Coumarin 106
- Product Name
- Coumarin 106
- CAS No.
- 41175-45-5
- Chemical Name
- Coumarin 106
- Synonyms
- COUMARIN 478;COUMARIN 106;11-hexahydro-;Exciton Coumarin 478;Coumarin106,lasergrade;Coumarin 106Coumarin 478;Coumarin 106,pure,laser grade;COUMARIN 106, LASER GRADE, PURE;1h,5h-cyclopenta[3,4][1]benzopyrano[6,7,8-ij]quinolizin-12(9h)-one,2,3,6,7,10,;2,3,5,6,7,9,10,11-octahydrocyclopenta[4,5]pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-12(1H)-one
- CBNumber
- CB6178790
- Molecular Formula
- C18H19NO2
- Formula Weight
- 281.35
- MOL File
- 41175-45-5.mol
Coumarin 106 Property
- Melting point:
- 149 °C
- Boiling point:
- 538.4±50.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- solubility
- DMSO: Slightly soluble: 0.1-1 mg/ml
- pka
- 6.38±0.20(Predicted)
- form
- powder to crystal
- color
- Light orange to Yellow to Green
- λmax
- 375nm(Acetone)(lit.)
- EPA Substance Registry System
- 1H,5H-Cyclopenta[3,4][1]benzopyrano[6,7,8-ij]quinolizin-12(9H)-one, 2,3,6,7,10,11-hexahydro- (41175-45-5)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 37/39-26
- HS Code
- 29322985
N-Bromosuccinimide Price
- Product number
- C3043
- Product name
- Coumarin 478
- Purity
- >98.0%(HPLC)
- Packaging
- 200mg
- Price
- $184
- Updated
- 2025/07/31
- Product number
- C755558
- Product name
- Coumarin 478
- Packaging
- 2.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC150860
- Product name
- Coumarin106
- Packaging
- 100mg
- Price
- $67
- Updated
- 2021/12/16
- Product number
- FC150860
- Product name
- Coumarin106
- Packaging
- 250mg
- Price
- $132.5
- Updated
- 2021/12/16
- Product number
- FC150860
- Product name
- Coumarin106
- Packaging
- 500mg
- Price
- $230
- Updated
- 2021/12/16
Coumarin 106 Chemical Properties,Usage,Production
Description
Coumarin 478 is a vital chemical compound used in biomedicine mainly for its anticancer properties. It has demonstrated potential in inhibiting tumor growth and metastasis, making it a valuable drug in the treatment of various types of cancers. Coumarin 478 shows promising results in clinical trials and is actively being researched for its effectiveness against specific cancer types.
Chemical Properties
yellow powder and chunks
Uses
Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC50=4.97 and Ki=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC50=4.56)[1][2].
References
[1] Patil SK, et al. Determination of ground and excited state dipole moments of dipolar laser dyes by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:117-26. DOI:10.1016/j.saa.2013.12.031
[2] Fallarero A, et al. Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. Pharmacol Res. 2008 Sep-Oct;58(3-4):215-21. DOI:10.1016/j.phrs.2008.08.001
[3] G.A. REYNOLDS K. H D. New coumarin dyes with rigidized structure for flashlamp-pumped dye lasers[J]. Optics Communications, 1975, 13 3: Pages 222-225. DOI: 10.1016/0030-4018(75)90085-1
[4] EMMA ALEXANDER. Room temperature phosphorescence of coumarin 106 with direct triplet state excitation[J]. Dyes and Pigments, 2023, 217: Article 111389. DOI: 10.1016/j.dyepig.2023.111389
Coumarin 106 Preparation Products And Raw materials
Raw materials
Preparation Products
Coumarin 106 Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from Coumarin 106 manufacturers
- Product
- Coumarin 106 41175-45-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-07