ChemicalBook > CAS DataBase List > Trimethoprim-d3

Trimethoprim-d3

Product Name: Trimethoprim-d3
CAS No.: 1189923-38-3
Chemical Name: Trimethoprim-d3
Synonyms: Tiempe-d3;Uretrim-d3;Trimanyl-d3;Monotrim-d3;Instalac-d3;Syraprim-d3;Proloprim-d3;Wellcoprim-d3;Trimethoprim-d3;D3-Trimethoprim
CBNumber: CB61873470
Molecular Formula: C14H18N4O3
Formula Weight: 290.31772
MOL File: 1189923-38-3.mol

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Trimethoprim-d3 Property

Melting point:: 208-210°C
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

H401Toxic to aquatic life

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26119
Product name: Trimethoprim-d3
Purity: ≥99% deuterated forms (d1-d3)
Packaging: 500μg
Price: $178
Updated: 2024/03/01

Cayman Chemical

Product number: 26119
Product name: Trimethoprim-d3
Purity: ≥99% deuterated forms (d1-d3)
Packaging: 1mg
Price: $336
Updated: 2024/03/01

Usbiological

Product number: 022396
Product name: Trimethoprim-d3
Packaging: 1mg
Price: $446
Updated: 2021/12/16

TRC

Product number: T795618
Product name: Trimethoprim-d3
Packaging: 10mg
Price: $1295
Updated: 2021/12/16

AK Scientific

Product number: 7876DG
Product name: Trimethoprim-d3
Packaging: 1mg
Price: $472
Updated: 2021/12/16

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Trimethoprim-d3 Chemical Properties,Usage,Production

Description

Trimethoprim-d₃ is intended for use as an internal standard for the quantification of trimethoprim by GC- or LC-MS. Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid. Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC₅₀s = 5 and 30,000 nM, respectively). Formulations containing trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, have been used in the treatment of urinary tract infections.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Trimethoprim-d3 (Major) is an antibacterial.

Uses

Deuterated Trimethoprim, an antibacterial

References

[1] THANH LAM. Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines[J]. Journal of Medicinal Chemistry, 2014, 57 3: 651-668. DOI: 10.1021/jm401204g
[2] BARRY I. SCHWEITZER Joseph R B Adam P Dicker. Dihydrofolate reductase as a therapeutic target[J]. FASEB Journal, 1990, 4 8: 2441-2452. DOI: 10.1096/fasebj.4.8.2185970

Trimethoprim-d3 Preparation Products And Raw materials

Raw materials

Preparation Products

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1189923-38-3, Trimethoprim-d3Related Search:

Trimethoprim Trimethoprim tablets Sulfolex-13C6 SulfaMethoxazole-13C6 SULFAMETHAZINE (Phenyl-13C6, 99%)

2,4-Diamino-5-(3',4',5'-trimethoxy-d3-benzyl)pyrimidine

5-[(3,4,5-Trimethoxy-d3-phenyl)methyl]-2,4-pyrimidinediamine

Instalac-d3

Monotrim-d3

Proloprim-d3

Syraprim-d3

Tiempe-d3

Trimanyl-d3

Trimethoprim-d3

Uretrim-d3

Wellcoprim-d3

5-[(3,4,5-TriMethoxy-d3-phenyl)Methyl]-

5-[[3,5-dimethoxy-4-(trideuteriomethoxy)phenyl]methyl]pyrimidine-2,4-diamine

[2H3]-Trimethoprim

Trimethoprim-d3 (Major)

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Trimethoprim-d4 (Major)

Trimethoprim D3 (4-methoxy D3) 100 μg/mL in Acetonitrile

D3-Trimethoprim

1189923-38-3

C14H15D3N4O3

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Intermediates & Fine Chemicals

Isotope Labeled Compounds

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Isotope Labelled Compounds