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1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-

Product Name
1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-
CAS No.
143141-23-5
Chemical Name
1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-
Synonyms
N-Benzenesulfonyl-7-azaindole;1-(Phenylsulfonyl)-7-azaindole;1-(Phenylsulphonyl)-7-azaindole;1-(Benzenesulfonyl)pyrrolo[2,3-b]pyridine;1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-
CBNumber
CB61871759
Molecular Formula
C13H10N2O2S
Formula Weight
258.3
MOL File
143141-23-5.mol
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1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)- Property

Melting point:
130-132 °C
Boiling point:
465.8±37.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Store at 0-8 °C
pka
1.38±0.30(Predicted)
Appearance
brown solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CVT00058
Product name
N-Benzenesulfonyl-7-azaindole
Packaging
1g
Price
$332
Updated
2023/01/07
TRC
Product number
B535205
Product name
1-(Benzenesulfonyl)pyrrolo[2,3-b]pyridine
Packaging
50mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
8H69-1-1Z
Product name
1-(Phenylsulfonyl)-7-azaindole
Packaging
1g
Price
$30
Updated
2021/12/16
Matrix Scientific
Product number
068814
Product name
1-(Benzenesulfonyl)pyrrolo[2,3-b]pyridine
Purity
>95%
Packaging
1g
Price
$357
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0155587
Product name
1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE
Purity
95.00%
Packaging
500MG
Price
$806.19
Updated
2021/12/16
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1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)- Chemical Properties,Usage,Production

Synthesis

271-63-6

98-09-9

143141-23-5

4.2.4 Synthesis of 1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (5) In a dry and nitrogen purged round bottom flask, 1H-pyrrolo[2,3-b]pyridine (1.01 g, 8.58 mmol), tetrabutylammonium bromide (81 mg, 0.25 mmol), finely ground sodium hydroxide (1.02 g, 25.41 mmol) and dichloromethane (20 mL) were added. The mixture was cooled to 0 °C in an ice bath and stirred, followed by the slow dropwise addition of benzenesulfonyl chloride (1.35 mL, 10.59 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously at this temperature for 1 hour. Upon completion of the reaction, water (20 mL) was added for hydrolysis and then extracted twice with dichloromethane. The organic layers were combined, washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 2.38 g of a beige solid. The crude product was purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate=7:3) to give 2.17 g of white solid target product in 99% yield. 1H NMR (300 MHz, CDCl3) δ (ppm): 8.45 (dd, J = 1.5, 4.8 Hz, 1H), 8.20 (d, J = 7.5 Hz, 2H), 7.86 (dd, J = 1.5, 7.8 Hz, 1H), 7.73 (d, J = 4.0 Hz, 1H), 7.57 (dd, J = 7.4 Hz, 1H ), 7.52-7.47 (m, 2H), 7.19 (dd, J = 4.8, 7.8 Hz, 1H), 6.61 (d, J = 4.0 Hz, 1H). 13C NMR (75 MHz, CDCl3) δ (ppm): 144.7 (2C), 138.3, 134.1, 129.9, 129.1 (2C), 128.0 (2C), 126.5, 123.0, 119.0, 105.5.

References

[1] European Journal of Medicinal Chemistry, 2016, vol. 108, p. 701 - 719
[2] Patent: WO2016/114816, 2016, A1. Location in patent: Paragraph 0290
[3] Organic Letters, 2015, vol. 17, # 19, p. 4710 - 4713
[4] Tetrahedron, 1997, vol. 53, # 10, p. 3637 - 3648
[5] Patent: WO2006/50076, 2006, A1. Location in patent: Page/Page column 61

1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)- Suppliers

China 58 Germany 1 India 1 United States 8 Global 68
Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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United States
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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SpringPharma Tech Co.,Ltd
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Shanghai Sunway Pharmaceutical Technology Co., Ltd
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NovoChemy Ltd.
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66113011 17798518460
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(1)02557626880
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cfzhang@aikonchem.com
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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9ding chemical ( Shanghai) Limited
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4009209199
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Nanjing ShengSai Chemical Co., Ltd.
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View Lastest Price from 1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)- manufacturers

Honest Joy Holdings Limited
Product
1-(Phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 143141-23-5
Price
US $0.00/KG
Min. Order
1KG
Purity
97.8%
Supply Ability
100 tons
Release date
2022-01-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)- 143141-23-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)- 143141-23-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

143141-23-5, 1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-Related Search:

1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)- 7-Azaindole 4-BROMO-2-IODO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]- 4-CHLORO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE 4-BROMO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE 1-BENZENESULFONYL-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE 1-[(4-FLUOROPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE 1-[(2,4-DICHLOROPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE 1-BENZENESULFONYL-5-FLUORO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE 1-BENZENESULFONYL-5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE 1-[(4-BROMOPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE MORPHOLINO[1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDIN-2-YL]METHANONE N-(4-METHOXYPHENYL)-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXAMIDE 1-[(4-CHLOROPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE N-(4-CHLORO-2-METHYLPHENYL)-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXAMIDE ETHYL 2-(1-[(4-METHOXYPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-2-OXOACETATE [1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDIN-2-YL](2-THIENYL)METHANOL

  • 1-(Phenylsulphonyl)-7-azaindole
  • N-Benzenesulfonyl-7-azaindole
  • 1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine
  • 1-(Benzenesulfonyl)pyrrolo[2,3-b]pyridine
  • 1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-
  • 1-(Phenylsulfonyl)-7-azaindole
  • 143141-23-5
  • Heterocycle-Pyridine series