ChemicalBook > CAS DataBase List > FR 122047 HYDROCHLORIDE

FR 122047 HYDROCHLORIDE

Product Name
FR 122047 HYDROCHLORIDE
CAS No.
130717-51-0
Chemical Name
FR 122047 HYDROCHLORIDE
Synonyms
FR 122047;FR122047HCl;FR 122047 HYDROCHLORIDE;COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem;5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine;5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole;(4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl;[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone;1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE
CBNumber
CB6178619
Molecular Formula
C23H26ClN3O3S
Formula Weight
459.99
MOL File
130717-51-0.mol
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FR 122047 HYDROCHLORIDE Property

storage temp. 
2-8°C
solubility 
methylene chloride: 50 mg/mL, slightly hazy, yellow
form 
powder
color 
faint yellow
Water Solubility 
Soluble to 10 mM in water
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F7553
Product name
FR 122047 hydrochloride
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$693
Updated
2024/03/01
Sigma-Aldrich
Product number
236005
Product name
COX-1 Inhibitor, FR122047
Packaging
5mg
Price
$259
Updated
2024/03/01
Cayman Chemical
Product number
10039
Product name
FR122047 (hydrochloride)
Packaging
5mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
10039
Product name
FR122047 (hydrochloride)
Packaging
50mg
Price
$606
Updated
2024/03/01
Cayman Chemical
Product number
10039
Product name
FR122047 (hydrochloride)
Packaging
1mg
Price
$32
Updated
2024/03/01
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FR 122047 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

FR122047 is a selective inhibitor of COX-1. The IC50 values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC50 of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

Uses

FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor.

Biological Activity

Selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.028 and 65 μ M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo .

storage

Desiccate at +4°C

FR 122047 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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FR 122047 HYDROCHLORIDE Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq:1580084073
Email
1580084073@qq.com
Country
China
ProdList
650
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd
Tel
15658004993
Email
1900830611@qq.com
Country
China
ProdList
965
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 15162312715
Email
sales@szzxbio.com
Country
China
ProdList
2988
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4988
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12005
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
32957
Advantage
60
Shanghai PI Chemicals Ltd.
Tel
--
Fax
--
Email
sales@pipharm.com
Country
China
ProdList
6344
Advantage
56

130717-51-0, FR 122047 HYDROCHLORIDERelated Search:


  • 4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE
  • 4,5-BIS(4-METHOXYPHENYL)-2-[(1-METHYLPIPERAZINE-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE
  • 1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE
  • 1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE
  • FR 122047
  • FR 122047 HYDROCHLORIDE
  • FR122047HCl
  • (4,5-Bis(4-Methoxyphenyl)thiazol-2-yl)(4-Methylpiperazin-1-yl)Methanone hydrochloride
  • COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem
  • [4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone
  • (4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl
  • Methanone, [4,5-bis(4-methoxyphenyl)-2-thiazolyl](4-methyl-1-piperazinyl)-, hydrochloride (1:1)
  • 5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole
  • 5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine
  • FR 122047 hydrochloride,Cyclooxygenase,FR 122047,FR122047,inhibit,Inhibitor,COX,FR-122047
  • 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride|||1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride
  • 130717-51-0
  • C23H25N3O3SHCl
  • A to C
  • Biochemicals and Reagents
  • BioChemical
  • Cyclooxygenase
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Prostanoid receptor and related