DMT-2'O-TBDMS-rA(bz) Phosphoramidite
- Product Name
- DMT-2'O-TBDMS-rA(bz) Phosphoramidite
- CAS No.
- 104992-55-4
- Chemical Name
- DMT-2'O-TBDMS-rA(bz) Phosphoramidite
- Synonyms
- Bz-rA Phosphoramidite;2'-TBDMS-A CEP;N-Benzoyl-5-O-(4;RNA N-Bz A Amidite;8-Aza-7-deaza-A CEP;DMT-2'-0-TBDMS-rA(BZ);DMT-2'-O-TBDMS-A(Bz)-CE;2’-OTBDMS-rA(Bz) Amidite;N-diisopropyl)phosphoramidite;2TBDMS-rA(BZ) Phosphoramidite
- CBNumber
- CB41871629
- Molecular Formula
- C53H66N7O8PSi
- Formula Weight
- 988.19
- MOL File
- 104992-55-4.mol
DMT-2'O-TBDMS-rA(bz) Phosphoramidite Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- powder
- pka
- 7.87±0.43(Predicted)
- color
- white to off-white
- InChI
- InChI=1/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/s3
- InChIKey
- FFXHNCNNHASXCT-RFMFGJHUSA-N
- SMILES
- O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](O[Si](C(C)(C)C)(C)C)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,46,55,r|
Safety
- WGK Germany
- 3
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A211050
- Product name
- DMT-2′O-TBDMS-rA(bz) Phosphoramidite
- Purity
- configured for (?KTA? and OligoPilot?)
- Packaging
- 2g
- Price
- $188
- Updated
- 2024/03/01
- Product number
- A211050
- Product name
- DMT-2′O-TBDMS-rA(bz) Phosphoramidite
- Purity
- configured for (?KTA? and OligoPilot?)
- Packaging
- 10g
- Price
- $916
- Updated
- 2024/03/01
- Product number
- A211040
- Product name
- DMT-2′O-TBDMS-rA(bz) Phosphoramidite
- Purity
- configured for MerMade
- Packaging
- 5G
- Price
- $372
- Updated
- 2024/03/01
- Product number
- A211040
- Product name
- DMT-2′O-TBDMS-rA(bz) Phosphoramidite
- Purity
- configured for MerMade
- Packaging
- 10g
- Price
- $941
- Updated
- 2024/03/01
- Product number
- A211000
- Product name
- DMT-2′O-TBDMS-rA(bz) Phosphoramidite
- Packaging
- 100g
- Price
- $7590
- Updated
- 2024/03/01
DMT-2'O-TBDMS-rA(bz) Phosphoramidite Chemical Properties,Usage,Production
Uses
N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.
Uses
DMT-2''O-TBDMS-rA(bz) Phosphoramidite (DMT-2'O-TBDMS-rA(bz) Phosphoramidite) is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.
Synthesis
To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 mL) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 ℃. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give DMT-2'O-TBDMS-rA(bz) Phosphoramidite as a white solid (13.0 g. 86% yield)
DMT-2'O-TBDMS-rA(bz) Phosphoramidite Preparation Products And Raw materials
Raw materials
Preparation Products
DMT-2'O-TBDMS-rA(bz) Phosphoramidite Suppliers
- Tel
- 021-64757213
- Fax
- 86-21-64700613
- info@hongene.com
- Country
- China
- ProdList
- 672
- Advantage
- 61
- Tel
- 0553-0553-5842013-801 18155347026
- Fax
- 086-553-5843138
- sale@huarensh.com
- Country
- China
- ProdList
- 296
- Advantage
- 64
- Tel
- 021-58648778 18217200601
- Fax
- QQ:99286241
- bush@perno.cn
- Country
- China
- ProdList
- 292
- Advantage
- 58
- Tel
- 13335632219
- 3152731197@qq.com
- Country
- China
- ProdList
- 348
- Advantage
- 58
- Tel
- 17333066501
- shengwen.fang@huanaok.com.cn
- Country
- China
- ProdList
- 95
- Advantage
- 58
- Tel
- 15555170917
- sales@stongbio.com
- Country
- China
- ProdList
- 457
- Advantage
- 58
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44751
- Advantage
- 61
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- zhangsn@titansci.com
- Country
- China
- ProdList
- 14113
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11660
- Advantage
- 64
- Tel
- 021-54306202 13764082696;
- info@hanhongsci.com
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 021-61551611 13296011611
- Fax
- +86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9900
- Advantage
- 58
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10269
- Advantage
- 58
- Tel
- 021-50430803 18017383231
- Fax
- qq:2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9352
- Advantage
- 55
- Tel
- 25-25-58740604 15951658055
- Fax
- +86-25-58356858
- sales@unisyn.cn
- Country
- China
- ProdList
- 537
- Advantage
- 58
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9352
- Advantage
- 58
- Tel
- 18040571231/1402788087
- Fax
- sales@chemduro.com
- Country
- China
- ProdList
- 1973
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9636
- Advantage
- 58
- Tel
- 400-6087598 15021221957
- Fax
- 4006087598-8012
- order@canspecsci.com
- Country
- China
- ProdList
- 2071
- Advantage
- 56
- Tel
- 86-574-27787657
- Fax
- 86-574-27912196
- info@dearchem.com
- Country
- China
- ProdList
- 4619
- Advantage
- 58
- Tel
- +86-571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 10015
- Advantage
- 53
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12357
- Advantage
- 58
- Tel
- 86(21)68097365
- Fax
- 86(21)33321566
- sales@anpharma.net
- Country
- China
- ProdList
- 4901
- Advantage
- 55
- Tel
- 0553-8233716 18055326116
- sales@nuowei-chem.com
- Country
- China
- ProdList
- 950
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27322
- Advantage
- 60
- Tel
- +86 512 86668828 ,8026
- Fax
- +86 512 86668828
- chem@genepharma.com
- Country
- China
- ProdList
- 46
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 027-50664929, 13971561712
- Fax
- 027-50664927 / QQ: 3452835437
- hubxys2001@163.com
- Country
- China
- ProdList
- 1437
- Advantage
- 55
- Tel
- 027-027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 3979
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28822
- Advantage
- 58
- Tel
- 021-021-58950110 13124863828
- Fax
- 021-20922272
- sales@linkchem.cn
- Country
- China
- ProdList
- 3000
- Advantage
- 58
- Tel
- 0755-0755-85201366 18938635012
- Fax
- 0755-85201366
- sales@regentsciences.com
- Country
- China
- ProdList
- 9293
- Advantage
- 58
- Tel
- 571-85586718 +8613336195806
- Fax
- +86-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 29797
- Advantage
- 60
- Tel
- 025-66113011 18112977050
- Fax
- (5)02557626880
- cb6@aikonchem.com
- Country
- China
- ProdList
- 15495
- Advantage
- 58
- Tel
- 13331045123
- Fax
- 86-10-80339217
- 1963319514@qq.com
- Country
- China
- ProdList
- 14234
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 24971
- Advantage
- 58
- Tel
- 0531-61320525 15866703830
- 495745175@qq.com
- Country
- China
- ProdList
- 6890
- Advantage
- 58
- Tel
- 027-51831887 15337167856
- Fax
- 027-51837635 QQ1165326703
- hubeixinyuanshun@163.com
- Country
- China
- ProdList
- 10305
- Advantage
- 58
- Tel
- 18913822354
- market@geneyan-bio.com
- Country
- China
- ProdList
- 299
- Advantage
- 58
- Tel
- 18367600069
- Fax
- QQ3388371646
- pinghushizy@163.com
- Country
- China
- ProdList
- 7813
- Advantage
- 58
- Tel
- 15966937598
- Fax
- 3407640895 3071519937
- 3407650895@qq.com
- Country
- China
- ProdList
- 1002
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- 13764598896
- grace8018@163.com
- Country
- China
- ProdList
- 296
- Advantage
- 58
- Tel
- 021-021-56152668 18116302010
- Fax
- 18116300787
- sharing@sharingtechcn.com
- Country
- China
- ProdList
- 502
- Advantage
- 58
- Tel
- 025-86506625 13915545693
- Fax
- 0517-86993111
- info@szsep.com
- Country
- China
- ProdList
- 64
- Advantage
- 58
- Tel
- 010-82387566 18001021521;
- Fax
- 82387566-801
- sales@mreda.com.cn
- Country
- China
- ProdList
- 21450
- Advantage
- 58
- Tel
- 0731-85567275 19313119731
- sales@chemfish.com
- Country
- China
- ProdList
- 4918
- Advantage
- 58
- Tel
- +86-023-62871537
- sales@rosewachem.com
- Country
- China
- ProdList
- 2830
- Advantage
- 58
- Tel
- +8615866703830
- figo.gao@foxmail.com
- Country
- China
- ProdList
- 7019
- Advantage
- 58
View Lastest Price from DMT-2'O-TBDMS-rA(bz) Phosphoramidite manufacturers
- Product
- 2'-O-TBDMS-A(Bz) CE Phosphoramidite;Bz-rA 104992-55-4
- Price
- US $100.00/kg
- Min. Order
- 0.009999999776482582kg
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2023-03-21
- Product
- N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE 104992-55-4
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- ≥98%
- Supply Ability
- 20tons
- Release date
- 2023-03-09
- Product
- Bz-rA Phosphoramidite 104992-55-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-23