5-Chloro-3-methylpyrazole
- Product Name
- 5-Chloro-3-methylpyrazole
- CAS No.
- 15953-45-4
- Chemical Name
- 5-Chloro-3-methylpyrazole
- Synonyms
- 5-CHLORO-3-METHYL-1H-PYRAZOLE;5-Chloro-3-methylpyrazole;3-Chloro-5-methylpyrazole;1H-Pyrazole, 3-chloro-5-methyl-;5-chloro-3-methyl-1H-pyrazole(SALTDATA: FREE)
- CBNumber
- CB6193599
- Molecular Formula
- C4H5ClN2
- Formula Weight
- 116.55
- MOL File
- 15953-45-4.mol
5-Chloro-3-methylpyrazole Property
- Melting point:
- 118.5°C
- Boiling point:
- 180.5°C (rough estimate)
- Density
- 1.2115 (rough estimate)
- refractive index
- 1.5320 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 11.60±0.10(Predicted)
- Appearance
- White to off-white Solid
- EPA Substance Registry System
- 1H-Pyrazole, 3-chloro-5-methyl- (15953-45-4)
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C373443
- Product name
- 5-chloro-3-methyl-1H-pyrazole
- Packaging
- 1g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- FC151277
- Product name
- 3-Chloro-5-methyl-1H-pyrazole
- Packaging
- 100mg
- Price
- $54
- Updated
- 2021/12/16
- Product number
- 3H32-5-AX
- Product name
- 5-Chloro-3-methylpyrazole
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC151277
- Product name
- 3-Chloro-5-methyl-1H-pyrazole
- Packaging
- 250mg
- Price
- $107.5
- Updated
- 2021/12/16
- Product number
- OR917576
- Product name
- 5-Chloro-3-methylpyrazole
- Purity
- 95%
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
5-Chloro-3-methylpyrazole Chemical Properties,Usage,Production
Synthesis
54454-10-3
15953-45-4
General procedure for the synthesis of 5-chloro-3-methylpyrazole from 5-chloro-1,3-dimethyl-1H-pyrazole: (a) 5-chloro-1,3-dimethylpyrazole (2.6 mmol) and pyridine hydrochloride (13.1 mmol) were placed in a sealed 5 mL process vial, and the mixture was heated by microwave radiation for 2 hr at 200 °C. After completion of the reaction, it was cooled to room temperature, ethyl acetate (15 mL) was added, the mixture was washed sequentially with 2 M aqueous hydrochloric acid (10 mL) and saturated aqueous sodium chloride, dried over anhydrous magnesium sulphate and concentrated to give the title compound 5-chloro-3-methylpyrazole as a white solid (yield: 210 mg, 67%). Mass spectrometry (MS) showed molecular ion peak (M+H) m/z = 117. 1H-NMR (DMSO-d6, 400 MHz) data: δ 12.66 (broad single peak, 1H), 6.03 (multiple peaks, 1H), 2.19 (single peak, 3H).
References
[1] Patent: WO2007/45868, 2007, A1. Location in patent: Page/Page column 50
[2] Patent: WO2007/51981, 2007, A1. Location in patent: Page/Page column 47-48
[3] Patent: WO2006/32851, 2006, A1. Location in patent: Page/Page column 41-42
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 15, p. 3024 - 3029
[5] Patent: WO2008/129280, 2008, A1. Location in patent: Page/Page column 46
5-Chloro-3-methylpyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
5-Chloro-3-methylpyrazole Suppliers
- Tel
- --
- Fax
- --
- info@specs.net
- Country
- The Netherlands
- ProdList
- 6833
- Advantage
- 70
View Lastest Price from 5-Chloro-3-methylpyrazole manufacturers
- Product
- 5-Chloro-3-methylpyrazole 15953-45-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-08