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A-740003

Product Name
A-740003
CAS No.
861393-28-4
Chemical Name
A-740003
Synonyms
CS-451;A-740003;A-740003, >=99%;A 740003; A740003;A740003 - CAS 861393-28-4 - Calbiochem;P2XRs,P2X Receptor,inhibit,A-740003,A740003,Inhibitor;(E)-N-(1-((Cyanamido(quinolin-5-ylamino)methylene)amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyp;N-(1-(3-Cyano-2-(quinolin-5-yl)guanidino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide;N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
CBNumber
CB61871931
Molecular Formula
C26H30N6O3
Formula Weight
474.55
MOL File
861393-28-4.mol
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A-740003 Property

Melting point:
128-129 °C
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear (warmed)
pka
14.09±0.46(Predicted)
form 
powder
color 
white to light brown
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A0862
Product name
A-740003
Purity
≥98% (HPLC)
Packaging
5mg
Price
$132
Updated
2024/03/01
Sigma-Aldrich
Product number
A0862
Product name
A-740003
Purity
≥98% (HPLC)
Packaging
25mg
Price
$530
Updated
2024/03/01
Sigma-Aldrich
Product number
5.08317
Product name
A740003 - CAS 861393-28-4 - Calbiochem
Packaging
5mg
Price
$166
Updated
2022/05/15
Cayman Chemical
Product number
21256
Product name
A-740003
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21256
Product name
A-740003
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
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A-740003 Chemical Properties,Usage,Production

Uses

A 740003 is a potent, selective and competitive P2X7 receptor antagonist.

General Description

A-740003 is a highly affine and selective P2X7 receptor antagonist and is best for the progression of a radiotracer for imaging of neuroinflammation by positron emission tomography.

Biological Activity

Potent, selective and competitive P2X 7 receptor antagonist (IC 50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μ M. Reduces nociception in animal models of persistent neuropathic and inflammatory pain.

Biochem/physiol Actions

A-740003 is a selective P2X7 purinoceptor antagonist.

storage

Store at +4°C

References

[1]. prisca honore, diana donnelly-roberts, marian t. namovic, et al. a-740003 [n-(1-{[(cyanoimino)(5-quinolinylamino)methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective p2x7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. journal of pharmacology and experimental therapeutics, 2006, 319:1376-1385.

A-740003 Preparation Products And Raw materials

Raw materials

Preparation Products

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861393-28-4, A-740003Related Search:


  • N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
  • A-740003 N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
  • N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide A-740003
  • N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide
  • A-740003, >=99%
  • (E)-N-(1-((Cyanamido(quinolin-5-ylamino)methylene)amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyp
  • A-740003
  • N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
  • N-[1-[(E)-[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
  • A740003 - CAS 861393-28-4 - Calbiochem
  • A 740003; A740003
  • CS-451
  • Benzeneacetamide, N-[1-[[(cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxy-
  • N-(1-(3-Cyano-2-(quinolin-5-yl)guanidino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide
  • P2XRs,P2X Receptor,inhibit,A-740003,A740003,Inhibitor
  • 861393-28-4