DMT-2'O-TBDMS-rA(bz) Phosphoramidite

Product Name: DMT-2'O-TBDMS-rA(bz) Phosphoramidite
CAS No.: 104992-55-4
Chemical Name: DMT-2'O-TBDMS-rA(bz) Phosphoramidite
Synonyms: Bz-rA Phosphoramidite;2'-TBDMS-A CEP;N-Benzoyl-5-O-(4;RNA N-Bz A Amidite;8-Aza-7-deaza-A CEP;DMT-2'-0-TBDMS-rA(BZ);DMT-2'-O-TBDMS-A(Bz)-CE;2’-OTBDMS-rA(Bz) Amidite;N-diisopropyl)phosphoramidite;2TBDMS-rA(BZ) Phosphoramidite
CBNumber: CB41871629
Molecular Formula: C53H66N7O8PSi
Formula Weight: 988.19
MOL File: 104992-55-4.mol

More

Less

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: powder
pka: 7.87±0.43(Predicted)
color: white to off-white
InChI: InChI=1/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/s3
InChIKey: FFXHNCNNHASXCT-RFMFGJHUSA-N
SMILES: O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](O[Si](C(C)(C)C)(C)C)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,46,55,r|

More

Less

Safety

WGK Germany: 3
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A211050
Product name: DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity: configured for (?KTA? and OligoPilot?)
Packaging: 2g
Price: $188
Updated: 2024/03/01

Sigma-Aldrich

Product number: A211050
Product name: DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity: configured for (?KTA? and OligoPilot?)
Packaging: 10g
Price: $916
Updated: 2024/03/01

Sigma-Aldrich

Product number: A211040
Product name: DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity: configured for MerMade
Packaging: 5G
Price: $372
Updated: 2024/03/01

Sigma-Aldrich

Product number: A211040
Product name: DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity: configured for MerMade
Packaging: 10g
Price: $941
Updated: 2024/03/01

Sigma-Aldrich

Product number: A211000
Product name: DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Packaging: 100g
Price: $7590
Updated: 2024/03/01

More

Less

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Chemical Properties,Usage,Production

Uses

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.

Uses

DMT-2''O-TBDMS-rA(bz) Phosphoramidite (DMT-2'O-TBDMS-rA(bz) Phosphoramidite) is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.

Synthesis

To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 mL) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 ℃. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give DMT-2'O-TBDMS-rA(bz) Phosphoramidite as a white solid (13.0 g. 86% yield)

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Suppliers

Canada 1 China 152 India 3 United Kingdom 2 United States 12 USA 1 Global 171

Hongene Biotech Corporation

Tel: 021-64757213
Fax: 86-21-64700613
Email: info@hongene.com
Country: China
ProdList: 672
Advantage: 61

Wuhu Huaren Science and Technology Co., Ltd.

Tel: 0553-0553-5842013-801 18155347026
Fax: 086-553-5843138
Email: sale@huarensh.com
Country: China
ProdList: 296
Advantage: 64

Shanghai Peinuo Biotechnology Co., Ltd

Tel: 021-58648778 18217200601
Fax: QQ:99286241
Email: bush@perno.cn
Country: China
ProdList: 292
Advantage: 58

Nanjing GoodGene Biotechnology Co., Ltd

Tel: 13335632219
Email: 3152731197@qq.com
Country: China
ProdList: 348
Advantage: 58

Hefei Huana Biomedical Technology Co.,Ltd

Tel: 17333066501
Email: shengwen.fang@huanaok.com.cn
Country: China
ProdList: 95
Advantage: 58

Hefei Stongbio Co.,Ltd.

Tel: 15555170917
Email: sales@stongbio.com
Country: China
ProdList: 457
Advantage: 58

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11660
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696;
Email: info@hanhongsci.com
Country: China
ProdList: 42982
Advantage: 64

More

Less

View Lastest Price from DMT-2'O-TBDMS-rA(bz) Phosphoramidite manufacturers

SHANGHAI NOVRIBO BIOTECH

Product: 2'-O-TBDMS-A(Bz) CE Phosphoramidite;Bz-rA 104992-55-4
Price: US $100.00/kg
Min. Order: 0.009999999776482582kg
Purity: 99%
Supply Ability: 5tons
Release date: 2023-03-21

Hefei Huana Biomedical Technology Co.,Ltd.

Product: N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE 104992-55-4
Price: US $0.00/mg
Min. Order: 100mg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2023-03-09

Henan Aochuang Chemical Co.,Ltd.

Product: Bz-rA Phosphoramidite 104992-55-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-23

104992-55-4, DMT-2'O-TBDMS-rA(bz) PhosphoramiditeRelated Search:

BENZOYL ISOCYANATE Buprofezin ADENOSINE 5'-TRIPHOSPHATASE tert-Butanol Benzoyl chloride Cyhalofop-butyl Benzoyl peroxide Dimethyldimethoxysilane tert-Butyl acetate tert-Butyldimethylsilyl chloride tert-Butyl peroxyacetate N-Benzoylaminopurine 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE TERT-BUTYLDIMETHYLSILANOL N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine N6-BENZYLADENOSINE N6-BENZOYL-3'-DEOXYADENOSINE DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE

DMT-2′O-TBDMS-rA(bz) Phosphoramidite

2'-TBDMS -Bz-rA-CE-Phosphoramidite

5'-DMT-2'-O-TBDMS- N6-Benzoyl-Adenosine Phosphoramidite

(2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite

REF DUPL: 2'-TBDMS-rA(N-Bz)Phosphoramidite

Bz-rA Phosphoramidite

N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 3'-CE phosphoramidite

5'-O-(4,4'-DiMethoxy)-N6-benzoyl-2'-O-(t-butyl diMethylsilyl)adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite

5'-O-DMT-2'-O-TDMS-N6-Bz-Adenosine-3'-CED PhosphoraMidite

Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-[(1,1-diMethylethyl)diMethylsilyl]-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite]

2’-TBDMS-rA(N-Bz) Phosphoramidite

5'-O-DMT-2'-TBDMS-rA(N-Bz)-3'-CEDPA

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide

5'-DMT-2'-TBDMS-rA(N-Bz) Phosphoramidite

5'-O-DMT-2'-O-tert-Butyldimethylsiyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite

8-Aza-7-deaza-A CEP

Adenosine,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-,3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)

5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite

5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine 3'-CE phosphoramidite

2'-TBDMS-A CEP

5'-DMT-2'-TBDMS-N6-Bz-rA phosphoramidite

4-Dimethoxytrityl)-2-O-[(tert-butyl)dimethylsilyl]adenosine-3-(2-cyanoethyl-N

N-Benzoyl-5-O-(4

N-diisopropyl)phosphoramidite

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimet...

5'-Dimethoxytrityl-N-benzoyl-Adenosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

TIANFU-CHEM N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

N6-Benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

N6-Benzoyl-5'-O-DMT-2'-O-TBDMS adenosine 3'-CE phosphoramidite

2TBDMS-rA(BZ) Phosphoramidite

N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE

2'-O-TBDMS-A(Bz) CE Phosphoramidite

5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine-3’-Cyanoethyl Phosphoramidite

RNA N-Bz A Amidite

DMT-2'-O-TBDMS-A(Bz)-CE

DMTr-2'-O-TBDMS-rA(Bz)-3'-CE-Phosphoramidite

2’-OTBDMS-rA(Bz) Amidite

5'-ODMT-2'-OTBDMS-N-Bz Adenosine-3'-OCEPA

DMT-2'-0-TBDMS-rA(BZ)

DMT-2'O-TBDMS-rA(bz) Phosphoramidite

2'-O-TBDMS-A(Bz)-CE Phosphoramidite

DMT-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite

104992-55-4

C53H66N7O8PSi

Pharmaceutical

Amidite