4-HYDROXYISOLEUCINE
- Product Name
- 4-HYDROXYISOLEUCINE
- CAS No.
- 55399-93-4
- Chemical Name
- 4-HYDROXYISOLEUCINE
- Synonyms
- HIL;HYDROXYISOLEUCINE, 4-;4 -Hydroxyisoleucic acid;HYDROXYISOLEUCINE, 4-(FG);(4S)-4-Hydroxy-L-isoleucine;Hydroxyisoleucine 55399-93-4;TIANFU-CHEM 4-HYDROXYISOLEUCINE;4-HYDROXYISOLEUCINECAS:55399-93-4;[DISCONTINUED] Replaced by KIT-00008502-0HK;4-HYDROXYISOLEUCINE; 4-HYDROXY-L-ISOLEUCINE
- CBNumber
- CB5274835
- Molecular Formula
- C6H13NO3
- Formula Weight
- 147.17
- MOL File
- 55399-93-4.mol
4-HYDROXYISOLEUCINE Property
- Melting point:
- 223-224℃
- Boiling point:
- 331.6±32.0 °C(Predicted)
- Density
- 1.181±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 147℃
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 2.41±0.25(Predicted)
- color
- White to Off-White
- optical activity
- [α]/D +32.5±2.0°, c = 1 in H2O
- BRN
- 4128096
- InChI
- InChI=1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4-,5-/m0/s1
- InChIKey
- OSCCDBFHNMXNME-YUPRTTJUSA-N
- SMILES
- C(O)(=O)[C@@H](N)[C@@H](C)[C@H](C)O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 50118
- Product name
- (4S)-4-Hydroxy-L-isoleucine
- Purity
- from fenugreek seed, ≥98.0% (TLC)
- Packaging
- 50mg
- Price
- $527
- Updated
- 2024/03/01
- Product number
- 11812
- Product name
- 4-Hydroxyisoleucine
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 11812
- Product name
- 4-Hydroxyisoleucine
- Packaging
- 25mg
- Price
- $1169
- Updated
- 2024/03/01
- Product number
- 11812
- Product name
- 4-Hydroxyisoleucine
- Packaging
- 5mg
- Price
- $302
- Updated
- 2024/03/01
- Product number
- 11812
- Product name
- 4-Hydroxyisoleucine
- Packaging
- 10mg
- Price
- $535
- Updated
- 2024/03/01
4-HYDROXYISOLEUCINE Chemical Properties,Usage,Production
Description
4-Hydroxyisoleucine is an amino acid that has been found in fenugreek (T. foenum graecum) seeds and has antidiabetic activity. It increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas when used at a concentration of 200 μM. In vivo, 4-hydroxyisoleucine increases PI3K activity in muscle and liver in rats when administered at a dose of 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide and streptozotocin (STZ; ) when administered at 25 mg/kg. 4-Hydroxyisoleucine (50 mg/kg per day for four weeks) decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes.
Occurrence
4-hydroxyisoleucine has been extracted and purified from fenugreek seeds, which are known in traditional medicine for their antidiabetic properties.
Uses
(4S)-4-Hydroxy-L-isoleucine is 4S isomer of 4-Hydroxyisoleucine, which is used as a treatment for type II diabetes.
Definition
ChEBI: An L-isoleucine derivative that is L-isoleucine bearing a (4S)-hydroxy substituent.
Biological Activity
4-Hydroxyisoleucine increases glucose-induced insulin release, in the concentration range of 100 micromol/l to 1 mmol/l, through a direct effect on isolated islets of Langerhans from both rats and humans.
4-HYDROXYISOLEUCINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-HYDROXYISOLEUCINE Suppliers
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View Lastest Price from 4-HYDROXYISOLEUCINE manufacturers
- Product
- 4-HYDROXYISOLEUCINE 55399-93-4
- Price
- US $40.00-30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 30 tons
- Release date
- 2024-03-06
- Product
- 4-HYDROXYISOLEUCINE 55399-93-4
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 90%min
- Supply Ability
- 10KGS
- Release date
- 2021-06-05
- Product
- 4-hydroxyisoleucine 55399-93-4
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 97%
- Supply Ability
- 10 tons
- Release date
- 2023-03-16