(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE

Product Name: (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
CAS No.: 20445-33-4
Chemical Name: (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
Synonyms: (+)-MTPA-CL;R(-)-MTPA-CL;(S)-(+)-MTPA-CL;(2S)-2-Methoxy-2-;(+)-MOSHER'S CHLORIDE;(S)-(+)-MTPA-Chloride;(S)-(+)-Acid chloride;MOSHER'S ACID CHLORIDE;(+)-MOSHER'S ACID CHLORIDE;(S)-(+)-Mosher'sacidchloride
CBNumber: CB3170768
Molecular Formula: C10H8ClF3O2
Formula Weight: 252.62
MOL File: 20445-33-4.mol

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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Property

Boiling point:: 213-214 °C(lit.)
alpha: D24 +129.0± 0.2° (c = 5.17 in CCl4)
Density: 1.35 g/mL at 25 °C(lit.)
refractive index: n20/D 1.47(lit.)
Flash point:: 194 °F
storage temp.: -20°C
form: Liquid
Specific Gravity: 1.353
color: Clear colorless to light yellow
optical activity: [α]20/D +137±2°, c = 6.4% in carbon tetrachloride
Water Solubility: Slightly miscible with water.
Sensitive: Moisture Sensitive
Merck: 14,6280
BRN: 3591564
CAS DataBase Reference: 20445-33-4(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 34-43
Safety Statements: 26-36/37/39-45-27
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
F: 10-21
Hazard Note: Corrosive/Freeze
HazardClass: 8
PackingGroup: II
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 65365
Product name: (S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride
Purity: for chiral derivatization, LiChropur?, ≥99.0%
Packaging: 100mg
Price: $166
Updated: 2024/03/01

Sigma-Aldrich

Product number: 65365
Product name: (S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride
Purity: for chiral derivatization, LiChropur?, ≥99.0%
Packaging: 500mg
Price: $641
Updated: 2024/03/01

Sigma-Aldrich

Product number: 369675
Product name: (S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride
Purity: 99%
Packaging: 50mg
Price: $70.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 369675
Product name: (S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride
Purity: 99%
Packaging: 250mg
Price: $168
Updated: 2024/03/01

TCI Chemical

Product number: M1103
Product name: (S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
Purity: >98.0%(GC)
Packaging: 100mg
Price: $67
Updated: 2024/03/01

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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

(S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is used in the preparation of natural products and pheromones. It is also employed as a derivatization enantiomeric purity reagent used for the determination of enantiomeric purity of alcohol and amines by gas chromatography.

Uses

Used in the synthesis of natural products and pheromones.

Uses

Resolution of enantiomers primarily of alcohols and amines.

General Description

(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride is commonly used as a derivatizing agent in Mosher ester analysis and Mosher amide analysis, which are NMR-based methods for determining the absolute configuration of the chiral carbon center in secondary alcohols and amines, respectively.

Purification Methods

The most likely impurity is the free acid due to hydrolysis and should be checked by IR. If free from acid, then distil, taking care to keep moisture out of the apparatus. Otherwise add SOCl2 and reflux for 5hours and distil it. Note that shorter reflux times result in a higher boiling fraction (b 130-155o/1mm) which has been identified as the anhydride. [Dale et al. J Org Chem 34 2543 1969, for enantiomeric purity see Dale & Mosher J Am Chem Soc 97 512 1973.]

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Suppliers

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View Lastest Price from (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 20445-33-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-07-28

Hebei Guanlang Biotechnology Co., Ltd.

Product: (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 20445-33-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2023-03-24

Zhuozhou Wenxi import and Export Co., Ltd

Product: (S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride 99% 20445-33-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

20445-33-4, (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDERelated Search:

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 1-Pentanol Phenylacetyl chloride 3,3,3-TRIFLUOROPROPIONYL CHLORIDE (R)-2-CHLORO-1-PHENYLETHANOL 3-CHLORO-1,1,1-TRIFLUOROPROPANE (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE,(+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 4-FLUORO-3-(TRIFLUOROMETHYL)ANISOLE 1-CHLORO-2-METHYL-2-PROPANOL Methoxyacetyl chloride 1-PHENYL-2,2,2-TRIFLUOROETHANOL (+/-)-2-CHLORO-1-PHENYLETHANOL 1-CHLORO-3-FLUOROISOPROPANOL (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID Acetyl chloride

(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE

(S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%

(S)-(+)-MTPA-Cl, Moshers acid chloride

(S)-(+)-^a-Methoxy-^a-(trifluoromethyl)phenylacetyl chloride, 98+%

(S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride,99%

(R)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE

(R)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE

R(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID CHLORIDE

(R)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE

(R)-(-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYL ACETYL CHLORIDE

(R)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE

(+)-MOSHER'S ACID CHLORIDE

(S)-(+)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetyl chloride, 98+%

(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]

(S)-(+)-α-Methoxy-α-(trifluoromethyl)benzeneacetylchloride (+)-MTPA-Cl

(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride,(S)-(+)-MTPA-Cl, Mosher’s acid chloride

(2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99% (99%ee)

(S)-(+)-MTPACl, (S)-(+)-Mosher's acid chloride, (2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropionyl chloride

(S)-(+)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetyl chloride, 99% 1GR

(+)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetyl Chloride (ca. 18% in DichloroMethane, ca. 1.0Mol/L) [for DeterMination of the optical purity of Alcohols and AMines]

(+)-Mosher's Acid Chloride (+)-MTPA-Cl

(S)-3,3,3-Trifluoro-2-Methoxy-2-phenylpropanoyl chloride

(+)-α-Methoxy-α-(trifluoroMethyl)phenylacetyl Chloride [for DeterMination of the optical purity of Alcohols and AMines]

(+)-α-Methoxy-α-(trifluoroMethyl)phenylacetyl Chloride (ca. 18% in DichloroMethane, ca. 1.0Mol/L) [for DeterMination of the optical purity of Alcohols and AMines]

(2S)-2-Methoxy-2-

Benzeneacetyl chloride, α-Methoxy-α-(trifluoroMethyl)-, (S)-

Hydratropoyl chloride, β,β,β-trifluoro-α-Methoxy-, (+)- (8CI)

(2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99%

(S)-3,3,3-Trifluoro-2-methoxy-2-phenylpropionyl chloride

S-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid chloride

MOSHER'S ACID CHLORIDE

(+)-MOSHER'S CHLORIDE

(+)-MTPA-CL

R(-)-MTPA-CL

(S)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYL ACETYL CHLORIDE

(S)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE

(S)-(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE

(S)-(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE

(S)-(+)-MTPA-CL

(S)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)-PH ENYLACETYL CHLORIDE, 99%(98% EE/GLC)

(R)-(+)-Methoxy-trifluoromethylphenylacetyl chloride

(S)-(+)-Mosher'sacidchloride

(S)-(+)-MTPA-Chloride

(S)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetylchloride(ee)

(s)-(+)-à-methoxy-à-(trifluoromethyl)phenylacetyl chloride

(S)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride 99% (99%ee)

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 99%

(S)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride (99%ee)

(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetylChloride[forDeterminationoftheopticalpurityofAlcoholsandAmines]

(s)-(+)-alphaMethoxy-alpha(three fluoroMethyl)phenyl acetyl chloride

(2S)-2-Methoxy-2-trifluoromethylphenylacetyl chloride

(S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]

(S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride (ca. 18% in Dichloromethane, ca. 1.0mol/L) [for Determination of the optical purity of Alcohols and Amines]

(S)-2-Methoxy-2-(trifluoromethyl)phenylacetyl chloride

(2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoylchloride99%

(S)-(+)-α-Methoxy-α-(trifluoromethyl)benzeneacetylchloride

(S)-(+)-Acid chloride