ChemicalBook > CAS DataBase List > Reversan
Reversan
- Product Name
- Reversan
- CAS No.
- 313397-13-6
- Chemical Name
- Reversan
- Synonyms
- CBLC4H10;Reversan;N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(4-morpholinyl)propyl]-5,7-diphenyl-;5,7-Diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-morpholin-4-yl-propyl)-amide;ReversanQ: What is Reversan Q: What is the CAS Number of Reversan Q: What is the storage condition of Reversan Q: What are the applications of Reversan
- CBNumber
- CB61883226
- Molecular Formula
- C26H27N5O2
- Formula Weight
- 441.52
- MOL File
- 313397-13-6.mol
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Reversan Property
- Melting point:
- 176-180°C
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO: ≥8mg/mL at ~60°C
- pka
- 11.33±0.46(Predicted)
- form
- powder
- color
- faint yellow to yellow
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0173
- Product name
- Reversan
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $129
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0173
- Product name
- Reversan
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $519
- Updated
- 2024/03/01
Tocris
- Product number
- 3722
- Product name
- Reversan
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $952
- Updated
- 2021/12/16
Tocris
- Product number
- 3722
- Product name
- Reversan
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $227
- Updated
- 2021/12/16
Usbiological
- Product number
- 256447
- Product name
- Reversan
- Packaging
- 10mg
- Price
- $480
- Updated
- 2021/12/16
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Reversan Chemical Properties,Usage,Production
Uses
Reversan represents a new class of nontoxic MRP1 inhibitor, which may be clinically useful for the treatment of neuroblastoma.
Biological Activity
Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin , vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo . Displays at activity on MRP2, MRP3, MRP5 and MRP5 transporters.
storage
Store at -20°C
Reversan Preparation Products And Raw materials
Raw materials
Preparation Products
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Reversan Suppliers
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