EXENDIN (5-39)

Product Name: EXENDIN (5-39)
CAS No.: 196109-27-0
Chemical Name: EXENDIN (5-39)
Synonyms: EXENDIN (5-39);Exendin4(5-39);Exendin 4 (5-39)amide;THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
CBNumber: CB6186087
Formula Weight: 0
MOL File: Mol file

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EXENDIN (5-39) Property

form: Solid
color: White to off-white
Sequence: Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PEP0011754
Product name: EXENDIN (5-39)
Purity: 95.00%
Packaging: 5MG
Price: $497.82
Updated: 2021/12/16

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EXENDIN (5-39) Chemical Properties,Usage,Production

Uses

Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats[1].

in vivo

Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG^[1].

Animal Model:	Wistar rats (3 weeks old and 18 days pregnant)^[1]
Dosage:	0.3 μg
Administration:	Intracerebroventricular injection; 0.3 μg; once daily; 1-week
Result:	Inhibited GLT-1 protein levels and inhibited long-term depression in rats.

References

[1] Kazuma Kobayashi, et al. Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus. Brain Res. 2013 Apr 10;1505:1-10. DOI:10.1016/j.brainres.2013.01.012

EXENDIN (5-39) Preparation Products And Raw materials

Raw materials

Preparation Products

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EXENDIN (5-39) Suppliers

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196109-27-0, EXENDIN (5-39)Related Search:

EXENDIN (5-39)

THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2

Exendin 4 (5-39)amide

Exendin4(5-39)

196109-27-0