(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid

Product Name: (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid
CAS No.: 20445-31-2
Chemical Name: (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid
Synonyms: Mosher;(R)-3,3,3-Trifluoro-2-Methoxy-2-phenylpropanoic acid;(+)-MTPA;(R)-(+)-MPTA;MOSHERS ACID;AgeSin? MTPA;Mosher’s acid;(+)-MOSHER'S ACID;(R)-(+)-Mosher acid;[Optical Resolving]
CBNumber: CB7461358
Molecular Formula: C10H9F3O3
Formula Weight: 234.17
MOL File: 20445-31-2.mol

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(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Property

Melting point:: 46-49 °C(lit.)
Boiling point:: 105-107 °C1 mm Hg(lit.)
alpha: D25 +68.5 ± 1.3° (c = 1.49 in CH3OH)
Density: 1.344 g/mL at 25 °C(lit.)
refractive index: n20/D 1.473(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Soluble in methanol (50 mg/ 1 ml).
pka: 1.47±0.10(Predicted)
form: Crystalline Low Melting Solid
color: White
Specific Gravity: 1.344
optical activity: [α]20/D +73±1°, c = 2% in methanol
Sensitive: Hygroscopic
Merck: 14,6280
BRN: 2215440
InChI: 1S/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15)/t9-/m1/s1
InChIKey: JJYKJUXBWFATTE-SECBINFHSA-N
SMILES: CO[C@@](C(O)=O)(c1ccccc1)C(F)(F)F
CAS DataBase Reference: 20445-31-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 3-10
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT, HYGROSCOPIC, KEEP COLD
HS Code: 29189900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 155268
Product name: (R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid
Purity: 99%
Packaging: 1g
Price: $301
Updated: 2025/07/31

Sigma-Aldrich

Product number: 155268
Product name: (R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid
Purity: 99%
Packaging: 5g
Price: $959
Updated: 2025/07/31

TCI Chemical

Product number: M0831
Product name: (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $197
Updated: 2025/07/31

TCI Chemical

Product number: M0831
Product name: (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $747
Updated: 2025/07/31

Sigma-Aldrich

Product number: 155268
Product name: (R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid
Purity: 99%
Packaging: 250mg
Price: $90.4
Updated: 2025/07/31

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(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

white crystalline low melting solid

Uses

(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR.

Uses

Mosher′s acid chloride is used as a dervatization agent for β-arylethylamines, enantiomeric alcohols, and enantiomeric amines. It is also a reagent used for the determination of enantiomeric purity and absolute configuration of alcohols and amines by NMR.

General Description

Mosher′s acid chloride is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.

Purification Methods

A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.]

(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Suppliers

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View Lastest Price from (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid 99% 20445-31-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

20445-31-2, (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acidRelated Search:

4-Methoxyphenylacetic acid Ethyl 2-(Chlorosulfonyl)acetate 4-(Trifluoromethoxy)aniline (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID (R)-(-)-alpha-Methoxyphenylacetic acid (Trifluoromethoxy)benzene Folic acid 3-(Trifluoromethoxy)bromobenzene 4-Methylphenylacetic acid Citric acid α-Lipoic Acid Ascoric Acid 3,3,3-Trifluoropropanal 2-PHENYLPROPIONIC ACID 2-(TRIFLUOROMETHYL)-2-HYDROXYPROPIONIC ACID (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID 2-Fluoroethanol Lactic acid

(R)-(+)-MTPA,(R)-(+)-Mosher'sacid

(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid, 99%(e.e.>99.5%)

(+)--Methoxy--(trifluoromethyl)phenylaceticacid(Moshersacid)

(r)-(+)-à-methoxy-à-(trifluoromethyl)phenylacetic acid

(R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid 99% (99%ee)

(R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid (99%ee)

(R)-(+)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetic acid, 99%

(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving]

(2R)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid 99%

(R)-3,3,3-Trifluoro-2-Methoxy-2-phenylpropanoic acid

(R)-(+)-MTPA, (R)-(+)-Mosher's acid, (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid

(R)-(+)-Mosher acid

(R)-3,3,3-Trifluoro-2-phenyl-2-methoxypropionic acid

[R,(+)]-3,3,3-Trifluoro-2-methoxy-2-phenylpropionic acid

[R,(+)]-α-Trifluoromethyl-α-methoxyphenylacetic acid

[R,(+)]-β,β,β-Trifluoro-α-methoxyhydratropic acid

(R)-(+)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetic Acid&nbsp

[Optical Resolving]

(R)-(+)-2-METHOXY-2-(TRIFLUOROMETHYL)PHENYLACETIC ACID

(R)-(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID

(R)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETIC ACID

(R)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETIC ACID

(R)-(+)-MPTA

(R)-(+)-MOSHER'S ACID

(+)-MOSHER'S ACID

MOSHERS ACID

(+)-MTPA

(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID

(+)-A-METHOXY-A-TRIFLUOROMETHYLPHENYLACETIC ACID

(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid

(R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylaceticacid(ee)

(R)-(+)-α-Methoxy-α-(trifluoroMethyl)phenylacetic acid, ee: 99.5%

(R)-(+)-alpha-Methoxy-alpha-trifluoroMethylphenylacetic acid 99%

Mosher

(2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid

(R)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid, 99%(e.e.>99.5%)

(R)-(+)--Methoxy--(trifluoromethyl)phenylacetic acid, 98%, ee: 99.5%

(R)-(+)-α-Methoxy-α-(trifluoromethyl)phenylaceticAcid[OpticalResolving]&gt

Benzeneacetic acid, α-methoxy-α-(trifluoromethyl)-, (αR)-

Benzeneacetic acid, a-methoxy-a-(trifluoromethyl)-, (aR)-

(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic ac

(R)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving]

(+)--methoxy--(trifluoromethyl)phenylacetic acid

(R)-2-Methoxy-2-phenyl-2-(trifluoromethyl)acetic Acid

AgeSin? MTPA

Mosher’s acid

(<i>R</i>)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid

(2R)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoic acid

(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid

20445-31-2

C6H5COCH3CF3CO2H

C6H5COCH3CF3COOH

C5H5COCH3CF3CO2H

C10H9F3O3

e.e. / Absolute Conefiguration Determination (NMR)

Enantiomer Excess & Absolute Conefiguration Determination

Chiral Resolving Reagents

Chiral Resolution Reagents