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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE

Product Name
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
CAS No.
20445-33-4
Chemical Name
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
Synonyms
(+)-MTPA-CL;R(-)-MTPA-CL;(S)-(+)-MTPA-CL;(2S)-2-Methoxy-2-;(+)-MOSHER'S CHLORIDE;(S)-(+)-MTPA-Chloride;(S)-(+)-Acid chloride;MOSHER'S ACID CHLORIDE;(+)-MOSHER'S ACID CHLORIDE;(S)-(+)-Mosher'sacidchloride
CBNumber
CB3170768
Molecular Formula
C10H8ClF3O2
Formula Weight
252.62
MOL File
20445-33-4.mol
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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Property

Boiling point:
213-214 °C(lit.)
alpha 
D24 +129.0± 0.2° (c = 5.17 in CCl4)
Density 
1.35 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.47(lit.)
Flash point:
194 °F
storage temp. 
-20°C
form 
Liquid
Specific Gravity
1.353
color 
Clear colorless to light yellow
optical activity
[α]20/D +137±2°, c = 6.4% in carbon tetrachloride
Water Solubility 
Slightly miscible with water.
Sensitive 
Moisture Sensitive
Merck 
14,6280
BRN 
3591564
CAS DataBase Reference
20445-33-4(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34-43
Safety Statements 
26-36/37/39-45-27
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
F 
10-21
Hazard Note 
Corrosive/Freeze
HazardClass 
8
PackingGroup 
II
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
65365
Product name
(S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride
Purity
for chiral derivatization, LiChropur?, ≥99.0%
Packaging
100mg
Price
$166
Updated
2024/03/01
Sigma-Aldrich
Product number
65365
Product name
(S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride
Purity
for chiral derivatization, LiChropur?, ≥99.0%
Packaging
500mg
Price
$641
Updated
2024/03/01
Sigma-Aldrich
Product number
369675
Product name
(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride
Purity
99%
Packaging
50mg
Price
$70.1
Updated
2024/03/01
Sigma-Aldrich
Product number
369675
Product name
(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride
Purity
99%
Packaging
250mg
Price
$168
Updated
2024/03/01
TCI Chemical
Product number
M1103
Product name
(S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
Purity
>98.0%(GC)
Packaging
100mg
Price
$67
Updated
2024/03/01
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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

(S)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is used in the preparation of natural products and pheromones. It is also employed as a derivatization enantiomeric purity reagent used for the determination of enantiomeric purity of alcohol and amines by gas chromatography.

Uses

Used in the synthesis of natural products and pheromones.

Uses

Resolution of enantiomers primarily of alcohols and amines.

General Description

(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride is commonly used as a derivatizing agent in Mosher ester analysis and Mosher amide analysis, which are NMR-based methods for determining the absolute configuration of the chiral carbon center in secondary alcohols and amines, respectively.

Purification Methods

The most likely impurity is the free acid due to hydrolysis and should be checked by IR. If free from acid, then distil, taking care to keep moisture out of the apparatus. Otherwise add SOCl2 and reflux for 5hours and distil it. Note that shorter reflux times result in a higher boiling fraction (b 130-155o/1mm) which has been identified as the anhydride. [Dale et al. J Org Chem 34 2543 1969, for enantiomeric purity see Dale & Mosher J Am Chem Soc 97 512 1973.]

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE Suppliers

Americas 1 Belgium 2 China 75 Europe 1 France 2 Germany 3 India 5 Japan 2 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 11 United States 22 Global 129
Acros Organics
Tel
--
Fax
--
Email
info@acros.com
Country
Belgium
ProdList
6772
Advantage
81
Acros Organics (Part of Thermo Fisher Scientific )
Tel
--
Fax
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Email
fo@acros.com
Country
Belgium
ProdList
3824
Advantage
58
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View Lastest Price from (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 20445-33-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-19
Hebei Mojin Biotechnology Co., Ltd
Product
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 20445-33-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-07-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
(S)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride 99% 20445-33-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

20445-33-4, (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDERelated Search:

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 1-Pentanol Phenylacetyl chloride 3,3,3-TRIFLUOROPROPIONYL CHLORIDE (R)-2-CHLORO-1-PHENYLETHANOL 3-CHLORO-1,1,1-TRIFLUOROPROPANE (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE,(+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 4-FLUORO-3-(TRIFLUOROMETHYL)ANISOLE 1-CHLORO-2-METHYL-2-PROPANOL Methoxyacetyl chloride 1-PHENYL-2,2,2-TRIFLUOROETHANOL (+/-)-2-CHLORO-1-PHENYLETHANOL 1-CHLORO-3-FLUOROISOPROPANOL (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID Acetyl chloride

  • (+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
  • (S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%
  • (S)-(+)-MTPA-Cl, Moshers acid chloride
  • (S)-(+)-^a-Methoxy-^a-(trifluoromethyl)phenylacetyl chloride, 98+%
  • (S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride,99%
  • (R)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
  • (R)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE
  • R(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID CHLORIDE
  • (R)-(-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
  • (R)-(-)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYL ACETYL CHLORIDE
  • (R)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
  • (+)-MOSHER'S ACID CHLORIDE
  • (S)-(+)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetyl chloride, 98+%
  • (+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
  • (S)-(+)-α-Methoxy-α-(trifluoromethyl)benzeneacetylchloride (+)-MTPA-Cl
  • (S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride,(S)-(+)-MTPA-Cl, Mosher’s acid chloride
  • (2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99% (99%ee)
  • (S)-(+)-MTPACl, (S)-(+)-Mosher's acid chloride, (2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropionyl chloride
  • (S)-(+)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetyl chloride, 99% 1GR
  • (+)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetyl Chloride (ca. 18% in DichloroMethane, ca. 1.0Mol/L) [for DeterMination of the optical purity of Alcohols and AMines]
  • (+)-Mosher's Acid Chloride (+)-MTPA-Cl
  • (S)-3,3,3-Trifluoro-2-Methoxy-2-phenylpropanoyl chloride
  • (+)-α-Methoxy-α-(trifluoroMethyl)phenylacetyl Chloride [for DeterMination of the optical purity of Alcohols and AMines]
  • (+)-α-Methoxy-α-(trifluoroMethyl)phenylacetyl Chloride (ca. 18% in DichloroMethane, ca. 1.0Mol/L) [for DeterMination of the optical purity of Alcohols and AMines]
  • (2S)-2-Methoxy-2-
  • Benzeneacetyl chloride, α-Methoxy-α-(trifluoroMethyl)-, (S)-
  • Hydratropoyl chloride, β,β,β-trifluoro-α-Methoxy-, (+)- (8CI)
  • (2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoyl chloride 99%
  • (S)-3,3,3-Trifluoro-2-methoxy-2-phenylpropionyl chloride
  • S-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid chloride
  • MOSHER'S ACID CHLORIDE
  • (+)-MOSHER'S CHLORIDE
  • (+)-MTPA-CL
  • R(-)-MTPA-CL
  • (S)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYL ACETYL CHLORIDE
  • (S)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
  • (S)-(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE
  • (S)-(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
  • (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
  • (S)-(+)-MTPA-CL
  • (S)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)-PH ENYLACETYL CHLORIDE, 99%(98% EE/GLC)
  • (R)-(+)-Methoxy-trifluoromethylphenylacetyl chloride
  • (S)-(+)-Mosher'sacidchloride
  • (S)-(+)-MTPA-Chloride
  • (S)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetylchloride(ee)
  • (s)-(+)-à-methoxy-à-(trifluoromethyl)phenylacetyl chloride
  • (S)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride 99% (99%ee)
  • (S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE 99%
  • (S)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride (99%ee)
  • (+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetylChloride[forDeterminationoftheopticalpurityofAlcoholsandAmines]
  • (s)-(+)-alphaMethoxy-alpha(three fluoroMethyl)phenyl acetyl chloride
  • (2S)-2-Methoxy-2-trifluoromethylphenylacetyl chloride
  • (S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride [for Determination of the optical purity of Alcohols and Amines]
  • (S)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride (ca. 18% in Dichloromethane, ca. 1.0mol/L) [for Determination of the optical purity of Alcohols and Amines]
  • (S)-2-Methoxy-2-(trifluoromethyl)phenylacetyl chloride
  • (2S)-(+)-2-Methoxy-2-phenyl-3,3,3-trifluoropropanoylchloride99%
  • (S)-(+)-α-Methoxy-α-(trifluoromethyl)benzeneacetylchloride
  • (S)-(+)-Acid chloride