(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Property

Melting point:

46-49 °C(lit.)

Boiling point:

105-107 °C1 mm Hg(lit.)

alpha 

D25 +68.5 ± 1.3° (c = 1.49 in CH3OH)

Density 

1.344 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.473(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Soluble in methanol (50 mg/ 1 ml).

form 

Crystalline Low Melting Solid

pka

1.47±0.10(Predicted)

Specific Gravity

1.344

color 

White

optical activity

[α]20/D +73±1°, c = 2% in methanol

Sensitive 

Hygroscopic

Merck 

14,6280

BRN 

2215440

CAS DataBase Reference

20445-31-2(CAS DataBase Reference)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3-10

Hazard Note 

Irritant/Keep Cold

HazardClass 

IRRITANT, HYGROSCOPIC, KEEP COLD

HS Code 

29189900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

white crystalline low melting solid

Uses

(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR.

Uses

Mosher′s acid chloride is used as a dervatization agent for β-arylethylamines, enantiomeric alcohols, and enantiomeric amines. It is also a reagent used for the determination of enantiomeric purity and absolute configuration of alcohols and amines by NMR.

General Description

Mosher′s acid chloride is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.

Purification Methods

A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.]