3-AMINOPHTHALIC ACID HYDROCHLORIDE
- Product Name
- 3-AMINOPHTHALIC ACID HYDROCHLORIDE
- CAS No.
- 6946-22-1
- Chemical Name
- 3-AMINOPHTHALIC ACID HYDROCHLORIDE
- Synonyms
- 3-Aminophthalic acid HCL;3-amino-hydrochloride;Pomalidomide Impurity 5;3-AMINOPHTHALIC ACID HYDR;Pomalidomide Impurity A HCl;Pomalidomide Impurity 22 HCl;3-AminophthalicacidHClhydrate;3-aminophthalic acid chloride;3-Aminophthalsurehydrochlorid;3-AMINOPHTHALIC ACID HYDROCHLORIDE
- CBNumber
- CB6183187
- Molecular Formula
- C8H8ClNO4
- Formula Weight
- 217.61
- MOL File
- 6946-22-1.mol
3-AMINOPHTHALIC ACID HYDROCHLORIDE Property
- Melting point:
- 182 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- form
- Crystalline Powder
- color
- Off-white to yellow-beige
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C8H7NO4.ClH/c9-5-3-1-2-4(7(10)11)6(5)8(12)13;/h1-3H,9H2,(H,10,11)(H,12,13);1H
- InChIKey
- ZBZAVEORKXFUQB-UHFFFAOYSA-N
- SMILES
- C1(C(=O)O)C(N)=CC=CC=1C(=O)O.Cl
- CAS DataBase Reference
- 6946-22-1(CAS DataBase Reference)
- EPA Substance Registry System
- 1,2-Benzenedicarboxylic acid, 3-amino-, hydrochloride (6946-22-1)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 24/25
- TSCA
- Yes
- HS Code
- 29242998
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A627715
- Product name
- 3-AminophthalicAcidHydrochloride
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FA29862
- Product name
- 3-Aminophthalic acid hydrochloride
- Packaging
- 5G
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FA29862
- Product name
- 3-Aminophthalic acid hydrochloride
- Packaging
- 10g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FA29862
- Product name
- 3-Aminophthalic acid hydrochloride
- Packaging
- 25g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 4657-5-38
- Product name
- 3-Aminophthalic acid hydrochloride
- Packaging
- 25g
- Price
- $224
- Updated
- 2021/12/16
3-AMINOPHTHALIC ACID HYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
off-white to yellow-beige crystalline powder
Uses
3-Aminophthalic Acid Hydrochloride is a reactant used in the preparation of local anesthetics.
Synthesis
603-11-2
6946-22-1
The general procedure for the synthesis of 3-aminophthalic acid hydrochloride from 3-nitrophthalic acid was as follows: an ethanol solution (600 mL) of 3-nitrophthalic acid (100 g) and 10% Pd/C catalyst (3.2 g) was added to an autoclave. A hydrogen pressure of 4.0 kg was applied at 20-25 °C and the reaction was carried out for 3.0 hours. Upon completion of the reaction, the reaction mixture was cooled to 20 °C and filtered through a Hyflo bed. The filtrate was concentrated by distillation under reduced pressure and acetone was added to the residue. The mixture was cooled to 10 °C and concentrated hydrochloric acid was added slowly with continuous stirring. After removing the solvent under reduced pressure, acetonitrile was added. The mixture was again cooled to 10°C and the precipitated solid was filtered. Finally, the product was dried under vacuum at 45-50 °C for 6 h to give 3-aminophthalic acid hydrochloride (65.0 g).
References
[1] Patent: US5103057, 1992, A
[2] Patent: EP434145, 1991, A2
[3] Patent: WO2017/33116, 2017, A1. Location in patent: Paragraph 00114; 00132
[4] Patent: CN106986783, 2017, A. Location in patent: Paragraph 0008
3-AMINOPHTHALIC ACID HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-AMINOPHTHALIC ACID HYDROCHLORIDE Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
- 60
View Lastest Price from 3-AMINOPHTHALIC ACID HYDROCHLORIDE manufacturers
- Product
- 3-Aminophthalic acid hydrochloride 6946-22-1
- Price
- US $171.00/kg
- Min. Order
- 1kg
- Purity
- 98.0%min
- Supply Ability
- 12tons/month
- Release date
- 2024-12-30
- Product
- 3-Aminophthalic Acid Hydrochloride Dihydrate 6946-22-1
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21
- Product
- 3-AMINOPHTHALIC ACID HYDROCHLORIDE 6946-22-1
- Price
- US $1.00-7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-26