3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER

Product Name: 3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER
CAS No.: 775351-57-0
Chemical Name: 3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER
Synonyms: Bm369;3-Cyano-4-fluorobenzeneboronic acid pinacol ester;3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER;5-Cyano-2-fluorobenzeneboronic acid pinacol ester, 96%;3-Cyano-4-fluorobenzeneboronic acid pinacol ester, 96%;3-Cyano-4-fluorophenylboronic acid, pinacol ester 95+%;2-fluoro-5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitri;2-fluoro-5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile;2-(3-Cyano-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
CBNumber: CB2842754
Molecular Formula: C13H15BFNO2
Formula Weight: 247.07
MOL File: 775351-57-0.mol

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3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER Property

Melting point:: 75-76℃
Boiling point:: 334.5±32.0 °C(Predicted)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Solid
color: White to Almost white

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Safety

RIDADR: UN3439
HazardClass: 6.1
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BML00105
Product name: 3-Cyano-4-fluorophenylboronic acid pinacol ester
Purity: Aldrich
Packaging: 1g
Price: $73.1
Updated: 2025/07/31

TCI Chemical

Product number: F1253
Product name: 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
Packaging: 1G
Price: $52
Updated: 2025/07/31

TCI Chemical

Product number: F1253
Product name: 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
Packaging: 5G
Price: $158
Updated: 2025/07/31

TRC

Product number: C987608
Product name: 3-Cyano-4-fluorophenylboronic acid pinacol ester
Packaging: 1g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: AMTB1214
Product name: 3-Cyano-4-fluorobenzeneboronicacidpinacolester
Packaging: 1g
Price: $25
Updated: 2021/12/16

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3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER Chemical Properties,Usage,Production

Synthesis

179897-89-3

73183-34-3

775351-57-0

2-Fluoro-5-bromobenzonitrile (1000.00 mg, 5.00 mmol, 1.00 eq.) and pinacol ester of bisboronic acid (1396.61 mg, 5.50 mmol, 1.10 eq.) were added to potassium acetate (1472.07 mg, 15.00 mmol, 3.00 eq.) in a dioxane (10 mL) and DMF (1 mL) ) in a solvent mixture of dioxane (10 mL) and DMF (1 mL) for degassing. Subsequently, [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride 1:1 complex with dichloromethane (366.85 mg, 0.50 mmol, 0.10 eq.) was added. The reaction mixture was placed in a sealed vial and the reaction was heated at 100 °C overnight. After completion of the reaction, it was cooled to room temperature and filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to remove the solvent, and the resulting crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane, gradient 0 to 5%) to afford the target product 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (1.0 g, 81% yield).

References

[1] Patent: US2016/376283, 2016, A1. Location in patent: Paragraph 0504; 0505; 0506
[2] Patent: WO2011/25799, 2011, A1. Location in patent: Page/Page column 50
[3] Organic Letters, 2004, vol. 6, # 19, p. 3265 - 3268

3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER Suppliers

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View Lastest Price from 3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER manufacturers

Career Henan Chemical Co

Product: 3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER 775351-57-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg; 2kg；10kg; 100kg
Release date: 2019-08-30

775351-57-0, 3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTERRelated Search:

3-Cyanophenylboronic acid 3-Cyano-4-fluorobenzeneboronic acid 2-FLUORO-5-METHYLPHENYLBORONIC ACID 5-CYANO-2-FLUOROBENZENEBORONIC ACID 4-Fluorobenzonitrile 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)FLUOROBENZENE 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE 3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER 4-Fluoro-3-methylphenylboronic acid 2-FLUOROPHENYLBORONIC ACID, PINACOL ESTER

3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER

Bm369

2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

2-fluoro-5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

3-Cyano-4-fluorobenzeneboronic acid pinacol ester, 96%

5-Cyano-2-fluorobenzeneboronic acid pinacol ester, 96%

Benzonitrile, 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-fluoro-5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitri

3-Cyano-4-fluorophenylboronic acid, pinacol ester 95+%

2-(3-Cyano-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

3-Cyano-4-fluorobenzeneboronic acid pinacol ester

775351-57-0

75351-57-0

Aryl

Organoborons