2'-Fluoro-2'-deoxyuridine

Product Name: 2'-Fluoro-2'-deoxyuridine
CAS No.: 784-71-4
Chemical Name: 2'-Fluoro-2'-deoxyuridine
Synonyms: 2-FdU;2'-FU;2'-FUDR;2'-F-2'-dU;Fioluridine;2'-FLUORO-D-URIDINE;2'-Fluoro-2'-deoxyur;2'-F-2'-deoxyuridine;2 '- Fluorodeoxyuridine;2'-Deoxy-2'-fluorouridine
CBNumber: CB3358175
Molecular Formula: C9H11FN2O5
Formula Weight: 246.19
MOL File: 784-71-4.mol

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2'-Fluoro-2'-deoxyuridine Property

Melting point:: 147.0 to 153.0 °C
Density: 1.63±0.1 g/cm3(Predicted)
refractive index: 53 ° (C=0.3, H2O)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in methanol.
form: Powder
pka: 9.39±0.10(Predicted)
color: White to Off-white
optical activity: α20/D +53°±3°, c = 0.3 in water
Water Solubility: soluble in water
InChI: InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1
InChIKey: UIYWFOZZIZEEKJ-XVFCMESISA-N
SMILES: OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O
CAS DataBase Reference: 784-71-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-40
Safety Statements: 22-36/37/39
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3615
Product name: 2'-Deoxy-2'-fluorouridine
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $28
Updated: 2025/07/31

TCI Chemical

Product number: D3615
Product name: 2'-Deoxy-2'-fluorouridine
Purity: >97.0%(HPLC)
Packaging: 5g
Price: $109
Updated: 2025/07/31

TRC

Product number: F590275
Product name: 2''-Fluoro-2''-deoxyuridine
Packaging: 100mg
Price: $155
Updated: 2021/12/16

Ark Pharm

Product number: P000722636
Product name: 2'-Deoxy-2'-fluorouridine
Purity: 98%
Packaging: 250mg
Price: $9
Updated: 2021/12/16

Ark Pharm

Product number: P000722636
Product name: 2'-Deoxy-2'-fluorouridine
Purity: 98%
Packaging: 1g
Price: $22
Updated: 2021/12/16

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2'-Fluoro-2'-deoxyuridine Chemical Properties,Usage,Production

Description

2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity.

Chemical Properties

White to almost white crystalline powder

Uses

2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.

Uses

A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.

Synthesis

Method for the synthesis of 2'-Fluoro-2'-deoxyuridine, comprising the following steps:
(1) Uridine, diphenyl carbonate was added in dimethylformamide, dissolved at elevated temperature, the solution was clarified, the catalyst sodium bicarbonate was added under the condition of maintaining temperature, the reaction was carried out at elevated temperature for the second time, the reaction was completed, the temperature was cooled down naturally to room temperature, stirred, filtered, and the cake was dried to obtain compound 2.
(2) Compound 2, anhydrous potassium fluoride, catalyst boron trifluoride ethyl ether dissolved in a solvent, temperature rise reaction, after the completion of the reaction, filtration and concentration, to obtain 2'-fluoro-2'-deoxyuridine.
However, the hydroxyl conversion rate of this method is low, 2'-fluoro-2'-deoxyuridine is an extremely viscous compound, and it cannot be cured and purified when the purity is not high, resulting in the need for the method to be purified by passing through a column at a later stage, and it cannot be used in a factory for continuous and scaled-up production.

References

[1] Nucleosides, Nucleotides and Nucleic Acids, 2018, vol. 37, # 4, p. 232 - 247

2'-Fluoro-2'-deoxyuridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-Fluoro-2'-deoxyuridine Suppliers

Americas 1 Austria 1 Canada 2 China 340 Europe 3 France 1 Germany 5 India 7 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 16 United States 46 Global 426

Zhengzhou First biochem technology Co.,Ltd.

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Hongene Biotech Corporation

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Zhejiang Huida Biotech Co., LTD

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Jiangsu Synthgene Biotechnology Co.,Ltd.

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Innobio Pharm Co.,Ltd

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Nanjing Shenhui Biotechnology Co., Ltd

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Tianjin Orilife Biopharma Co.,Ltd.

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Suzhou Nordica Biopharma Co.,LTD

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Shanghai Peiling Biological Technology Co., Ltd

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J & K SCIENTIFIC LTD.

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View Lastest Price from 2'-Fluoro-2'-deoxyuridine manufacturers

Xinxiang Aurora Biotechnology Co.,Ltd.

Product: 2'-Deoxy-2'-fluorouridine 784-71-4
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20Ton
Release date: 2024-11-01

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2'-Fluoro-2'-deoxyuridine 784-71-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2'-Fluoro-2'-deoxyuridine 784-71-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

784-71-4, 2'-Fluoro-2'-deoxyuridineRelated Search:

Trifluridine 2'-Deoxyuridine Doxifluridine 2'-DEOXY-2'-FLUOROTHYMIDINE 5-Fluoro-2'-deoxyuridine 98%,(+)-5-FLUORO-2'-DEOXYURIDINE,5-FLUORO-2'-DEOXYURIDINE,5-FLUORO-2-DEOXYURIDINE,beta-5-fluoro-2’-deoxyuridin uridine diphosphate glucose {= UDP-glucose} BrdU (Bromodeoxyuridine) Fluorine DMT-2′Fluoro-dU Phosphoramidite Uridine 2',2'-DIFLUORO-2'-DEOXYURIDINE 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE 2'-FLUORODEOXYURIDINE-5,6-D2 2'-FLUORO-2'DEOXYURIDINE, [5'-3H] 2',2'-DIFLUORO-2'-DEOXYURIDINE 13C, 15N2 3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE 5-FLUORO 2'-DEOXYURIDINE, [6-3H]-,5'-FLUORO-2'DEOXYURIDINE, [6-3H] 3',5'-DI-O-ACETYL-5-FLUORO-2'-DEOXYURIDINE

1-(2'-FLUORO-2'-DESOXY-BETA-D-RIBOFURANOSYL)URACIL

2,4(1H,3H)-PYRIMIDINEDIONE, 1-(2-DEOXY-2-FLUORO-BETA-D-RIBOFURANOSYL)

2'-FLUORO-2'-DESOXY-URIDINE

2'-FLUORO-D-URIDINE

2'-FUDR

2'-FU

2'-DEOXY-2'-FLUOROURIDINE (2'-FLUORO-2'- DEOXYURIDINE, 2'-FU)

2'-Deoxy-2'-fluoro-D-uridine

2''-DEOXY-2''-FLUOROURIDINE (2''-FLUORO-2''- DEOXYURIDINE)

URIDINE,2''-DEOXY-2''-FLUORO

2-FdU

2'-Fluoro-5'-O-DMT-2'-deoxyuridine

1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone

2'-Fluoro-2'-deoxyur

Fioluridine

FN-011 2'-Fluoro-2'-deoxyuridine

2'-Deoxy-2'-fluorouridine≥ 97% (HPLC)

2'-Fluoro-2'-deoxyuridine 98%

2'-Deoxy-2'-fluorouridine, 98.0%

Uridine Impurity 19 （2'-Fluoro-2'-deoxyuridine）

2'-Deoxy-2'-fluorouridine&gt

2'-F-2'-dU

2'-Fluoro-2'-deoxyuridine USP/EP/BP

2'-F-2'-deoxyuridine

inhibit,2' Deoxy 2' fluorouridine,Inhibitor,antiinfluenza virus,influenza,Influenza Virus,intermediate,2'Deoxy2'fluorouridine

2 '- Fluorodeoxyuridine

1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

2'-Fluoro-2'-Deoxyuridine (FdU)

2'-Deoxy-2'-fluorouridine

2'-Fluoro-2'-deoxyuridine

2''-Deoxy-2''-fluorouridine

2''-Deoxy-2''-fluorouridine, 10 mM in DMSO

2′-deoxy-2′-Fluorouridine, CAS 784-71-4

2'-Fluoro-2'-deoxyuridine

2′-Deoxy-2′-fluorouridine

784-71-4

781-71-4

Bases & Related Reagents

Intermediates & Fine Chemicals

Nucleotides

Pharmaceuticals

API intermediates

Biochemistry

Nucleosides and their analogs

Nucleosides, Nucleotides & Related Reagents

Pyridines, Pyrimidines, Purines and Pteredines

784-71-4

Nucleosides

Modified（deoxy）nucleoside

Nucleosides-2'-F Nucleosides

1