GAMMA-METHYL-L-LEUCINE
- Product Name
- GAMMA-METHYL-L-LEUCINE
- CAS No.
- 57224-50-7
- Chemical Name
- GAMMA-METHYL-L-LEUCINE
- Synonyms
- H-LEU(ME)-OH;H-L-tBuAla-OH;H-L-NPTGLY-OH;H-ALA(TBU)-OH;β-tBu-L-Ala-OH;H-b-tBu-Ala-OH;BETA-TBU-ALANINE;4-METHYL-LEUCINE;NEOPENTYLGLYCINE;L-Nepentylglycine
- CBNumber
- CB6176701
- Molecular Formula
- C7H15NO2
- Formula Weight
- 145.2
- MOL File
- 57224-50-7.mol
GAMMA-METHYL-L-LEUCINE Property
- Melting point:
- 250 - 252°C
- Boiling point:
- 236.0±23.0℃ (760 Torr)
- Density
- 1.016±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 96.5±22.6℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Methanol (Slightly), Water (Sparingly)
- form
- Solid
- pka
- 2.56±0.23(Predicted)
- color
- White to Off-White
- optical activity
- Consistent with structure
- InChI
- InChI=1S/C7H15NO2/c1-7(2,3)4-5(8)6(9)10/h5H,4,8H2,1-3H3,(H,9,10)/t5-/m0/s1
- InChIKey
- LPBSHGLDBQBSPI-YFKPBYRVSA-N
- SMILES
- C(O)(=O)[C@@H](N)CC(C)(C)C
Safety
- WGK Germany
- 3
- F
- 10
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 73489
- Product name
- L-α-Neopentylglycine
- Purity
- ≥98.0%(TLC)
- Packaging
- 1g
- Price
- $382
- Updated
- 2025/07/31
- Product number
- 451068
- Product name
- Gamma-methyl-L-leucine
- Packaging
- 100mg
- Price
- $312
- Updated
- 2021/12/16
- Product number
- G195005
- Product name
- γ-methyl-L-leucine
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- AS85843
- Product name
- (2S)-2-Amino-4,4-dimethyl-pentanoic acid
- Purity
- 98+% ee
- Packaging
- 1g
- Price
- $203
- Updated
- 2021/12/16
- Product number
- FB48799
- Product name
- beta-tert-Butyl-L-alanine
- Packaging
- 1g
- Price
- $220
- Updated
- 2021/12/16
GAMMA-METHYL-L-LEUCINE Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
Gamma-methyl-L-leucine
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
34906-87-1
3060-50-2
119-61-9
57224-50-7
88319-43-1
GENERAL STEPS: To a 5 mL reaction vial equipped with a magnetic stirrer was added 3-cyclohexyl-2-oxopropanoic acid (1j) (0.0510 g, 0.30 mmol), 2,2-diphenylglycine (2) (0.0681 g, 0.30 mmol), chiral pyridoxamine 6 g (0.0195 g, 0.030 mmol) and MeOH-H2O (8:2) , v/v) (3.0 mL). The reaction mixture was stirred at 20 °C for 3 days. Upon completion of the reaction, the mixture was transferred to a 25 mL round-bottom flask and methanol was added until all solids were completely dissolved. Silica gel (0.50 g) was then added. The solvent was removed by reduced pressure distillation at 20 °C and the resulting residue was purified by silica gel column chromatography (eluent ratio EtOH/ethyl acetate/25-28% ammonia solution = 100:58:16) to afford compound 3j (0.0401 g, 78% yield, 52% ee) as a white solid. To determine the enantiomeric excess of 3b-k, compound 3j was first treated with thionyl chloride in methanol and subsequently converted to N-benzoylmethyl ester by reaction with benzoyl chloride and finally analyzed by HPLC. For the determination of enantiomeric excess of compound 3a, it was converted to methyl ester by treatment with CH2N2 in methanol followed by HPLC analysis.
References
[1] Tetrahedron Letters, 2016, vol. 57, # 41, p. 4612 - 4615
GAMMA-METHYL-L-LEUCINE Preparation Products And Raw materials
Raw materials
Preparation Products
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