(R)-(-)-alpha-Methoxyphenylacetic acid

Product Name: (R)-(-)-alpha-Methoxyphenylacetic acid
CAS No.: 3966-32-3
Chemical Name: (R)-(-)-alpha-Methoxyphenylacetic acid
Synonyms: (R)-2-Methoxy-2-phenylacetic acid;(R)-(-)-α-Methoxyphenylacetic Acid;(R)-(-)-αBenzeneacetic acid, .a;O-METHYL-D-MANDELIC ACID;O-Methyl-(R)-mandelicacid;Acetic acid, methoxyphenyl;(-)-Methoxyphenylacetic acid;(1)-(Methoxy)phenylacetic acid;(methyloxy)(phenyl)acetic acid
CBNumber: CB2105770
Molecular Formula: C9H10O3
Formula Weight: 166.17
MOL File: 3966-32-3.mol

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(R)-(-)-alpha-Methoxyphenylacetic acid Property

Melting point:: 66-68 °C(lit.)
alpha: -160.4 º (C=1, MEOH)
Boiling point:: 164-166°C 18mm
Density: 1.1708 (rough estimate)
refractive index: -147 ° (C=0.5, EtOH)
Flash point:: 164-166°C/18mm
storage temp.: 2-8°C
solubility: Chloroform, Ethanol, Methanol
pka: 3.10±0.10(Predicted)
form: Fine Crystalline Powder or Needles
color: White
optical activity: [α]20/D -150±3°, c = 0.5% in ethanol
BRN: 3589257
InChI: 1S/C9H10O3/c1-12-8(9(10)11)7-5-3-2-4-6-7/h2-6,8H,1H3,(H,10,11)/t8-/m1/s1
InChIKey: DIWVBIXQCNRCFE-MRVPVSSYSA-N
SMILES: CO[C@@H](C(O)=O)c1ccccc1
CAS DataBase Reference: 3966-32-3(CAS DataBase Reference)
NIST Chemistry Reference: (R)-(-)-«alpha»-methoxyphenylacetic acid(3966-32-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29189900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 248967
Product name: (R)-(?)-α-Methoxyphenylacetic acid
Purity: 99%
Packaging: 1g
Price: $149.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 65209
Product name: (R)-(?)-α-Methoxyphenylacetic acid
Purity: for chiral derivatization, ≥99.0%
Packaging: 1g
Price: $310
Updated: 2022/05/15

TCI Chemical

Product number: M0830
Product name: (R)-(-)-alpha-Methoxyphenylacetic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: M0830
Product name: (R)-(-)-alpha-Methoxyphenylacetic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $123
Updated: 2025/07/31

TCI Chemical

Product number: M0830
Product name: (R)-(-)-alpha-Methoxyphenylacetic Acid
Purity: >98.0%(GC)(T)
Packaging: 100mg
Price: $16
Updated: 2025/07/31

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(R)-(-)-alpha-Methoxyphenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

white fine crystalline powder or needles

Uses

(R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors.

General Description

(R)-(?)-α-Methoxyphenylacetic acid is a chiral derivatizating agent, which is employed for derivatizing enantiomers into diastereoisomers.

Purification Methods

Purify the acids by recrystallising from *C6H6/pet ether (b 80-100o). [Neilson & Peters J Chem Soc 1519 1962, Weizmann et al. J Am Chem Soc 70 1153 1948, Pirie & Smith J Chem Soc 338 1932, NMR: Dale & Mosher J Am Chem Soc 9 5 512 1973, for resolution: Roy & Deslongchamps Can J Chem 63 651 1985, Trost et al. J Am Chem Soc 1 0 8 4974 1986.] The racemic mixture has m 72o, b 121-122o/0.4mm, 165o/18mm (from pet ether) [Braun et al. Chem Ber 6 3 2847 1930]. [Beilstein 10 IV 566.]

(R)-(-)-alpha-Methoxyphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-alpha-Methoxyphenylacetic acid Suppliers

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View Lastest Price from (R)-(-)-alpha-Methoxyphenylacetic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: (R)-(-)-alpha-Methoxyphenylacetic acid 3966-32-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-(-)-alpha-Methoxyphenylacetic acid 3966-32-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Career Henan Chemical Co

Product: (R)-(-)-alpha-Methoxyphenylacetic acid 3966-32-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: as request
Release date: 2018-12-24

3966-32-3, (R)-(-)-alpha-Methoxyphenylacetic acidRelated Search:

DL-Mandelic acid Folic acid 2-Hydroxyphenylacetic acid Glycine Ethyl 2-(Chlorosulfonyl)acetate 4-Hydroxyphenylacetic acid (2,5-Dimethoxyphenyl)acetic acid Citric acid α-Lipoic Acid Phenylacetic acid Pipoxolan Hcl PARGEVERINE HCL (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid (3,4-Dimethoxyphenyl)acetic acid (1-Methyl-4-piperidyl) 2,2-diphenyl-2-propoxy-acetate Dimenoxadol (-)-O-ACETYL-D-MANDELIC ACID Testosterone phenylacetate

(R)-(-)-METHOXYPHENYLACETIC ACID

O-METHYL-D-MANDELIC ACID

(R)-(-)-ALPHA-METHOXYPHENYLACETIC ACID

(R)-ALPHA-METHOXYPHENYLACETIC ACID

(R)-(-)-A-METHOXYPHENYLACETIC ACID

Benzeneacetic acid, alpha-methoxy-, (R)-

Acetic acid, methoxyphenyl- (8CI)

Benzeneacetic acid, .a

(<i>R</i>)-(-)-&alpha

R-MINUS-A-METHOXYPHENYL ACETIC ACID

O-Methyl-(R)-mandelicacid

(r)-(-)-à-methoxyphenylacetic acid

(R)-(-)-ALPHA-METHOXYPHENYLACETIC ACID 99%

(R)-(-)-ɑ-Methoxyphenylacetic acid, 99%

(2R)-2-Methoxy-2-phenylacetic acid

(R)-α-Methoxybenzeneacetic acid

(αR)-α-Methoxybenzeneacetic acid

[R,(-)]-α-Methoxybenzeneacetic acid

(R)-(-)-alpha-Methoxyphenylacetic acid,99%

(R)-()-α-Methoxyphenylacetic acid,O-Methyl-D-mandelic acid

(R)-(-)-alpha-Methoxyphenylacetic acid, 99% 1GR

(R)-2-Methoxy-2-phenylacetic acid

(1)-(Methoxy)phenylacetic acid

(methyloxy)(phenyl)acetic acid

2-methoxy-2-phenyl-ethanoic acid

Acetic acid, methoxyphenyl

(R)-(-)-α-MethoxyphenylaceticAcid&gt

Benzeneacetic acid, α-methoxy-, (αR)-

(R)-(-)-α-Methoxyphenylacetic Acid

?-(-)-alpha-Methoxyphenylacetic acid

(2S)-Methoxy(phenyl)acetic acid

(-)-Methoxyphenylacetic acid

(<i>R</i>)-(?)-α-Methoxyphenylacetic acid

(R)-(-)-α-Methoxyphenylacetic acid, CAS 3966-32-3

(R)-2-Methoxy-2-phenylacetic acid - [M90983]

3966-32-3

e.e. / Absolute Conefiguration Determination (NMR)

Enantiomer Excess & Absolute Conefiguration Determination

Chiral Building Blocks

Carboxylic Acids (Chiral)

Derivatization Reagents

Chiral Resolving Reagents

Analytical Chromatography Product Catalog

Chiral Derivatization

Chiral Resolution Reagents

Asymmetric Synthesis

Analytical Chemistry

Carboxylic Acids (Chiral)

Chiral Building Blocks

e.e. / Absolute Configuration Determination (NMR)

Enantiomer Excess & Absolute Configuration Determination

Synthetic Organic Chemistry