-2’-deoxyuridine

2'-F-5'-O-DMT-2'-dU

5'-O-DMTr-2'-F-dU

5 ' - 0 - (4,4'- DIMETHOXYTRI - TYL) - 2'- FLUORO- D- URDINE

5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-Fluoro-2'-Deoxyuridine

5'-O-DMT-2'-Fluoro-2'-deoxyuridine

5'-O-DMT-2'-F-dU, 5'-O-(4,4’-dimethoxytrityl)-2’-fluoro-2’-deoxyuridine

146954-74-7

C30H29N2O7F

Modified（deoxy）nucleoside