Coumarin 106

Product Name: Coumarin 106
CAS No.: 41175-45-5
Chemical Name: Coumarin 106
Synonyms: COUMARIN 478;COUMARIN 106;11-hexahydro-;Exciton Coumarin 478;Coumarin106,lasergrade;Coumarin 106Coumarin 478;Coumarin 106,pure,laser grade;COUMARIN 106, LASER GRADE, PURE;1h,5h-cyclopenta[3,4][1]benzopyrano[6,7,8-ij]quinolizin-12(9h)-one,2,3,6,7,10,;2,3,5,6,7,9,10,11-octahydrocyclopenta[4,5]pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-12(1H)-one
CBNumber: CB6178790
Molecular Formula: C18H19NO2
Formula Weight: 281.35
MOL File: 41175-45-5.mol

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Coumarin 106 Property

Melting point:: 149 °C
Boiling point:: 538.4±50.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
solubility: DMSO: Slightly soluble: 0.1-1 mg/ml
pka: 6.38±0.20(Predicted)
form: powder to crystal
color: Light orange to Yellow to Green
λmax: 375nm(Acetone)(lit.)
EPA Substance Registry System: 1H,5H-Cyclopenta[3,4][1]benzopyrano[6,7,8-ij]quinolizin-12(9H)-one, 2,3,6,7,10,11-hexahydro- (41175-45-5)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 37/39-26
HS Code: 29322985

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3043
Product name: Coumarin 478
Purity: >98.0%(HPLC)
Packaging: 200mg
Price: $184
Updated: 2025/07/31

TRC

Product number: C755558
Product name: Coumarin 478
Packaging: 2.5mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC150860
Product name: Coumarin106
Packaging: 100mg
Price: $67
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC150860
Product name: Coumarin106
Packaging: 250mg
Price: $132.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC150860
Product name: Coumarin106
Packaging: 500mg
Price: $230
Updated: 2021/12/16

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Coumarin 106 Chemical Properties,Usage,Production

Description

Coumarin 478 is a vital chemical compound used in biomedicine mainly for its anticancer properties. It has demonstrated potential in inhibiting tumor growth and metastasis, making it a valuable drug in the treatment of various types of cancers. Coumarin 478 shows promising results in clinical trials and is actively being researched for its effectiveness against specific cancer types.

Chemical Properties

yellow powder and chunks

Uses

Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC50=4.97 and Ki=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC50=4.56)[1][2].

References

[1] Patil SK, et al. Determination of ground and excited state dipole moments of dipolar laser dyes by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:117-26. DOI:10.1016/j.saa.2013.12.031
[2] Fallarero A, et al. Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. Pharmacol Res. 2008 Sep-Oct;58(3-4):215-21. DOI:10.1016/j.phrs.2008.08.001
[3] G.A. REYNOLDS K. H D. New coumarin dyes with rigidized structure for flashlamp-pumped dye lasers[J]. Optics Communications, 1975, 13 3: Pages 222-225. DOI: 10.1016/0030-4018(75)90085-1
[4] EMMA ALEXANDER. Room temperature phosphorescence of coumarin 106 with direct triplet state excitation[J]. Dyes and Pigments, 2023, 217: Article 111389. DOI: 10.1016/j.dyepig.2023.111389

Coumarin 106 Preparation Products And Raw materials

Raw materials

Preparation Products

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Coumarin 106 Suppliers

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View Lastest Price from Coumarin 106 manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Coumarin 106 41175-45-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-07

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41175-45-5