5-CHLORO-2-METHYLPHENYLBORONIC ACID
- Product Name
- 5-CHLORO-2-METHYLPHENYLBORONIC ACID
- CAS No.
- 148839-33-2
- Chemical Name
- 5-CHLORO-2-METHYLPHENYLBORONIC ACID
- Synonyms
- 5-CHLORO-2-METHYLPHE;5-Chloro-o-tolylboronic Acid;5-Chloro-2-methylphenylboronicaci;2-METHYL-5-CHLOROPHENYLBORONICACID;5-CHLORO-2-METHYLPHENYLBORONIC ACID;5-Chloro-2-Methylphenyl boconic acid;5-CHLORO-2-METHYLBENZENEBORONIC ACID;5-Chloro-2-methylphenyl boronic acid ,97%;Boronic acid, B-(5-chloro-2-methylphenyl)-;5-Chloro-2-methylphenylboronic acid - [C2230]
- CBNumber
- CB6161657
- Molecular Formula
- C7H8BClO2
- Formula Weight
- 170.4
- MOL File
- 148839-33-2.mol
5-CHLORO-2-METHYLPHENYLBORONIC ACID Property
- Melting point:
- 162-166
- Boiling point:
- 328.0±52.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 7.63±0.58(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 148839-33-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22-36-22
- Safety Statements
- 26-36/37/39-36-60-37
- Hazard Note
- Irritant
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2665
- Product name
- 5-Chloro-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $44
- Updated
- 2025/07/31
- Product number
- C2665
- Product name
- 5-Chloro-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $155
- Updated
- 2025/07/31
- Product number
- C587468
- Product name
- 5-Chloro-2-methylphenylboronicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-W000875
- Product name
- (5-Chloro-2-methylphenyl)boronicacid
- Purity
- 99.64%
- Packaging
- 25g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- 40311
- Product name
- 5-Chloro-2-methylphenylboronicacid,97-105%(Assaybytitration)
- Purity
- 97-105%(Assaybytitration)
- Packaging
- 1G
- Price
- $38.08
- Updated
- 2021/12/16
5-CHLORO-2-METHYLPHENYLBORONIC ACID Chemical Properties,Usage,Production
Chemical Properties
Off-white Cryst
Uses
suzuki reaction
Synthesis
121-43-7
33184-48-4
148839-33-2
The general procedure for the synthesis of 5-chloro-2-methylphenylboronic acid from trimethyl borate and 4-chloro-2-iodotoluene was carried out as follows: firstly, magnesium shavings (0.346 g, 14.25 mmol) were activated by heating in an oven at 120°C for 16 hours. Anhydrous tetrahydrofuran (50 ml) and a small amount of iodine crystals were added to the activated magnesium crumbs using pre-oven dried glassware. Subsequently, 4-chloro-2-iodotoluene was added via syringe and the reaction system was ensured to be in an oxygen-free environment. The reaction mixture was heated and refluxed for 5.5 hours under a continuous flow of argon gas. Upon completion of the reaction, the system was cooled to -78°C (using a dry ice-acetone bath) and a solution of anhydrous tetrahydrofuran (10 ml) of trimethyl borate (2.47 g, 23.76 mmol) was slowly added dropwise. After the dropwise addition, the reaction system was allowed to warm up slowly to room temperature and stirring was continued for 16 hours. At the end of the reaction, the reaction was quenched by careful addition of 1 M hydrochloric acid (20 ml), followed by extraction of the reaction mixture with ether (3 x 50 ml). The organic phases were combined, washed with water (3 x 50 ml), dried with magnesium sulfate and concentrated under reduced pressure. Finally, the residue was washed with hexane to afford the target product 5-chloro-2-methylphenylboronic acid (0.537 g, 26% yield) as a white powder.
References
[1] Patent: US2004/204386, 2004, A1
5-CHLORO-2-METHYLPHENYLBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CHLORO-2-METHYLPHENYLBORONIC ACID manufacturers
- Product
- 5-CHLORO-2-METHYLPHENYLBORONIC ACID 148839-33-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg;5kg;100kg
- Release date
- 2019-07-04