2'-Fluoro-2'-deoxyuridine
- Product Name
- 2'-Fluoro-2'-deoxyuridine
- CAS No.
- 784-71-4
- Chemical Name
- 2'-Fluoro-2'-deoxyuridine
- Synonyms
- 2'-FU;2-FdU;2'-FUDR;2'-F-2'-dU;Fioluridine;2'-FLUORO-D-URIDINE;2'-Fluoro-2'-deoxyur;2'-F-2'-deoxyuridine;2'-F-2'-deoxyuridine;2 '- Fluorodeoxyuridine
- CBNumber
- CB3358175
- Molecular Formula
- C9H11FN2O5
- Formula Weight
- 246.19
- MOL File
- 784-71-4.mol
2'-Fluoro-2'-deoxyuridine Property
- Melting point:
- 147.0 to 153.0 °C
- Density
- 1.63±0.1 g/cm3(Predicted)
- refractive index
- 53 ° (C=0.3, H2O)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in methanol.
- form
- Powder
- pka
- 9.39±0.10(Predicted)
- color
- White to Off-white
- optical activity
- α20/D +53°±3°, c = 0.3 in water
- Water Solubility
- soluble in water
- InChI
- InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1
- InChIKey
- UIYWFOZZIZEEKJ-XVFCMESISA-N
- SMILES
- OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O
- CAS DataBase Reference
- 784-71-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-40
- Safety Statements
- 22-36/37/39
- HS Code
- 29389090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- D3615
- Product name
- 2'-Deoxy-2'-fluorouridine
- Purity
- >97.0%(HPLC)
- Packaging
- 1g
- Price
- $31
- Updated
- 2024/03/01
- Product number
- D3615
- Product name
- 2'-Deoxy-2'-fluorouridine
- Purity
- >97.0%(HPLC)
- Packaging
- 5g
- Price
- $121
- Updated
- 2024/03/01
- Product number
- J65948
- Product name
- 2'-Fluoro-2'-deoxyuridine, 97%
- Packaging
- 1g
- Price
- $28.65
- Updated
- 2024/03/01
- Product number
- J65948
- Product name
- 2'-Fluoro-2'-deoxyuridine, 97%
- Packaging
- 5g
- Price
- $104.65
- Updated
- 2024/03/01
- Product number
- J65948
- Product name
- 2'-Fluoro-2'-deoxyuridine, 97%
- Packaging
- 25g
- Price
- $405.65
- Updated
- 2024/03/01
2'-Fluoro-2'-deoxyuridine Chemical Properties,Usage,Production
Description
2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity.
Chemical Properties
White to almost white crystalline powder
Uses
2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.
Uses
A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.
Synthesis
Method for the synthesis of 2'-Fluoro-2'-deoxyuridine, comprising the following steps:
(1) Uridine, diphenyl carbonate was added in dimethylformamide, dissolved at elevated temperature, the solution was clarified, the catalyst sodium bicarbonate was added under the condition of maintaining temperature, the reaction was carried out at elevated temperature for the second time, the reaction was completed, the temperature was cooled down naturally to room temperature, stirred, filtered, and the cake was dried to obtain compound 2.
(2) Compound 2, anhydrous potassium fluoride, catalyst boron trifluoride ethyl ether dissolved in a solvent, temperature rise reaction, after the completion of the reaction, filtration and concentration, to obtain 2'-fluoro-2'-deoxyuridine.
However, the hydroxyl conversion rate of this method is low, 2'-fluoro-2'-deoxyuridine is an extremely viscous compound, and it cannot be cured and purified when the purity is not high, resulting in the need for the method to be purified by passing through a column at a later stage, and it cannot be used in a factory for continuous and scaled-up production.
2'-Fluoro-2'-deoxyuridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2'-Fluoro-2'-deoxyuridine manufacturers
- Product
- 2'-Deoxy-2'-fluorouridine 784-71-4
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20Ton
- Release date
- 2024-11-01
- Product
- 2'-Fluoro-2'-Deoxyuridine 784-71-4
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5ton
- Release date
- 2024-04-22
- Product
- 2'-Fluoro-2'-deoxyuridine 784-71-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-08