N2,9-Diacetylguanine

Product Name: N2,9-Diacetylguanine
CAS No.: 3056-33-5
Chemical Name: N2,9-Diacetylguanine
Synonyms: DIACETYL GUANINE;2,9-DIACETYLGUANINE;N2,9-DIACETYLGUANINE;2,9-DAG;9-diacetylguanine;N,9-DIACETYLGUANINE;2,9-DIACETATEGUANINE;2,9-Guanine Diacetate;N2,N9-Diacetylguanine;Acyclovir EP Impurity L
CBNumber: CB6183086
Molecular Formula: C9H9N5O3
Formula Weight: 235.2
MOL File: 3056-33-5.mol

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N2,9-Diacetylguanine Property

Melting point:: 285 °C(lit.)
Density: 1.67±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated)
form: Solid
pka: 8.37±0.20(Predicted)
color: White to Light Beige
InChI: InChI=1S/C9H9N5O3/c1-4(15)11-9-12-7-6(8(17)13-9)10-3-14(7)5(2)16/h3H,1-2H3,(H2,11,12,13,15,17)
InChIKey: GILZZWCROUGLIS-UHFFFAOYSA-N
SMILES: C(NC1NC(=O)C2=C(N=1)N(C(C)=O)C=N2)(=O)C
CAS DataBase Reference: 3056-33-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3604
Product name: N2,9-Diacetylguanine
Purity: >95.0%(T)
Packaging: 25g
Price: $92
Updated: 2024/03/01

Alfa Aesar

Product number: B22709
Product name: N(2),9-Diacetylguanine, 99%
Packaging: 5g
Price: $51.65
Updated: 2024/03/01

TRC

Product number: D335000
Product name: N2,9-Diacetylguanine
Packaging: 50g
Price: $200
Updated: 2021/12/16

Usbiological

Product number: D3441-50
Product name: N 2,9-Diacetylguanine
Packaging: 10g
Price: $319
Updated: 2021/12/16

TRC

Product number: D335000
Product name: N2,9-Diacetylguanine
Packaging: 100g
Price: $400
Updated: 2021/12/16

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N2,9-Diacetylguanine Chemical Properties,Usage,Production

Description

N2,9-Diacetylguanine is a purine compound that can be prepared by acetylation of guanine with acetic anhydride. It can be used in many fields such as organic synthesis, biological research and pharmaceutical manufacturing. N2,9-Diacetylguanine can be prepared into 2-amino-6-halogenated purine under the action of two-step PEG-2000 phase transfer catalyst and TPPB phase transfer catalyst, and further through the corresponding CuX-catalyzed diazotization reaction, new 2-halogenated purine compounds can be efficiently synthesized^[2]. In addition, it can also be used as an intermediate for the antiviral drugs Ganciclovir and Aciclovir.

Chemical Properties

white or brownish crystalline powder

Uses

N2,9-Diacetylguanine (Acicclovir EP Impurity L) is used to synthesize acyclic analogues of deoxyguanosine.

Application

The alkylation of N2,N9- diacetylguanine (DAG) with 2-oxa-1, 4-butane-dioldiacetate to give N2-acetyl-9-{2-acetoxyethoxymethyl}- guanine (N9 isomer) and/or N2-acetyl-7-{2-acetoxyethoxymethyl}- guanine (N7 isomer) in exceptionally high regioselectivity[1].

References

[1] Dharmendra Singh, Ashok Kumar, Mukesh J. Wani. “A Simple Solution to the Age Old Problem of Regioselective Functionalization of Guanine: First Practical Synthesis of Acyclic N9- and/or N7-Guanine Nucleosides Starting from N2,N9-Diacetylguanine.” The Journal of Organic Chemistry 64 13 (1999): 4665–4668.
[2] Y. HU. Synthesis of Some Biologically Active Halogenopurines[J]. Journal of the Korean Chemical Society-Daehan Hwahak Hoe Jee, 2010. DOI:10.5012/JKCS.2010.54.4.429.

N2,9-Diacetylguanine Preparation Products And Raw materials

Raw materials

Guanosine

Preparation Products

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View Lastest Price from N2,9-Diacetylguanine manufacturers

Xinxiang Aurora Biotechnology Co.,Ltd.

Product: N(2),9-Diacetylguanine 3056-33-5
Price: US $0.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20Ton
Release date: 2024-10-29

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N,9-Diacetylguanine 3056-33-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 500kgs/month
Release date: 2021-10-28

Hebei Weibang Biotechnology Co., Ltd

Product: N,9-Diacetylguanine 3056-33-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-09-06

3056-33-5, N2,9-DiacetylguanineRelated Search:

Acetamide 6-Methoxyguanine Acetyl coenzyme A sodium salt 9-[(2-Acetoxyethoxy)methyl]-N2-acetylguanine Acetylacetone Acetylferrocene 6-Thioguanine N2-Isobutyryl-2'-deoxyguanosine 5'-O-Dimethoxytrityl-N-isobutyryl-deoxyguanosine DMT-dG(ib) Phosphoramidite 9-carboxymethoxymethylguanine Acyclovir IMpurity C 9-(2'-ACETOXYETHOXYMETHYL)-GUANINE Guanine 9-(2-Hydroxyethyl)guanine Aciclovir IMp. D (EP) IBU-DMT-DEOXYGUANOSINE SUCCINIC ACID 8-HYDROXY-N2-ISOBUTRYL-2'-DEOXYGUANOSINE

2-ACETYLAMINO-6-OXO-9-ACETYLPURINE

2,9-DAG

2,9-DIACETATEGUANINE

2,9-DIACETYLGUANINE

9-diacetylguanine

(9-acetyl-6,9-dihydro-6-oxo-1h-purin-2-yl)acetamide

DIACETYL GUANINE

N2,9-DIACETYLGUANINE

2,9-Guanine Diacetate

N-(9-acetyl-6,9-dihydro-6-oxo-1H-purin-2-yl)acetamide

N,9-DIACETYLGUANINE

2,9-DIACETYLGUANINE(DIACETYLGUANINE)

Acyclovir impurity 9/Acyclovir EP Impurity L/N-(9-acetyl-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide

Acyclovir (Aciclovir) EP Impurity L

N-(1-acetyl-4-oxo-5H-imidazo[4,5-c]pyridin-6-yl)acetamide

Acyclovir Impurity 4（Acyclovir EP Impurity L）

N-(9-acetyl-6-oxo-3H-purin-2-yl)acetamide

Acyclovir EP Impurity L

N2,9-DIACETYLGUANINE (DIACETYL GUANINE)

N2,9-DIACETYLGUANINE [DIACETYL GUANINE]ACYCLOVIR

2-Acetamido-9-acetyl-6-oxopurine

N(sup 2),9-diacetylguanine

2-(Acetylamino)-9-acetyl-1,9-dihydro-6H-purine-6-one

2-(Acetylamino)-9-acetyl-9H-purine-6(1H)-one

N-(9-Acetyl-6-oxo-6,9-dihydro-1H-purin-2-yl)acetaMide

N<sup>2</sup>,9-Diacetylguanine

N2,N9-Diacetylguanine

Aciclovir EP Impurity L

N2,9-Diacetylguanine&gt

Acetamide, N-(9-acetyl-6,9-dihydro-6-oxo-1H-purin-2-yl)-

N,9-Diacetylguanine USP/EP/BP

Acicclovir EP Impurity L

N(2),9-Diacetylguanine, 99%,

L.?N-(9-acetyl-6-oxo-6,9-dihydro-1h-purin-2-yl)acetamide(N2,9-diacetylguanine),

3056-33-5

3056-33-6

C9H9N5O3

C9H9O3N5

Purines

Heterocyclic Building Blocks

Building Blocks

Heterocyclic Building Blocks

Purines

Biochemistry

Nucleobases and their analogs

Nucleosides, Nucleotides & Related Reagents

Bases & Related Reagents

Nucleotides

Nucleotides and Nucleosides

Purine

Pyridines, Pyrimidines, Purines and Pteredines