DMT-2′Fluoro-dU Phosphoramidite

Product Name: DMT-2′Fluoro-dU Phosphoramidite
CAS No.: 146954-75-8
Chemical Name: DMT-2′Fluoro-dU Phosphoramidite
Synonyms: 2‘-F-U amidite;2'-Fluoro-dU CEP;2’-F-dU Amidite;2’-F-rUPhosphoramidite;2'-F-U Phosphoramidite;2'-F-dU Phosphoramidite;5'-O-DMT-2'-fluoro-dU-CE;5'-O-DMT-2'-F-dU-3'-CEDPA;2'-Fluoro Uridine Amidite;2'-Fluoro Uridine Amidite
CBNumber: CB8500324
Molecular Formula: C39H46FN4O8P
Formula Weight: 748.78
MOL File: 146954-75-8.mol

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DMT-2′Fluoro-dU Phosphoramidite Property

storage temp.: Sealed in dry,Store in freezer, under -20°C
form: powder
pka: 9.39±0.10(Predicted)
color: white to off-white
InChI: InChI=1/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-24-10-22-41)52-36-33(51-37(35(36)40)43-23-21-34(45)42-38(43)46)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,42,45,46)/t33-,35-,36-,37-,53?/s3
InChIKey: HQHQPAYRJJMYQX-YOKGOYKLNA-N
SMILES: N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2C=CC(=CC=2)OC)C2=CC=C(C=C2)OC)[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@H]1F |&1:8,10,36,51,r|

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: U211280
Product name: DMT-2′Fluoro-dU Phosphoramidite
Purity: configured for PerkinElmer, configured for Polygen
Packaging: 1G
Price: $206
Updated: 2024/03/01

Sigma-Aldrich

Product number: U211250
Product name: DMT-2′Fluoro-dU Phosphoramidite
Purity: configured for (?KTA? and OligoPilot?)
Packaging: 1G
Price: $219
Updated: 2024/03/01

Sigma-Aldrich

Product number: U211200
Product name: DMT-2′Fluoro-dU Phosphoramidite
Purity: ≥99% (31P-NMR)
Packaging: 100g
Price: $8200
Updated: 2024/03/01

Sigma-Aldrich

Product number: U211200
Product name: DMT-2′Fluoro-dU Phosphoramidite
Purity: ≥99% (31P-NMR)
Packaging: 500g
Price: $36650
Updated: 2024/03/01

Sigma-Aldrich

Product number: U211280
Product name: DMT-2′Fluoro-dU Phosphoramidite
Purity: configured for PerkinElmer, configured for Polygen
Packaging: 2g
Price: $383
Updated: 2024/03/01

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DMT-2′Fluoro-dU Phosphoramidite Chemical Properties,Usage,Production

Uses

5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite (DMT-2′Fluoro-dU Phosphoramidite) is a uridine phosphoramidite consisting of a fluorine in the 2' position, and the compound is used in the synthesis of DNA.

Definition

DMT-2′Fluoro-dU Phosphoramidite is also known as 2'-F-U CE-Phosphoramidite. 2'-F-RNA oligonucleotides adopt an A-form helix on hybridisation to a target. Whereas a hydroxyl group of RNA is a hydrogen bond donor, fluorine appears to be a weak acceptor. These features of 2'-F-RNA oligonucleotides lead to certain interesting properties. For example, it was demonstrated that oligonucleotides hybridise to a RNA oligonucleotide in the following order of increasing stability: DNA < RNA < 2'-OMe-RNA < 2'-F-RNA

Synthesis

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine (3.00 g, 5.47 mmol) was dissolved in anhydrous dichloromethane (50 ml) under an argon atmosphere, N,N-diisopropylethylamine (0.55 ml,3.18 mmol), 1H-tetrazole (0.45 g, 6.45 mmol) and 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite (1.92 g, 6.36mmol) were added. And the mixture was stirred at room temperature overnight. The completion of the reaction was confirmed, 5 percent aqueous sodium hydrogen carbonate solution (20 ml) was added to the reaction mixture to allow layer separation, and the organic layer was washed with saturated brine (20 ml). The organic layer was dried over sodium sulfate, the filtrate was concentrated and the obtained crude product was purified by silica gel chromatography (hexane:ethyl acetate=75:25 - 30/70(v/v), containing 3percent triethylamine). The object fractions were collected and concentratedto give DMT-2′Fluoro-dU Phosphoramidite (2.76 g, 67.3 percent).

DMT-2′Fluoro-dU Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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DMT-2′Fluoro-dU Phosphoramidite Suppliers

Canada 1 China 147 India 5 Switzerland 1 United Kingdom 2 United States 12 Global 168

SIGMA-RBI

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View Lastest Price from DMT-2′Fluoro-dU Phosphoramidite manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.

Product: 5'-O-DMT-2'-fluoro-dU-CE 146954-75-8
Price: US $0.00/mg
Min. Order: 100mg
Purity: ≥99%
Supply Ability: 20tons
Release date: 2023-03-09

R&D Scientific Inc.

Product: 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit 146954-75-8
Price: US $1550.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-02-10

SHANGHAI NOVRIBO BIOTECH

Product: 2'-F-dU CE Phosphoramidite 146954-75-8
Price: US $100.00/kg
Min. Order: 0.009999999776482582kg
Purity: 99%
Supply Ability: 5tons
Release date: 2023-03-21

146954-75-8, DMT-2′Fluoro-dU PhosphoramiditeRelated Search:

3-Chloropropyltrimethoxysilane Doxifluridine 1-beta-D-Arabinofuranosyluracil Pseudouridine 3-Chloropropyltriethoxysilane 3-Aminopropyltriethoxysilane Floxuridine 5-Fluorouridine DMT-dG(ib) Phosphoramidite DMT-dA(bz) Phosphoramidite DMT-2'O-Methyl-rU Phosphoramidite DMT-2'O-TBDMS-rA(bz) Phosphoramidite DMT-dG(dmf) Phosphoramidite 3'-TBDMS-ibu-rG Phosphoramidite Ac-rC Phosphoramidite Uridine DMT-2′Fluoro-dU Phosphoramidite

3-({[(2-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-5-(2,4-DIOXO-3H-PYRIMIDIN-1-YL)-4-FLUOROOXOLAN

2'-Fluoro-5'-O-DMT-2'-deoxyuridine-3'-CE-Phosphoramidite

5'-DMT-2'-F-rU Phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite

2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine Phosphoramidite

DMT-2'-F-DU AMIDITE 0.25G, AB, SINGLE

DMT-2'-F-dU Amidite 0.25g, 89, Single

2’-F-rUPhosphoramidite

5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

5'-O-DMT-2'-F-dU-3'-CEDPA

2'-F-dU Phosphoramidite

2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine-3'-CED PhosphoraMidite

DMT-2′Fluoro-dU Phosphoramidite

5'-O-DMT-2'-Fluoro-2'-deoxyuridine 3'-CE phosphoramidite

2'-Fluoro-dU CEP

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

5'-Dimethoxytrityl-deoxyUridine, 2'-fluoro-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

2'-Fluoro-N2-Isobutyryl-5'-O-DMT-2'-Deoxyguanosine-3'-CE-Phosphoramidite

5'-DMTr-2'-F-3'-O-CEP-URIDINE

5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite

5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit

2‘-F-U amidite

DMT-2'-F-U Phosphoramidite

DMT-2’-F-dU-CE Phosphoramidite

5'-O-DMT-2'-fluoro-dU-CE

Inhibitor,Nucleoside Antimetabolite/Analog,DMT2′FluorodU Phosphoramidite,inhibit,DMT 2′Fluoro dU Phosphoramidite

5'-O-DMT-2'-F-2'-Deoxy Uridine -3’-Cyanoethyl Phosphoramidite

2'-Fluoro Uridine Amidite

3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-tetrahydrofuran-3-yl]oxy-(diisopropylamino)phosphanyl]oxypropanenitrile

DMTr-2'-F-dU-3'-CE-Phosphoramidite

2’-F-dU Amidite

5'-O-(4, 4'-dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-CE-Phosphoramidite

5'-ODMT-2'-Fluoro uridine-3'-OCEPA

2'-F-U Phosphoramidite

DMT-2'-F-dU-CE Phosphoramidite

5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit

2'-Fluoro-2'-deoxy Uridine CED Phosphoramidite

2'-F-5'-O-DMT-2'-dU-3'-CE-Phosphoramidite

DMTr-2'-F-dU-3'-CE-Phosphoramidite

5'-O-DMT-2'-fluoro-2'-Deoxyuridine 3'-CE phosphoramidite

5'-O-DMT-2'-F-2'-Deoxy Uridine -3’-Cyanoethyl Phosphoramidite

2'-Fluoro Uridine Amidite

DMT-2'FLUORO-DU PHOSPHORAMIDITE

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

146954-75-8

Amidite