ChemicalBook > CAS DataBase List > (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE

Product Name
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
CAS No.
39637-99-5
Chemical Name
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
Synonyms
MOSHER'S ACID CHLORIDE;(-)-Mosher's Acid Chloride;(+)-MTPA-CL;(R)-(−(S)-(+)-MTPA-CL;(R)-MTPA chloride;(R)-(-)-Acid chloride;(+)-MOSHER'S CHLORIDE;(+)-MOSHER'S ACID CHLORIDE;(R)-(-)-Mosher'sacidchloride
CBNumber
CB6170769
Molecular Formula
C10H8ClF3O2
Formula Weight
252.62
MOL File
39637-99-5.mol
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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Property

Boiling point:
213-214 °C(lit.)
alpha 
D25 -10.0± 0.1° (neat, l = 1)
Density 
1.35 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.469(lit.)
Flash point:
194 °F
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
Liquid
Specific Gravity
1.353
color 
Clear colorless to light yellow
optical activity
[α]20/D 137±2°, c = 6.4% in carbon tetrachloride
Water Solubility 
Sparingly miscible with water.
Sensitive 
Moisture Sensitive
Merck 
14,6280
BRN 
3591565
CAS DataBase Reference
39637-99-5(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-27-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
F 
10-21
Hazard Note 
Corrosive/Freeze
HazardClass 
8
PackingGroup 
II
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
65363
Product name
(R)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride
Purity
for chiral derivatization, ≥99.0%
Packaging
100mg
Price
$154
Updated
2025/07/31
Sigma-Aldrich
Product number
65363
Product name
(R)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride
Purity
for chiral derivatization, ≥99.0%
Packaging
500mg
Price
$608
Updated
2025/07/31
TCI Chemical
Product number
M1104
Product name
(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
Purity
>98.0%(GC)
Packaging
100mg
Price
$55
Updated
2025/07/31
TCI Chemical
Product number
M1104
Product name
(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
Purity
>98.0%(GC)
Packaging
1g
Price
$322
Updated
2025/07/31
TCI Chemical
Product number
M2215
Product name
(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride (ca. 18% in Dichloromethane, ca. 1.0mol/L) [for Determination of the optical purity of Alcohols and Amines]
Packaging
5g
Price
$548
Updated
2025/07/31
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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is used as a chiral acylating reagent, which is used in the resolution of amino acid enantiomers like 2,5-dimethoxy-4-methylamphetamine. It is also suitable for the determination of the optical composition of compounds extracted from biological fluids.

Purification Methods

The most likely impurity is the free acid due to hydrolysis and should be checked by IR. If free from acid, then distil, taking care to keep moisture out of the apparatus. Otherwise add SOCl2 and reflux for 5hours and distil it. Note that shorter reflux times result in a higher boiling fraction (b 130-155o/1mm) which has been identified as the anhydride. [Dale et al. J Org Chem 34 2543 1969, for enantiomeric purity see Dale & Mosher J Am Chem Soc 97 512 1973.]

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Suppliers

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View Lastest Price from (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE manufacturers

Career Henan Chemical Co
Product
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 39637-99-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

39637-99-5, (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDERelated Search:

3,3,3-TRIFLUOROPROPIONYL CHLORIDE Phenylacetyl chloride 1-PHENYL-2,2,2-TRIFLUOROETHANOL 1-Pentanol (+/-)-2-CHLORO-1-PHENYLETHANOL (S)-1-Chloro-2-propanol 1-CHLORO-3-FLUOROISOPROPANOL (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE,ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 3-CHLORO-1,1,1-TRIFLUOROPROPANE (R)-1-Chloro-2-propanol 1-CHLORO-2-METHYL-2-PROPANOL Acetyl chloride 3,3,3-Trifluoropropionic acid Methoxyacetyl chloride (R)-(-)-ALPHA-(TRIFLUOROMETHYL)BENZYL ALCOHOL

  • (R)-(fi)-alpha-methoxy-alpha-trifluoromethylphenylacetylchloride
  • (R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%
  • (R)-(-)-MTPA-Cl, Moshers acid chloride
  • (S)-2-Methoxy-2-phenyl-3,3,3-trifluoropropionic acid chloride
  • (S)-2-Methoxy-3,3,3-trifluoro-2-phenylpropionic acid chloride
  • (S)-2-Phenyl-2-methoxy-3,3,3-trifluoropropionic acid chloride
  • [S,(+)]-α-Methoxy-α-(trifluoromethyl)benzeneacetic acid chloride
  • (R)-(-)-^a-Methoxy-^a-(trifluoromethyl)phenylacetyl chloride, 98+%
  • (R)-(-)-α-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride
  • (R)-(-)-α-Methoxy-α-(trifluoromethyl)benzeneacetylchloride (-)-MTPA-Cl
  • (R)-()-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride,(R)-()-MTPA-Cl, Mosher’s acid chloride
  • (1R)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride 99% (99%ee)
  • (R)-(-)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride, 97+%
  • (2R)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99% (99%ee)
  • (R)-(-)-MTPACl, (R)-(-)-Mosher's acid chloride, (2R)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropionyl chloride
  • (-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetyl Chloride&nbsp
  • [for DeterMination of the optical purity of Alcohols and AMines]
  • (R)-2-Methoxy-2-(trifluoromethyl)phenylacetyl chloride
  • (2R)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoylchloride99%
  • (R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride,99%
  • (2R)-(-)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99%
  • (R)-(-)-alphaMethoxy-alpha(three fluoroMethyl)phenyl acetyl chloride
  • (R)-MTPA chloride
  • (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride
  • (R)-(-)-Acid chloride
  • (R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride (ca. 18% in Dichloromethane, ca. 1.0mol/L) [for Determination of the optical purity of Alcohols and Amines]
  • (R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
  • (R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride, 99%, 18wt.% solution in dichloromethane
  • (R)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)-PH ENYLACETYL CHLORIDE, 98%(98% EE/GLC)
  • (R)-(-)-Mosher'sacidchloride
  • (R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetylchloride(ee)
  • (-)--Methoxy--(trifluoromethyl)phenylacetylchloride
  • (r)-(-)-à-methoxy-à-(trifluoromethyl)phenylacetyl chloride
  • (R)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride 99% (99%ee)
  • (r)-(-)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (R)-(fi)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (r)-(-)-a-methoxy-a-(trifluoromethyl) phenylacetyl chloride
  • (R)-(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 99%
  • (R)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride (99%ee)
  • (R)-(-)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetyl chloride, 98+%
  • (+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
  • (+)-MTPA-CL
  • (+)-MOSHER'S ACID CHLORIDE
  • MOSHER'S ACID CHLORIDE
  • (+)-MOSHER'S CHLORIDE
  • (S)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
  • (S)-(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE
  • (S)-(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
  • (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
  • (S)-(+)-MTPA-CL
  • (S)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYL ACETYL CHLORIDE
  • (R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid chloride
  • (R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride (ca. 18% in Dichloromethane, ca. 1.0mol/L)[for Determination of the optical purity of Alcohols and Amines]
  • (R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
  • (-)-α-Methoxy-α-(trifluoromethyl)phenylacetylChloride[forDeterminationoftheopticalpurityofAlcoholsandAmines]&gt
  • (R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride, 99%, n20D:1.4680 - 1.4700
  • Benzeneacetyl chloride, α-methoxy-α-(trifluoromethyl)-, (αR)-
  • (R)-(-)-a-Methoxy-a-trifluoromethylphenylacetyl chloride (ca. 18% in Dichloromethane, ca. 1.0mol/L)
  • (R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride
  • (-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride