4-PIPERIDIN-1-YL-BENZOIC ACID
- Product Name
- 4-PIPERIDIN-1-YL-BENZOIC ACID
- CAS No.
- 22090-24-0
- Chemical Name
- 4-PIPERIDIN-1-YL-BENZOIC ACID
- Synonyms
- AKOS B022044;BUTTPARK 99\50-11;CHEMBRDG-BB 4400214;ART-CHEM-BB B022044;TIMTEC-BB SBB007144;OTAVA-BB BB5300270010;4-PIPERIDINOBENZOIC ACID;4-(1-piperidinyl)benzoate;4-(1-piperidyl)benzoic acid;1-(4-Carboxyphenyl)piperidine
- CBNumber
- CB6199915
- Molecular Formula
- C12H15NO2
- Formula Weight
- 205.25
- MOL File
- 22090-24-0.mol
4-PIPERIDIN-1-YL-BENZOIC ACID Property
- Melting point:
- 222-224 °C(Solv: benzene (71-43-2))
- Boiling point:
- 388.9±25.0 °C(Predicted)
- Density
- 1.178±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 3.65±0.10(Predicted)
- color
- Pink
- CAS DataBase Reference
- 22090-24-0(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- 010127
- Product name
- 4-Piperidinobenzenecarboxylic acid
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- OR0759
- Product name
- 4-(Piperidin-1-yl)benzoicacid
- Packaging
- 100mg
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 4H21-1-E1
- Product name
- 4-(Piperidin-1-yl)benzoic acid
- Packaging
- 100mg
- Price
- $16
- Updated
- 2021/12/16
- Product number
- 010127
- Product name
- 4-Piperidinobenzenecarboxylic acid
- Packaging
- 500mg
- Price
- $16
- Updated
- 2021/12/16
- Product number
- OR0759
- Product name
- 4-(Piperidin-1-yl)benzoicacid
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
4-PIPERIDIN-1-YL-BENZOIC ACID Chemical Properties,Usage,Production
Definition
ChEBI: 4-Piperidinobenzoic acid is a member of piperidines.
Synthesis
1204-85-9
22090-24-0
Example 113 Steps for the synthesis of 10-(4-piperidin-1-ylbenzoyl)-N-(pyridin-3-ylmethyl)-10,11-dihydro-5H-pyrrolo[2,1-C][1,4]benzodiazine-3-carboxamide A. Preparation of 4-piperidin-1-ylbenzylcarbonitrile: Under nitrogen protection, 4-fluorobenzylcarbonitrile (1 g, 8.26 mmol), piperidine (0.90 mL, 9.08 mmol), piperidine (0.90 mL, 9.08 mmol) and anhydrous potassium carbonate (2.28 g, 16.51 mmol) were dissolved in anhydrous 1-methyl-2-pyrrolidinone (10 mL), and the reaction was stirred for 20 h at 120°C. The reaction was carried out under nitrogen protection. After completion of the reaction, the mixture was cooled to room temperature, diluted with water (100 mL) and extracted with ethyl acetate (100 mL). The organic phases were combined, washed sequentially with water (100 mL) and saturated saline (100 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give an orange oily crude product. It was purified by fast column chromatography using a gradient elution of hexane with ethyl acetate (1% to 7%) to give the orange oily product, which was further crystallized from hexane to give 4-(1-piperidinyl)benzonitrile (1.41 g, 92% yield) as an orange crystalline solid with a melting point of 54°C. Mass spectrum ((+)ESI, m/z): 187 [M+H]+. Elemental analysis (C12H14N2) Calculated values: C, 77.38; H, 7.58; N, 15.04. Measured values: C, 77.30; H, 7.41; N, 15.06.
References
[1] Patent: US2006/287522, 2006, A1. Location in patent: Page/Page column 54
[2] Journal of the American Chemical Society, 1940, vol. 62, p. 2995,3001
[3] Molecular Crystals and Liquid Crystals (1969-1991), 1985, vol. 124, p. 269 - 276
4-PIPERIDIN-1-YL-BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-PIPERIDIN-1-YL-BENZOIC ACID manufacturers
- Product
- 4-PIPERIDIN-1-YL-BENZOIC ACID 22090-24-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-19