Z-PHE-ALA-OH

Product Name: Z-PHE-ALA-OH
CAS No.: 21881-18-5
Chemical Name: Z-PHE-ALA-OH
Synonyms: Z-PHE-ALA;Z-PHE-ALA-OH;CBZ-L-PHE-ALA;N-CBZ-PHE-ALA;Cbz-Phe-Ala-OH;CBZ-L-PHE-L-ALA;Cbz-L-Phe-L-Ala-OH;Z-PHE-ALA-OH USP/EP/BP;N-carbobenzyloxy-Phe-Ala;Z-Phe-Ala-OH≥ 99% (HPLC)
CBNumber: CB6204765
Molecular Formula: C20H22N2O5
Formula Weight: 370.4
MOL File: 21881-18-5.mol

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Z-PHE-ALA-OH Property

Melting point:: 151-154 °C
storage temp.: Sealed in dry,2-8°C
solubility: methanol: ~50mg/mL, almost clear, almost colorless
Boiling point:: 666.1±55.0 °C(Predicted)
Density: 1.253±0.06 g/cm3(Predicted)
pka: 3.50±0.10(Predicted)
form: powder

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Safety

Safety Statements: 22-24/25

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: 287803
Product name: Z-Phe-Ala-OH
Packaging: 2g
Price: $343
Updated: 2021/12/16

TRC

Product number: P998453
Product name: Z-Phe-Ala-OH
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 094129
Product name: Z-Phe-Ala
Purity: 95+%
Packaging: 5g
Price: $252
Updated: 2021/12/16

Matrix Scientific

Product number: 094129
Product name: Z-Phe-Ala
Purity: 95+%
Packaging: 10g
Price: $395
Updated: 2021/12/16

Chem-Impex

Product number: 05219
Product name: Z-Phe-Ala-OH,99%(HPLC)
Purity: 99%(HPLC)
Packaging: 25G
Price: $440.16
Updated: 2021/12/16

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Z-PHE-ALA-OH Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Sensitive substrate for cathepsin A.

Synthesis

3397-32-8

56-41-7

3338-39-4

The general procedure for the synthesis of the compound (CAS:3338-39-4) from (S)-2,5-dioxopyrrolidin-1-yl 2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate and L-alanine was as follows: with reference to the method of Itoh [M. Itoh, Chem. Pharm. Bull., 20, 664 (1972)], to L- alanine (18 mmol, 1.60 g) dissolved in 200 mL of a 1:1 dioxane-water mixture to triethylamine (36 mmol, 5.0 mL). Solid carbon dioxide tablets were added under stirring conditions until the solution pH reached 8. Subsequently, N-Benzyloxycarbonyl-L-phenylalanine N-hydroxysuccinimide ester (18 mmol, 7.13 g) was added under stirring at room temperature. After 16-20 hours of reaction, the reaction mixture was acidified by slow addition of 1N HCl followed by extraction with ethyl acetate. The organic phase was separated, washed sequentially with water (twice) and brine, dried over MgSO4, concentrated by rotary evaporation and dried under high vacuum to give 6.19 g (93% yield) of N-Benzyloxycarbonyl-L-phenylalanyl-L-alanine as a white solid with a melting point of 160-164 °C (literature value: 165 °C; G.R. Pettit, 'Synthetic Peptides', Vol. 1, p. 141 (1970)). Using similar methods, the following compounds of formula (2) can be prepared according to the procedure described in Preparation 1.

References

[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6230 - 6237
[2] Patent: US5055451, 1991, A
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 3, p. 1071 - 1078

Z-PHE-ALA-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-PHE-ALA-OH Suppliers

China 79 India 2 Switzerland 2 United States 14 Global 97

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View Lastest Price from Z-PHE-ALA-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Cbz-Phe-Ala-OH 21881-18-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-19

21881-18-5, Z-PHE-ALA-OHRelated Search:

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CBZ-L-PHE-ALA

CBZ-L-PHE-L-ALA

Z-PHE-ALA-OH

Z-PHE-ALA

Z-L-PHENYLALANYL-L-ALANINE

N-CBZ-PHE-ALA

N-CARBOBENZOXY-L-PHENYLALANYL-L-ALANINE

N-BENZYLOXYCARBONYL-L-PHENYLALANYL-L-ALANINE

N-carbobenzyloxy-Phe-Ala

N-Cbz-Phe-Ala, Z-L-phenylalanyl-L-alanine

Cbz-L-Phe-L-Ala-OH

Z-Phe-Ala-OH≥ 99% (HPLC)

(S)-2-((S)-2-(((Benzyloxy)carbonyl)aMino)-3-phenylpropanaMido)propanoic acid

Cbz-Phe-Ala-OH

L-Alanine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-

Z-PHE-ALA-OH USP/EP/BP

N-Cbz-L-phenylalanyl-L-alanine

(S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoic acid - [B91595]

21881-18-5

C6H5CH2CHNHCOOCH2C6H5CONHCHCH3COOH

Amino Acid Derivatives