5-CYANO-2-FLUOROBENZENEBORONIC ACID
- Product Name
- 5-CYANO-2-FLUOROBENZENEBORONIC ACID
- CAS No.
- 468718-30-1
- Chemical Name
- 5-CYANO-2-FLUOROBENZENEBORONIC ACID
- Synonyms
- 5-Cyano-2-fL;AKOS BRN-0641;CAS:468718-30-1;3-Borono-4-fluorobenzonitrile;5-CYANO-2-FLUOROPHENYLBORONIC ACID;5-CYANO-2-FLUOROBENZENEBORONIC ACID;5-Cyano-2-fluorobenzeneboronicacid98%;5-Cyano-2-fluorobenzeneboronic acid 98%;Boronic acid, B-(5-cyano-2-fluorophenyl)-;Boronic acid, (5-cyano-2-fluorophenyl)- (9CI)
- CBNumber
- CB6186517
- Molecular Formula
- C7H5BFNO2
- Formula Weight
- 164.93
- MOL File
- 468718-30-1.mol
5-CYANO-2-FLUOROBENZENEBORONIC ACID Property
- Melting point:
- 300
- Boiling point:
- 351.3±52.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Crystalline Powder
- pka
- 6.97±0.58(Predicted)
- color
- White
- CAS DataBase Reference
- 468718-30-1(CAS DataBase Reference)
Safety
- Risk Statements
- 20/21/22-36/37/38-22
- Safety Statements
- 26-36/37/39-22
- RIDADR
- 3439
- Hazard Note
- Harmful/Keep Cold
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C3227
- Product name
- 5-Cyano-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $136
- Updated
- 2025/07/31
- Product number
- C3227
- Product name
- 5-Cyano-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $411
- Updated
- 2025/07/31
- Product number
- C987583
- Product name
- 5-Cyano-2-fluorophenylboronicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C987583
- Product name
- 5-Cyano-2-fluorophenylboronicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC76261
- Product name
- 5-Cyano-2-fluorophenylboronic acid
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
5-CYANO-2-FLUOROBENZENEBORONIC ACID Chemical Properties,Usage,Production
Uses
suzuki reaction
Synthesis
121-43-7
1194-02-1
468718-30-1
468717-46-6
Example 163 Synthesis of 3-(2-dimethylaminomethyl-cyclopropyl)-1H-indazole-5-carbonitrile Procedure: n-BuLi (1.9 M, 26.3 mL, 50 mmol) was slowly added dropwise under nitrogen protection to a solution of diisopropylamine (7.71 mL, 55 mmol) in anhydrous THF (100 mL), keeping the reaction temperature at 0 °C. After 10 min. the reaction system was cooled to -78 °C. Subsequently, a solution of 4-fluorobenzonitrile (6.06 g, 50 mmol) in anhydrous THF (20 mL) was added dropwise at a rate that maintained the internal temperature at -78 °C. After stirring at this temperature for 1 hour, trimethyl borate (8.41 mL, 75 mmol) was added dropwise, also at a rate maintaining an internal temperature of -78 °C. The reaction mixture was stirred at -78 °C and gradually warmed to room temperature for 16 hours. Upon completion of the reaction, the system was cooled to 10 °C and 25 mL of 6N HCl was added. stirring was continued at room temperature for 4 h. The reaction mixture was then partitioned between water and ethyl acetate. The organic layer was washed three times with 100 mL of 2N NaOH. The aqueous layers were combined and adjusted to pH 6 with 6N HCl. The white solid formed was extracted through three times with 100mL ethyl acetate. The organic layers were combined, dried with sodium sulfate, concentrated and dried under high vacuum to give 2-fluoro-5-cyanophenylboronic acid (5.74 g, 70% yield). The product was confirmed by 1H NMR (500 MHz, acetone-d6): δ 8.08 (1H, dd, J = 2.14,5.5 Hz), 7.90 (1H, m), 7.31 (1H, t, J = 8.85 Hz). Elemental analysis (C7H5BFNO2) Calculated values: C, 50.97; H, 3.05; N, 8.49. Measured values: C, 51.19; H, 3.19; N, 8.26.
References
[1] Patent: US2003/73849, 2003, A1
5-CYANO-2-FLUOROBENZENEBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CYANO-2-FLUOROBENZENEBORONIC ACID manufacturers
- Product
- 5-CYANO-2-FLUOROBENZENEBORONIC ACID 468718-30-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg; 5kg; 100kg
- Release date
- 2019-07-03