A-740003
- Product Name
- A-740003
- CAS No.
- 861393-28-4
- Chemical Name
- A-740003
- Synonyms
- CS-451;A-740003;A-740003, >=99%;A 740003; A740003;A740003 - CAS 861393-28-4 - Calbiochem;P2XRs,P2X Receptor,inhibit,A-740003,A740003,Inhibitor;(E)-N-(1-((Cyanamido(quinolin-5-ylamino)methylene)amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyp;N-(1-(3-Cyano-2-(quinolin-5-yl)guanidino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide;N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
- CBNumber
- CB61871931
- Molecular Formula
- C26H30N6O3
- Formula Weight
- 474.55
- MOL File
- 861393-28-4.mol
A-740003 Property
- Melting point:
- 128-129 °C
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear (warmed)
- pka
- 14.09±0.46(Predicted)
- form
- powder
- color
- white to light brown
N-Bromosuccinimide Price
- Product number
- A0862
- Product name
- A-740003
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $132
- Updated
- 2024/03/01
- Product number
- A0862
- Product name
- A-740003
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $530
- Updated
- 2024/03/01
- Product number
- 5.08317
- Product name
- A740003 - CAS 861393-28-4 - Calbiochem
- Packaging
- 5mg
- Price
- $166
- Updated
- 2022/05/15
- Product number
- 21256
- Product name
- A-740003
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21256
- Product name
- A-740003
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
A-740003 Chemical Properties,Usage,Production
Uses
A 740003 is a potent, selective and competitive P2X7 receptor antagonist.
General Description
A-740003 is a highly affine and selective P2X7 receptor antagonist and is best for the progression of a radiotracer for imaging of neuroinflammation by positron emission tomography.
Biological Activity
Potent, selective and competitive P2X 7 receptor antagonist (IC 50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μ M. Reduces nociception in animal models of persistent neuropathic and inflammatory pain.
Biochem/physiol Actions
A-740003 is a selective P2X7 purinoceptor antagonist.
storage
Store at +4°C
References
[1]. prisca honore, diana donnelly-roberts, marian t. namovic, et al. a-740003 [n-(1-{[(cyanoimino)(5-quinolinylamino)methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective p2x7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. journal of pharmacology and experimental therapeutics, 2006, 319:1376-1385.