3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE

Product Name: 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE
CAS No.: 214360-46-0
Chemical Name: 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE
Synonyms: 3-(tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile;3-(4,4,5,5-tetraMethy;3-cyanphenylboronic acid pinacol ester;3-CYANOPHENYLBORONIC ACID, PINACOL ESTER;3-Cyanobenzeneboronic acid, pinacol ester;(3-Cyanophenyl)boronic acid pinalol ester;1,1,2,2-Tetramethyldimethylene (3-cyanophenyl)boronate;2-(3-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE;3-(4,4,5,5-tetraMethyl-1,3,2-dioxoborolan-2-yl)-benzonitrile
CBNumber: CB9215973
Molecular Formula: C13H16BNO2
Formula Weight: 229.08
MOL File: 214360-46-0.mol

More

Less

3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE Property

Melting point:: 78-82 °C (lit.)
Boiling point:: 341.0±25.0 °C(Predicted)
Density: 1.06±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Solid
color: White
InChI: InChI=1S/C13H16BNO2/c1-12(2)13(3,4)17-14(16-12)11-7-5-6-10(8-11)9-15/h5-8H,1-4H3
InChIKey: FIGQEPXOSAFKTA-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=CC(B2OC(C)(C)C(C)(C)O2)=C1
CAS DataBase Reference: 214360-46-0(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29319090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 578401
Product name: 3-Cyanophenylboronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $58.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 578401
Product name: 3-Cyanophenylboronic acid pinacol ester
Purity: 97%
Packaging: 5g
Price: $249
Updated: 2023/01/07

Usbiological

Product number: 269090
Product name: 3-Cyanophenylboronic acid pinacol ester
Packaging: 1g
Price: $352
Updated: 2021/12/16

TRC

Product number: C989753
Product name: 3-Cyanophenylboronic acid pinacol ester
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: C989753
Product name: 3-Cyanophenylboronic acid pinacol ester
Packaging: 250mg
Price: $55
Updated: 2021/12/16

More

Less

3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

3-Cyanophenylboronic acid pinacol ester can be used as a reactant to synthesize:

3-Cyano aryl/ heteroaryl derivatives by forming a C?C bond via palladium-catalyzed Suzuki-Miyaura reaction.
3-(Phenylamino)benzonitrile by copper-catalyzed Chan-Evans-Lam amination reaction.
3-(Trifluoromethyl)benzonitrile using potassium (trifluoromethyl)trimethoxyborate.

Synthesis

2237-30-1

73183-34-3

214360-46-0

To a solution of 3-aminobenzonitrile (0.5 g, 4.23 mmol) in acetonitrile (30 mL) was added tert-butyl nitrite (0.7 mL, 6.34 mmol) and pinacol ester of bis(boronic acid) (1.29 g, 5.076 mmol) sequentially at 0 °C. The reaction mixture was warmed to 80 °C and stirred continuously for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (combiflash system) with the eluent being a 4% ethyl acetate/hexane solvent mixture, resulting in pinacol ester of 3-cyanobenzeneboronic acid (0.35 g, 99.8% yield). The molecular weight of the product was confirmed by LCMS analysis: m/z 294 ([M+H]+).

References

[1] Patent: WO2015/105779, 2015, A1. Location in patent: Page/Page column 17; 18
[2] Patent: US2016/333005, 2016, A1. Location in patent: Paragraph 0064-0065
[3] Journal of Organic Chemistry, 2013, vol. 78, # 5, p. 1923 - 1933
[4] Angewandte Chemie - International Edition, 2010, vol. 49, # 10, p. 1846 - 1849

3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE Suppliers

China 108 France 1 Germany 4 India 4 Japan 2 Switzerland 1 The Netherlands 1 United Kingdom 12 United States 30 Global 163

Hangzhou SuGuan Chemical Technology Co., Ltd.

Tel: 15958048562
Fax: -
Email: 2032153781@qq.com
Country: China
ProdList: 463
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

More

Less

View Lastest Price from 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 214360-46-0
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-03

Shanghai Daken Advanced Materials Co.,Ltd

Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 214360-46-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG /month
Release date: 2021-11-17

Career Henan Chemical Co

Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 214360-46-0
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 100kg
Release date: 2019-07-10

214360-46-0, 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILERelated Search:

3-Cyanophenylboronic acid 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE,4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE 97% 2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE 2-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile 3-CYANO-4-FLUOROPHENYLBORONIC ACID, PINACOL ESTER 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE 1,3-DICYANO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-BENZENE 5-Cyano-2-methoxyphenylboronic acid pinacol ester

3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE

3-CYANOPHENYLBORONIC ACID, PINACOL ESTER

3-Cyanobenzeneboronic acid, pinacol ester

3-(4,4,5,5-tetraMethyl-1,3,2-dioxoborolan-2-yl)-benzonitrile

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrilele

3-(tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

3-cyanphenylboronic acid pinacol ester

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, 2-(3-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

(3-Cyanophenyl)boronic acid pinacol ester 1,1,2,2-Tetramethyldimethylene (3-cyanophenyl)boronate

2-(3-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

3-(4,4,5,5-tetraMethy

1,1,2,2-Tetramethyldimethylene (3-cyanophenyl)boronate

(3-cyanophenyl)-(3-hydroxy-2,3-dimethylbutan-2-yl)oxyborinic acid

(3-Cyanophenyl)boronic acid pinalol ester

Benzonitrile, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

214360-46-0

Aryl

Boronic Acids and Derivatives

Boronate Esters

Organometallic Reagents