DMT-2′Fluoro-dU Phosphoramidite

Product Name: DMT-2′Fluoro-dU Phosphoramidite
CAS No.: 146954-75-8
Chemical Name: DMT-2′Fluoro-dU Phosphoramidite
Synonyms: 2‘-F-U amidite;2'-Fluoro-dU CEP;2’-F-dU Amidite;2’-F-rUPhosphoramidite;2'-F-U Phosphoramidite;2'-F-dU Phosphoramidite;5'-O-DMT-2'-fluoro-dU-CE;5'-O-DMT-2'-F-dU-3'-CEDPA;2'-Fluoro Uridine Amidite;2'-Fluoro Uridine Amidite
CBNumber: CB8500324
Molecular Formula: C39H46FN4O8P
Formula Weight: 748.78
MOL File: 146954-75-8.mol

More

Less

DMT-2′Fluoro-dU Phosphoramidite Property

storage temp.: Sealed in dry,Store in freezer, under -20°C
form: powder
pka: 9.39±0.10(Predicted)
color: white to off-white
InChI: InChI=1/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-24-10-22-41)52-36-33(51-37(35(36)40)43-23-21-34(45)42-38(43)46)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,42,45,46)/t33-,35-,36-,37-,53?/s3
InChIKey: HQHQPAYRJJMYQX-YOKGOYKLNA-N
SMILES: N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2C=CC(=CC=2)OC)C2=CC=C(C=C2)OC)[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@H]1F |&1:8,10,36,51,r|

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: U211280
Product name: DMT-2′Fluoro-dU Phosphoramidite
Purity: configured for PerkinElmer, configured for Polygen
Packaging: 1G
Price: $206
Updated: 2024/03/01

Sigma-Aldrich

Product number: U211250
Product name: DMT-2′Fluoro-dU Phosphoramidite
Purity: configured for (?KTA? and OligoPilot?)
Packaging: 1G
Price: $219
Updated: 2024/03/01

Sigma-Aldrich

Product number: U211200
Product name: DMT-2′Fluoro-dU Phosphoramidite
Purity: ≥99% (31P-NMR)
Packaging: 100g
Price: $8200
Updated: 2024/03/01

Sigma-Aldrich

Product number: U211200
Product name: DMT-2′Fluoro-dU Phosphoramidite
Purity: ≥99% (31P-NMR)
Packaging: 500g
Price: $36650
Updated: 2024/03/01

Sigma-Aldrich

Product number: U211280
Product name: DMT-2′Fluoro-dU Phosphoramidite
Purity: configured for PerkinElmer, configured for Polygen
Packaging: 2g
Price: $383
Updated: 2024/03/01

More

Less

DMT-2′Fluoro-dU Phosphoramidite Chemical Properties,Usage,Production

Uses

5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite (DMT-2′Fluoro-dU Phosphoramidite) is a uridine phosphoramidite consisting of a fluorine in the 2' position, and the compound is used in the synthesis of DNA.

Definition

DMT-2′Fluoro-dU Phosphoramidite is also known as 2'-F-U CE-Phosphoramidite. 2'-F-RNA oligonucleotides adopt an A-form helix on hybridisation to a target. Whereas a hydroxyl group of RNA is a hydrogen bond donor, fluorine appears to be a weak acceptor. These features of 2'-F-RNA oligonucleotides lead to certain interesting properties. For example, it was demonstrated that oligonucleotides hybridise to a RNA oligonucleotide in the following order of increasing stability: DNA < RNA < 2'-OMe-RNA < 2'-F-RNA

Synthesis

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine (3.00 g, 5.47 mmol) was dissolved in anhydrous dichloromethane (50 ml) under an argon atmosphere, N,N-diisopropylethylamine (0.55 ml,3.18 mmol), 1H-tetrazole (0.45 g, 6.45 mmol) and 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite (1.92 g, 6.36mmol) were added. And the mixture was stirred at room temperature overnight. The completion of the reaction was confirmed, 5 percent aqueous sodium hydrogen carbonate solution (20 ml) was added to the reaction mixture to allow layer separation, and the organic layer was washed with saturated brine (20 ml). The organic layer was dried over sodium sulfate, the filtrate was concentrated and the obtained crude product was purified by silica gel chromatography (hexane:ethyl acetate=75:25 - 30/70(v/v), containing 3percent triethylamine). The object fractions were collected and concentratedto give DMT-2′Fluoro-dU Phosphoramidite (2.76 g, 67.3 percent).

DMT-2′Fluoro-dU Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

DMT-2′Fluoro-dU Phosphoramidite Suppliers

Canada 1 China 147 India 5 Switzerland 1 United Kingdom 2 United States 12 Global 168

Wuhu Nuowei Chemical Technology Co., Ltd

Tel: 0553-8233716 18055326116
Email: kendoll@cqpharm.com
Country: China
ProdList: 645
Advantage: 58

Hefei Huana Biomedical Technology Co.,Ltd

Tel: 17333066501
Email: shengwen.fang@huanaok.com.cn
Country: China
ProdList: 95
Advantage: 58

Hefei Stongbio Co.,Ltd.

Tel: 15555170917
Email: sales@stongbio.com
Country: China
ProdList: 480
Advantage: 58

Wuhu Huaren Science and Technology Co., Ltd.

Tel: 0553-0553-0553-5842013-801-801 18155347026
Fax: 086-553-5843138
Email: jinhuaren@huarensh.com
Country: China
ProdList: 295
Advantage: 64

Chemyouth Life Science（Suzhou）Co.,Ltd

Tel: 0512-52112288 13752065514
Email: jianwei@chemyouth.com
Country: China
ProdList: 49
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9461
Advantage: 58

More

Less

View Lastest Price from DMT-2′Fluoro-dU Phosphoramidite manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.

Product: 5'-O-DMT-2'-fluoro-dU-CE 146954-75-8
Price: US $0.00/mg
Min. Order: 100mg
Purity: ≥99%
Supply Ability: 20tons
Release date: 2023-03-09

R&D Scientific Inc.

Product: 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit 146954-75-8
Price: US $1550.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-02-10

SHANGHAI NOVRIBO BIOTECH

Product: 2'-F-dU CE Phosphoramidite 146954-75-8
Price: US $100.00/kg
Min. Order: 0.009999999776482582kg
Purity: 99%
Supply Ability: 5tons
Release date: 2023-03-21

146954-75-8, DMT-2′Fluoro-dU PhosphoramiditeRelated Search:

3-Chloropropyltrimethoxysilane Doxifluridine 1-beta-D-Arabinofuranosyluracil Pseudouridine 3-Chloropropyltriethoxysilane 3-Aminopropyltriethoxysilane Floxuridine 5-Fluorouridine DMT-dG(ib) Phosphoramidite DMT-dA(bz) Phosphoramidite DMT-2'O-Methyl-rU Phosphoramidite DMT-2'O-TBDMS-rA(bz) Phosphoramidite DMT-dG(dmf) Phosphoramidite 3'-TBDMS-ibu-rG Phosphoramidite Ac-rC Phosphoramidite Uridine DMT-2′Fluoro-dU Phosphoramidite

3-({[(2-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-5-(2,4-DIOXO-3H-PYRIMIDIN-1-YL)-4-FLUOROOXOLAN

2'-Fluoro-5'-O-DMT-2'-deoxyuridine-3'-CE-Phosphoramidite

5'-DMT-2'-F-rU Phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite

2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine Phosphoramidite

DMT-2'-F-DU AMIDITE 0.25G, AB, SINGLE

DMT-2'-F-dU Amidite 0.25g, 89, Single

2’-F-rUPhosphoramidite

5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

5'-O-DMT-2'-F-dU-3'-CEDPA

2'-F-dU Phosphoramidite

2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine-3'-CED PhosphoraMidite

DMT-2′Fluoro-dU Phosphoramidite

5'-O-DMT-2'-Fluoro-2'-deoxyuridine 3'-CE phosphoramidite

2'-Fluoro-dU CEP

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

5'-Dimethoxytrityl-deoxyUridine, 2'-fluoro-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

2'-Fluoro-N2-Isobutyryl-5'-O-DMT-2'-Deoxyguanosine-3'-CE-Phosphoramidite

5'-DMTr-2'-F-3'-O-CEP-URIDINE

5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite

5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit

2‘-F-U amidite

DMT-2'-F-U Phosphoramidite

DMT-2’-F-dU-CE Phosphoramidite

5'-O-DMT-2'-fluoro-dU-CE

Inhibitor,Nucleoside Antimetabolite/Analog,DMT2′FluorodU Phosphoramidite,inhibit,DMT 2′Fluoro dU Phosphoramidite

5'-O-DMT-2'-F-2'-Deoxy Uridine -3’-Cyanoethyl Phosphoramidite

2'-Fluoro Uridine Amidite

3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-tetrahydrofuran-3-yl]oxy-(diisopropylamino)phosphanyl]oxypropanenitrile

DMTr-2'-F-dU-3'-CE-Phosphoramidite

2’-F-dU Amidite

5'-O-(4, 4'-dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-CE-Phosphoramidite

5'-ODMT-2'-Fluoro uridine-3'-OCEPA

2'-F-U Phosphoramidite

DMT-2'-F-dU-CE Phosphoramidite

5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit

2'-Fluoro-2'-deoxy Uridine CED Phosphoramidite

2'-F-5'-O-DMT-2'-dU-3'-CE-Phosphoramidite

DMTr-2'-F-dU-3'-CE-Phosphoramidite

5'-O-DMT-2'-fluoro-2'-Deoxyuridine 3'-CE phosphoramidite

5'-O-DMT-2'-F-2'-Deoxy Uridine -3’-Cyanoethyl Phosphoramidite

2'-Fluoro Uridine Amidite

DMT-2'FLUORO-DU PHOSPHORAMIDITE

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

146954-75-8

Amidite