4-BROMO-3-NITROBENZONITRILE
Uses- Product Name
- 4-BROMO-3-NITROBENZONITRILE
- CAS No.
- 89642-49-9
- Chemical Name
- 4-BROMO-3-NITROBENZONITRILE
- Synonyms
- 3-nitro-4-broMobenzonitrile;2-Bromo-5-cyanonitrobenzene;4-BROMO-3-NITROBENZONITRILE;Benzonitrile, 4-bromo-3-nitro-;4-Bromo-3-nitrobenzonitrile 97%;4-BROMO-3-NITROBENZONITRILE ISO 9001：2015 REACH
- CBNumber
- CB6184836
- Molecular Formula
- C7H3BrN2O2
- Formula Weight
- 227.01
- MOL File
- 89642-49-9.mol
4-BROMO-3-NITROBENZONITRILE Property
- Melting point:
- 116-120 °C
- Boiling point:
- 269℃
- Density
- 1.81
- Flash point:
- 116℃
- storage temp.
- 2-8°C
- form
- powder to crystal
- color
- White to Light yellow to Light orange
Safety
- WGK Germany
- 3
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 701246
- Product name
- 4-Bromo-3-nitrobenzonitrile
- Purity
- 97%
- Packaging
- 25g
- Price
- $127.5
- Updated
- 2025/07/31
- Product number
- 701246
- Product name
- 4-Bromo-3-nitrobenzonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $204
- Updated
- 2025/07/31
- Product number
- B4708
- Product name
- 4-Bromo-3-nitrobenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $55
- Updated
- 2025/07/31
- Product number
- B4708
- Product name
- 4-Bromo-3-nitrobenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $167
- Updated
- 2025/07/31
- Product number
- B697965
- Product name
- 4-Bromo-3-nitrobenzonitrile
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
4-BROMO-3-NITROBENZONITRILE Chemical Properties,Usage,Production
Uses
4-Bromo-3-nitrobenzenenitrile is an important intermediate in organic synthesis. Because it has two second-class substituents, nitro and cyano, on its aromatic ring, as well as a bromine that can participate in the reaction, these two compounds have broad application prospects in the field of organic synthesis.
Synthesis
623-00-7
89642-49-9
General procedure for the synthesis of 4-bromo-3-nitrobenzonitrile from 4-bromobenzonitrile: To a concentrated solution of 4-bromobenzonitrile (4.0 g, 22 mmol) was added concentrated sulfuric acid (10 mL) and nitric acid (6 mL) slowly and dropwise at 0 °C. The reaction mixture was kept stirred at 0 °C for 30 min, then warmed up to room temperature and continued stirring for 2.5 h. The reaction was carried out at room temperature. Upon completion of the reaction, the mixture was slowly poured into ice water. The resulting white precipitate was collected by filtration and washed with water until the washings were neutral. The resulting solid was recrystallized twice by ethanol/water solvent mixture (1:1, 20 mL) to finally obtain 4-bromo-3-nitrobenzonitrile as a white crystalline solid (2.8 g, 56% yield). The product was identified by 1H NMR (300 MHz, DMSO-d6): δ8.54 (s, 1H), 8.06 (d, J = 8.4 Hz, 1H), 7.99 (d, J = 8.4 Hz, 1H); 13C NMR (75 MHz, DMSO-d6) δ150.4,137.4,136.6,129.6,119.6, 117.0,112.6; HPLC retention time 1.96 min (10-100% CH3CN, gradient 5 min); ESI-MS m/z 227.1 ([MH]+).
References
[1] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 0673
[2] Recueil des Travaux Chimiques des Pays-Bas, 1922, vol. 41, p. 36
[3] Recueil des Travaux Chimiques des Pays-Bas, 1922, vol. 41, p. 106,107
[4] Chemische Berichte, 1916, vol. 49, p. 2224
[5] Chemische Berichte, 1890, vol. 23, p. 3442
4-BROMO-3-NITROBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMO-3-NITROBENZONITRILE manufacturers
- Product
- 4-BROMO-3-NITROBENZONITRILE 89642-49-9
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26
- Product
- 4-Bromo-3-nitrobenzonitrile 89642-49-9
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2020-01-10
- Product
- 4-BROMO-3-NITROBENZONITRILE 89642-49-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-09-03