Pharmacological action Pharmacokinetics Usage Synthetic routes Contraindication Adverse reaction Precautions
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Econazole nitrate

Pharmacological action Pharmacokinetics Usage Synthetic routes Contraindication Adverse reaction Precautions
Product Name
Econazole nitrate
CAS No.
68797-31-9
Chemical Name
Econazole nitrate
Synonyms
ifenec;pevaryl;r14,827;palavale;ecostatin;Spectazole;epi-pevaryl;gyno-pevaryl;Econazolnitrat;Econazole Nitrat
CBNumber
CB6173104
Molecular Formula
C18H16Cl3N3O4
Formula Weight
444.7
MOL File
68797-31-9.mol
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Econazole nitrate Property

Density 
1.6311 (rough estimate)
refractive index 
1.6200 (estimate)
Water Solubility 
711.5mg/L(25 ºC)
InChIKey
DDXORDQKGIZAME-UHFFFAOYSA-N
CAS DataBase Reference
68797-31-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
NI4450000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000254
Product name
Econazole for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000254
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
E0050000
Product name
Econazole nitrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
e0050000
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
1231808
Product name
Econazole nitrate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
250mg
Price
$436
Updated
2024/03/01
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Econazole nitrate Chemical Properties,Usage,Production

Pharmacological action

Econazole nitrate, as a dechlorination derivative of miconazole, is an antifungal drug of piromidic. It has the antibacterial activity against candida, fonsecaea, coccidioides, histoplasma, sporotrichum and so on, and also has the anti-microbial activity against trichophyton,etc, but poor properties on aspergillus, sporothrix schenckii, some dermateaceae and mucor. It can disrupt the activity of cytochrome P450 to inhibit the biosynthesis of ergosterol, the main steroids of fungal cell membrane, damage the fungal cell membrane and change its permeability, so that the important intracellular matter leak out. It can inhibit the biosynthesis of triacylglycerol and phospholipid and the activity of oxidase and peroxidase to cause the accumulation of hydrogen peroxide in cells, which results in submicrostructure degeneration and necrocytosis. It can inhibit the transformation of candida albicans from spores to invasive hypha. It is applicable to tinea manuum, tinea pedis, tinea cruris, tinea corporis, tinea versicolor and cutaneous candidiasis.

Pharmacokinetics

After external use, most medicines enter into the epidermis, as well as the dermis. Only 1% can be absorbed into the blood stream. The amount of reabsorption in urine and faeces is less than 1% of the dosage.

Usage

It is applicable to tinea corporis, tinea manuum, tinea pedis, tinea cruris, tinea corporis, tinea versicolor and cutaneous candidiasis.

Synthetic routes

Use trichloroacetophenon as the starting material. After revivification and imidazole, add p-chlorobenzyl chloride to prepare the econazole through substitution. Finally econazole nitrate is obtained by salifying with nitric acid.

Fig. 1 shows the synthetic route of econazole nitrate

Contraindication

  • Do not use during the first trimester or menstruation.
  • Those allergic to imidazole medicament and other ingredients in this product are forbidden to use.
  • Primary bacterial infectious cutaneous condition and severe secondary bacterial infections (such as obvious pustules, exudation, pus, skin necrosis and ulcers).

Adverse reaction

  • Local irritation symptoms, such as pruritus and burning sensation;
  • Occasional erythema and blister, most of which are short and slight.

Precautions

  • Intended for external use only. Avoid contact with eyes.
  • To avoid relapses, patients with cutaneous candidiasis and various tinea diseases require at least a 2-week course of therapy, but at least a 4-week course for tinea pedis for prolonged periods.
  • Avoid the local tight covering of dressing in the treatment of candidiasis.
  • Do not be used in the place big area use for a long time.

Description

Econazole nitrate (EN) is a broad-spectrum antifungal medication used topically in the treatment of dermatomycoses due to a wide variety of fungi, such as athlete’s foot, jock itch, ringworm, and pityriasis. It is also used vaginally in the treatment of vaginal candidosis.

Uses

Antifungal.

brand name

Spectazole (Johnson & Johnson).

General Description

1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole (Spectazole) is a white crystalline nitricacid salt of econazole. It is only slightly soluble in waterand most organic solvents.Econazole is used as a 1% cream for the topical treatmentof local tinea infections and cutaneous candidiasis.

References

[1] P. Verma, B. Pharm, M. Pharm, K. Pathak, M. Pahrm, Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation, Nanomedicine: Nanotechnology, Biology, and Medicine, 2012, vol. 8, 489-496
[2] R. C. Heel, R. N. Brogden, T. M. Speight and G. S. Avery, Econazole: A Review of its Antifungal Activity and Therapeutic Efficacy, Drugs, 1978, vol. 16, 177-201
[3] http://www.webmd.com

Econazole nitrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Econazole nitrate Suppliers

Janssen Pharmaceutica NV
Tel
--
Fax
--
Email
JGCC_EMEA@its.jnj.com
Country
Belgium
ProdList
22
Advantage
58
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View Lastest Price from Econazole nitrate manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Econazole nitrate 68797-31-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2023-09-26
Baoji Guokang Bio-Technology Co., Ltd.
Product
Econazole nitrate 68797-31-9
Price
US $128.00/KG
Min. Order
25KG
Purity
98%
Supply Ability
1-20mt
Release date
2021-06-08
Wuhan Boyuan Import & Export Co., LTD
Product
Econazole Nitrate 68797-31-9
Price
US $30.00-20.00/kg
Min. Order
1kg
Purity
99.60%
Supply Ability
30tons
Release date
2023-04-23

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