DMT-2'O-TBDMS-rA(bz) Phosphoramidite

Product Name: DMT-2'O-TBDMS-rA(bz) Phosphoramidite
CAS No.: 104992-55-4
Chemical Name: DMT-2'O-TBDMS-rA(bz) Phosphoramidite
Synonyms: Bz-rA Phosphoramidite;2'-TBDMS-A CEP;N-Benzoyl-5-O-(4;RNA N-Bz A Amidite;8-Aza-7-deaza-A CEP;DMT-2'-0-TBDMS-rA(BZ);DMT-2'-O-TBDMS-A(Bz)-CE;2’-OTBDMS-rA(Bz) Amidite;N-diisopropyl)phosphoramidite;2TBDMS-rA(BZ) Phosphoramidite
CBNumber: CB41871629
Molecular Formula: C53H66N7O8PSi
Formula Weight: 988.19
MOL File: 104992-55-4.mol

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DMT-2'O-TBDMS-rA(bz) Phosphoramidite Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: powder
pka: 7.87±0.43(Predicted)
color: white to off-white
InChI: InChI=1/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/s3
InChIKey: FFXHNCNNHASXCT-RFMFGJHUSA-N
SMILES: O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](O[Si](C(C)(C)C)(C)C)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,46,55,r|

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Safety

WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A211050
Product name: DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity: configured for (?KTA? and OligoPilot?)
Packaging: 2g
Price: $188
Updated: 2024/03/01

Sigma-Aldrich

Product number: A211050
Product name: DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity: configured for (?KTA? and OligoPilot?)
Packaging: 10g
Price: $916
Updated: 2024/03/01

Sigma-Aldrich

Product number: A211040
Product name: DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity: configured for MerMade
Packaging: 5G
Price: $372
Updated: 2024/03/01

Sigma-Aldrich

Product number: A211040
Product name: DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity: configured for MerMade
Packaging: 10g
Price: $941
Updated: 2024/03/01

Sigma-Aldrich

Product number: A211000
Product name: DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Packaging: 100g
Price: $7590
Updated: 2024/03/01

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DMT-2'O-TBDMS-rA(bz) Phosphoramidite Chemical Properties,Usage,Production

Uses

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.

Uses

DMT-2''O-TBDMS-rA(bz) Phosphoramidite (DMT-2'O-TBDMS-rA(bz) Phosphoramidite) is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.

Synthesis

To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 mL) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 ℃. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give DMT-2'O-TBDMS-rA(bz) Phosphoramidite as a white solid (13.0 g. 86% yield)

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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DMT-2'O-TBDMS-rA(bz) Phosphoramidite Suppliers

Canada 1 China 168 India 3 United Kingdom 2 United States 12 USA 1 Global 187

Hongene Biotech Corporation

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Wuhu Huaren Science and Technology Co., Ltd.

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Hefei Huana Biomedical Technology Co.,Ltd

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Accela ChemBio Co.,Ltd.

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View Lastest Price from DMT-2'O-TBDMS-rA(bz) Phosphoramidite manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.

Product: N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE 104992-55-4
Price: US $0.00/mg
Min. Order: 100mg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2023-03-09

Shaanxi Dideu Medichem Co. Ltd

Product: N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 104992-55-4
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-24

SHANGHAI NOVRIBO BIOTECH

Product: 2'-O-TBDMS-A(Bz) CE Phosphoramidite;Bz-rA 104992-55-4
Price: US $100.00/kg
Min. Order: 0.009999999776482582kg
Purity: 99%
Supply Ability: 5tons
Release date: 2023-03-21

104992-55-4, DMT-2'O-TBDMS-rA(bz) PhosphoramiditeRelated Search:

BENZOYL ISOCYANATE Buprofezin ADENOSINE 5'-TRIPHOSPHATASE tert-Butanol Benzoyl chloride Cyhalofop-butyl Benzoyl peroxide Dimethyldimethoxysilane tert-Butyl acetate tert-Butyldimethylsilyl chloride tert-Butyl peroxyacetate N-Benzoylaminopurine 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE TERT-BUTYLDIMETHYLSILANOL N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine N6-BENZYLADENOSINE N6-BENZOYL-3'-DEOXYADENOSINE DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE

DMT-2′O-TBDMS-rA(bz) Phosphoramidite

2'-TBDMS -Bz-rA-CE-Phosphoramidite

5'-DMT-2'-O-TBDMS- N6-Benzoyl-Adenosine Phosphoramidite

(2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite

REF DUPL: 2'-TBDMS-rA(N-Bz)Phosphoramidite

Bz-rA Phosphoramidite

N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 3'-CE phosphoramidite

5'-O-(4,4'-DiMethoxy)-N6-benzoyl-2'-O-(t-butyl diMethylsilyl)adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite

5'-O-DMT-2'-O-TDMS-N6-Bz-Adenosine-3'-CED PhosphoraMidite

Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-[(1,1-diMethylethyl)diMethylsilyl]-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite]

2’-TBDMS-rA(N-Bz) Phosphoramidite

5'-O-DMT-2'-TBDMS-rA(N-Bz)-3'-CEDPA

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide

5'-DMT-2'-TBDMS-rA(N-Bz) Phosphoramidite

5'-O-DMT-2'-O-tert-Butyldimethylsiyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite

8-Aza-7-deaza-A CEP

Adenosine,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-,3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)

5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite

5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine 3'-CE phosphoramidite

2'-TBDMS-A CEP

5'-DMT-2'-TBDMS-N6-Bz-rA phosphoramidite

4-Dimethoxytrityl)-2-O-[(tert-butyl)dimethylsilyl]adenosine-3-(2-cyanoethyl-N

N-Benzoyl-5-O-(4

N-diisopropyl)phosphoramidite

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimet...

5'-Dimethoxytrityl-N-benzoyl-Adenosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

TIANFU-CHEM N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

N6-Benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

N6-Benzoyl-5'-O-DMT-2'-O-TBDMS adenosine 3'-CE phosphoramidite

2TBDMS-rA(BZ) Phosphoramidite

N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE

2'-O-TBDMS-A(Bz) CE Phosphoramidite

5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine-3’-Cyanoethyl Phosphoramidite

RNA N-Bz A Amidite

DMT-2'-O-TBDMS-A(Bz)-CE

DMTr-2'-O-TBDMS-rA(Bz)-3'-CE-Phosphoramidite

2’-OTBDMS-rA(Bz) Amidite

5'-ODMT-2'-OTBDMS-N-Bz Adenosine-3'-OCEPA

DMT-2'-0-TBDMS-rA(BZ)

DMT-2'O-TBDMS-rA(bz) Phosphoramidite

2'-O-TBDMS-A(Bz)-CE Phosphoramidite

DMT-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite

5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine 3'-CE phosphoramidite

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

N-(9-[(2R,4R,5R)-5-[(bis(4-methoxyphenyl)(phenyl)methoxy)methyl]-4-{[(bis(propan-2-yl)amino)(2-cyanoethoxy)phosphanyl]oxy}-3-[(tert-butyldimethylsilyl)oxy]oxolan-2-yl]-9H-purin-6-yl)benzamide

N6-Bz-2'-O-TBDMS-5'-O-DMT-A-3'-CE-Phosphoramidite

2'-TBDMS-rA(Bz)Phosphoramidite

5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite

5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine-3’-Cyanoethyl Phosphoramidite

Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

104992-55-4

C53H66N7O8PSi

Pharmaceutical

Amidite