ChemicalBook > CAS DataBase List > (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid

(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid

Product Name
(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid
CAS No.
20445-31-2
Chemical Name
(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid
Synonyms
Mosher;(R)-3,3,3-Trifluoro-2-Methoxy-2-phenylpropanoic acid;(+)-MTPA;(R)-(+)-MPTA;MOSHERS ACID;AgeSin? MTPA;Mosher’s acid;(+)-MOSHER'S ACID;(R)-(+)-Mosher acid;[Optical Resolving]
CBNumber
CB7461358
Molecular Formula
C10H9F3O3
Formula Weight
234.17
MOL File
20445-31-2.mol
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(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Property

Melting point:
46-49 °C(lit.)
Boiling point:
105-107 °C1 mm Hg(lit.)
alpha 
D25 +68.5 ± 1.3° (c = 1.49 in CH3OH)
Density 
1.344 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.473(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Soluble in methanol (50 mg/ 1 ml).
form 
Crystalline Low Melting Solid
pka
1.47±0.10(Predicted)
Specific Gravity
1.344
color 
White
optical activity
[α]20/D +73±1°, c = 2% in methanol
Sensitive 
Hygroscopic
Merck 
14,6280
BRN 
2215440
CAS DataBase Reference
20445-31-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
3-10
Hazard Note 
Irritant/Keep Cold
HazardClass 
IRRITANT, HYGROSCOPIC, KEEP COLD
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
155268
Product name
(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid
Purity
99%
Packaging
1g
Price
$292
Updated
2024/03/01
Sigma-Aldrich
Product number
155268
Product name
(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid
Purity
99%
Packaging
5g
Price
$532
Updated
2024/03/01
TCI Chemical
Product number
M0831
Product name
(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$197
Updated
2024/03/01
TCI Chemical
Product number
M0831
Product name
(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$747
Updated
2024/03/01
Alfa Aesar
Product number
B22968
Product name
(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid, 99%
Packaging
0.1g
Price
$43.65
Updated
2024/03/01
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(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

white crystalline low melting solid

Uses

(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR.

Uses

Mosher′s acid chloride is used as a dervatization agent for β-arylethylamines, enantiomeric alcohols, and enantiomeric amines. It is also a reagent used for the determination of enantiomeric purity and absolute configuration of alcohols and amines by NMR.

General Description

Mosher′s acid chloride is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.

Purification Methods

A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.]

(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Suppliers

Americas 1 Belgium 3 China 81 Europe 1 France 2 Germany 6 India 5 Japan 5 Switzerland 1 The Netherlands 2 United Kingdom 12 United States 33 Global 152
Shanghai Yichang Chemical Co., Ltd.
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View Lastest Price from (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid 99% 20445-31-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

20445-31-2, (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acidRelated Search:

4-Methoxyphenylacetic acid α-Lipoic Acid Ethyl 2-(Chlorosulfonyl)acetate Citric acid 4-(Trifluoromethoxy)aniline (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID (R)-(-)-alpha-Methoxyphenylacetic acid (Trifluoromethoxy)benzene Folic acid 3-(Trifluoromethoxy)bromobenzene 4-Methylphenylacetic acid Ascoric Acid 3,3,3-Trifluoropropanal 2-PHENYLPROPIONIC ACID 2-(TRIFLUOROMETHYL)-2-HYDROXYPROPIONIC ACID (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID 2-Fluoroethanol Lactic acid

  • (R)-(+)-MTPA,(R)-(+)-Mosher'sacid
  • (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid, 99%(e.e.>99.5%)
  • (+)--Methoxy--(trifluoromethyl)phenylaceticacid(Moshersacid)
  • (r)-(+)-à-methoxy-à-(trifluoromethyl)phenylacetic acid
  • (R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid 99% (99%ee)
  • (R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid (99%ee)
  • (R)-(+)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetic acid, 99%
  • (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
  • (2R)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid 99%
  • (R)-3,3,3-Trifluoro-2-Methoxy-2-phenylpropanoic acid
  • (R)-(+)-MTPA, (R)-(+)-Mosher's acid, (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
  • (R)-(+)-Mosher acid
  • (R)-3,3,3-Trifluoro-2-phenyl-2-methoxypropionic acid
  • [R,(+)]-3,3,3-Trifluoro-2-methoxy-2-phenylpropionic acid
  • [R,(+)]-α-Trifluoromethyl-α-methoxyphenylacetic acid
  • [R,(+)]-β,β,β-Trifluoro-α-methoxyhydratropic acid
  • (R)-(+)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetic Acid&nbsp
  • [Optical Resolving]
  • (R)-(+)-α-Methoxy-α-(trifluoroMethyl)phenylacetic Acid [Optical Resolving]
  • (R)-(+)-2-METHOXY-2-(TRIFLUOROMETHYL)PHENYLACETIC ACID
  • (R)-(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID
  • (R)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETIC ACID
  • (R)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETIC ACID
  • (R)-(+)-MPTA
  • (R)-(+)-MOSHER'S ACID
  • (+)-MOSHER'S ACID
  • MOSHERS ACID
  • (+)-MTPA
  • (+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID
  • (+)-A-METHOXY-A-TRIFLUOROMETHYLPHENYLACETIC ACID
  • (R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid
  • (R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylaceticacid(ee)
  • (R)-(+)-α-Methoxy-α-(trifluoroMethyl)phenylacetic acid, ee: 99.5%
  • (R)-(+)-alpha-Methoxy-alpha-trifluoroMethylphenylacetic acid 99%
  • Mosher
  • (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid
  • (R)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid, 99%(e.e.>99.5%)
  • (R)-(+)--Methoxy--(trifluoromethyl)phenylacetic acid, 98%, ee: 99.5%
  • (R)-(+)-α-Methoxy-α-(trifluoromethyl)phenylaceticAcid[OpticalResolving]&gt
  • Benzeneacetic acid, α-methoxy-α-(trifluoromethyl)-, (αR)-
  • Benzeneacetic acid, a-methoxy-a-(trifluoromethyl)-, (aR)-
  • (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic ac
  • (R)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
  • (R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid
  • (+)--methoxy--(trifluoromethyl)phenylacetic acid
  • (R)-2-Methoxy-2-phenyl-2-(trifluoromethyl)acetic Acid
  • AgeSin? MTPA
  • Mosher’s acid
  • 20445-31-2
  • C6H5COCH3CF3CO2H
  • C6H5COCH3CF3COOH
  • C5H5COCH3CF3CO2H
  • C10H9F3O3
  • e.e. / Absolute Conefiguration Determination (NMR)
  • Enantiomer Excess & Absolute Conefiguration Determination
  • Chiral Resolving Reagents
  • Chiral Resolution Reagents
  • Derivatization Reagents