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DMT-2'O-TBDMS-rA(bz) Phosphoramidite

Product Name
DMT-2'O-TBDMS-rA(bz) Phosphoramidite
CAS No.
104992-55-4
Chemical Name
DMT-2'O-TBDMS-rA(bz) Phosphoramidite
Synonyms
Bz-rA Phosphoramidite;2'-TBDMS-A CEP;N-Benzoyl-5-O-(4;RNA N-Bz A Amidite;8-Aza-7-deaza-A CEP;DMT-2'-0-TBDMS-rA(BZ);DMT-2'-O-TBDMS-A(Bz)-CE;2’-OTBDMS-rA(Bz) Amidite;N-diisopropyl)phosphoramidite;2TBDMS-rA(BZ) Phosphoramidite
CBNumber
CB41871629
Molecular Formula
C53H66N7O8PSi
Formula Weight
988.19
MOL File
104992-55-4.mol
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DMT-2'O-TBDMS-rA(bz) Phosphoramidite Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
powder
pka
7.87±0.43(Predicted)
color 
white to off-white
InChI
InChI=1/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/s3
InChIKey
FFXHNCNNHASXCT-RFMFGJHUSA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](O[Si](C(C)(C)C)(C)C)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,46,55,r|
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Safety

WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A211050
Product name
DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity
configured for (?KTA? and OligoPilot?)
Packaging
2g
Price
$188
Updated
2024/03/01
Sigma-Aldrich
Product number
A211050
Product name
DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity
configured for (?KTA? and OligoPilot?)
Packaging
10g
Price
$916
Updated
2024/03/01
Sigma-Aldrich
Product number
A211040
Product name
DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity
configured for MerMade
Packaging
5G
Price
$372
Updated
2024/03/01
Sigma-Aldrich
Product number
A211040
Product name
DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity
configured for MerMade
Packaging
10g
Price
$941
Updated
2024/03/01
Sigma-Aldrich
Product number
A211030
Product name
DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Purity
configured for ABI
Packaging
1g
Price
$84.7
Updated
2024/03/01
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DMT-2'O-TBDMS-rA(bz) Phosphoramidite Chemical Properties,Usage,Production

Uses

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.

Uses

DMT-2''O-TBDMS-rA(bz) Phosphoramidite (DMT-2'O-TBDMS-rA(bz) Phosphoramidite) is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.

Synthesis


To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 mL) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 ℃. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give DMT-2'O-TBDMS-rA(bz) Phosphoramidite as a white solid (13.0 g. 86% yield)

DMT-2'O-TBDMS-rA(bz) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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DMT-2'O-TBDMS-rA(bz) Phosphoramidite Suppliers

Canada 1 China 168 India 3 United Kingdom 2 United States 12 USA 1 Global 187
R&D Scientific Inc.
Tel
+1-2266000236
Email
sales@rdscientific.com
Country
Canada
ProdList
1603
Advantage
58
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View Lastest Price from DMT-2'O-TBDMS-rA(bz) Phosphoramidite manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE 104992-55-4
Price
US $0.00/mg
Min. Order
100mg
Purity
≥98%
Supply Ability
20tons
Release date
2023-03-09
Shaanxi Dideu Medichem Co. Ltd
Product
N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 104992-55-4
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24
SHANGHAI NOVRIBO BIOTECH
Product
2'-O-TBDMS-A(Bz) CE Phosphoramidite;Bz-rA 104992-55-4
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-21

104992-55-4, DMT-2'O-TBDMS-rA(bz) PhosphoramiditeRelated Search:

BENZOYL ISOCYANATE Buprofezin ADENOSINE 5'-TRIPHOSPHATASE tert-Butanol Benzoyl chloride Cyhalofop-butyl Benzoyl peroxide Dimethyldimethoxysilane tert-Butyl acetate tert-Butyldimethylsilyl chloride tert-Butyl peroxyacetate N-Benzoylaminopurine 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE TERT-BUTYLDIMETHYLSILANOL N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine N6-BENZYLADENOSINE N6-BENZOYL-3'-DEOXYADENOSINE DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE

  • DMT-2′O-TBDMS-rA(bz) Phosphoramidite
  • 2'-TBDMS -Bz-rA-CE-Phosphoramidite
  • 5'-DMT-2'-O-TBDMS- N6-Benzoyl-Adenosine Phosphoramidite
  • (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
  • REF DUPL: 2'-TBDMS-rA(N-Bz)Phosphoramidite
  • Bz-rA Phosphoramidite
  • N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 3'-CE phosphoramidite
  • 5'-O-(4,4'-DiMethoxy)-N6-benzoyl-2'-O-(t-butyl diMethylsilyl)adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite
  • 5'-O-DMT-2'-O-TDMS-N6-Bz-Adenosine-3'-CED PhosphoraMidite
  • Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-[(1,1-diMethylethyl)diMethylsilyl]-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite]
  • 2’-TBDMS-rA(N-Bz) Phosphoramidite
  • 5'-O-DMT-2'-TBDMS-rA(N-Bz)-3'-CEDPA
  • N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide
  • 5'-DMT-2'-TBDMS-rA(N-Bz) Phosphoramidite
  • 5'-O-DMT-2'-O-tert-Butyldimethylsiyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite
  • 8-Aza-7-deaza-A CEP
  • Adenosine,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-,3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)
  • 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite
  • 5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine 3'-CE phosphoramidite
  • 2'-TBDMS-A CEP
  • 5'-DMT-2'-TBDMS-N6-Bz-rA phosphoramidite
  • 4-Dimethoxytrityl)-2-O-[(tert-butyl)dimethylsilyl]adenosine-3-(2-cyanoethyl-N
  • N-Benzoyl-5-O-(4
  • N-diisopropyl)phosphoramidite
  • N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimet...
  • 5'-Dimethoxytrityl-N-benzoyl-Adenosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • TIANFU-CHEM N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • N6-Benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • N6-Benzoyl-5'-O-DMT-2'-O-TBDMS adenosine 3'-CE phosphoramidite
  • 2TBDMS-rA(BZ) Phosphoramidite
  • N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE
  • 2'-O-TBDMS-A(Bz) CE Phosphoramidite
  • 5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine-3’-Cyanoethyl Phosphoramidite
  • RNA N-Bz A Amidite
  • DMT-2'-O-TBDMS-A(Bz)-CE
  • DMTr-2'-O-TBDMS-rA(Bz)-3'-CE-Phosphoramidite
  • 2’-OTBDMS-rA(Bz) Amidite
  • 5'-ODMT-2'-OTBDMS-N-Bz Adenosine-3'-OCEPA
  • DMT-2'-0-TBDMS-rA(BZ)
  • DMT-2'O-TBDMS-rA(bz) Phosphoramidite
  • 2'-O-TBDMS-A(Bz)-CE Phosphoramidite
  • DMT-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite
  • 5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine 3'-CE phosphoramidite
  • N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)
  • N-(9-[(2R,4R,5R)-5-[(bis(4-methoxyphenyl)(phenyl)methoxy)methyl]-4-{[(bis(propan-2-yl)amino)(2-cyanoethoxy)phosphanyl]oxy}-3-[(tert-butyldimethylsilyl)oxy]oxolan-2-yl]-9H-purin-6-yl)benzamide
  • N6-Bz-2'-O-TBDMS-5'-O-DMT-A-3'-CE-Phosphoramidite
  • 2'-TBDMS-rA(Bz)Phosphoramidite
  • 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite
  • 5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine-3’-Cyanoethyl Phosphoramidite
  • Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
  • 104992-55-4
  • C53H66N7O8PSi
  • Pharmaceutical
  • Amidite