ChemicalBook > CAS DataBase List > 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-

1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-

Product Name: 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-
CAS No.: 348640-02-8
Chemical Name: 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-
Synonyms: N-Tosyl-7-azaindole;1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridine;1-[(4-methylphenyl)sulphonyl]-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-
CBNumber: CB61871764
Molecular Formula: C14H12N2O2S
Formula Weight: 272.32
MOL File: 348640-02-8.mol

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1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]- Property

Melting point:: 132-133℃
storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 020020
Product name: 1-(Toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine
Purity: 98+%
Packaging: 250mg
Price: $44
Updated: 2021/12/16

Matrix Scientific

Product number: 020020
Product name: 1-(Toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine
Purity: 98+%
Packaging: 500mg
Price: $73
Updated: 2021/12/16

AK Scientific

Product number: 4254AB
Product name: 1-Tosyl-1H-pyrrolo[2,3-b]pyridine
Packaging: 250mg
Price: $88
Updated: 2021/12/16

AK Scientific

Product number: 4254AB
Product name: 1-Tosyl-1H-pyrrolo[2,3-b]pyridine
Packaging: 1g
Price: $109
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0082943
Product name: 1-(TOLUENE-4-SULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE
Purity: 95.00%
Packaging: 250MG
Price: $858.17
Updated: 2021/12/16

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1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]- Chemical Properties,Usage,Production

Synthesis

271-63-6

98-59-9

348640-02-8

1. To a stirred solution of 7-azaindole (6.0 g, 50.0 mmol, 1.0 eq.) in THF (20 mL) at 0 °C was slowly added NaH (60% dispersion, 2.2 g, 66.0 mmol, 1.3 eq.). 2. The reaction mixture was gradually warmed to room temperature and stirred continuously for 30 minutes. 3. After the reaction mixture was cooled to 0 °C again, p-toluenesulfonyl chloride (TsCl, 11.6 g, 60.0 mmol, 1.2 eq.) was added. 4. The reaction mixture was stirred at room temperature overnight. 5. Upon completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate (EtOAc). 6. The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. 7. Purification of the crude product by column chromatography (eluent: hexane/ethyl acetate gradient) afforded 1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (Intermediate 1a) as a white solid (12.8 g, 93% yield, 100% UPLC purity).

References

[1] Patent: US2018/179199, 2018, A1. Location in patent: Paragraph 0445-0446
[2] Angewandte Chemie - International Edition, 2016, vol. 55, # 39, p. 11859 - 11862
[3] Angew. Chem., 2016, vol. 128, p. 12038 - 12041,4
[4] Chemistry Letters, 2011, vol. 40, # 6, p. 555 - 557
[5] Patent: US2009/318455, 2009, A1. Location in patent: Page/Page column 98-99

1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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348640-02-8, 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-Related Search:

1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]- METHYL 1-TOSYL-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE 4-CHLORO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE METHYL 6-(TRIFLUOROMETHYL)-1-TOSYL-1H-PYRROLO-[2,3-B]PYRIDINE-3-CARBOXYLATE 4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-1-[(4-methylphenyl)sulfonyl]- 1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid METHYL 5-CHLORO 1-TOSYL-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE 1-TOSYL-1H-PYRROLO[2,3-B]PYRIDINE-4-BORONIC ACID PINACOL ESTER

1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-

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