Ethyl 2-Chlorobenzoate

Ethyl 2-Chlorobenzoate Property

Boiling point:

241-243 °C(lit.)

Density 

1.18 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.523(lit.)

Flash point:

>230 °F

storage temp. 

Store at room temperature

form 

clear liquid

color 

Colorless to Almost colorless

Specific Gravity

1.180

BRN 

2207359

CAS DataBase Reference

7335-25-3(CAS DataBase Reference)

EPA Substance Registry System

Benzoic acid, 2-chloro-, ethyl ester (7335-25-3)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

HS Code 

29163990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

Ethyl 2-Chlorobenzoate Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to pale yellow liquid

Synthesis

GENERAL PROCEDURE: In a dry Schlenk tube, sodium hydride (6.0 mmol) was stirred with ethyl trifluoroacetate (6.0 mmol) in tetrahydrofuran (5 mL) for 10 minutes at room temperature under argon protection. Subsequently, a solution of enolizable ketone (5.0 mmol) in tetrahydrofuran (5 mL) was slowly added dropwise to the above mixture at 0°C and under argon atmosphere. The reaction solution was stirred at a set temperature for 2 to 6 hours before being cooled again to 0°C and the reaction was quenched with 6 mL of a 1 mol/L hydrochloric acid solution. After continued stirring for 15 minutes, the mixture was neutralized with saturated sodium bicarbonate solution. After conventional post-treatment steps, the residue was purified by silica gel column chromatography to give the target product trifluoromethyl alkyl ketone.

References

[1] Tetrahedron, 2014, vol. 70, # 31, p. 4668 - 4674