ChemicalBook > CAS DataBase List > 2-Ethoxybenzonitrile

2-Ethoxybenzonitrile

Product Name
2-Ethoxybenzonitrile
CAS No.
6609-57-0
Chemical Name
2-Ethoxybenzonitrile
Synonyms
Ethoxybenzonitril;O-ETHOXYBENZONITRILE;2-ETHOXYBENZONITRILE;2-Ethoxybenzonitrile>Benzonitrile, 2-ethoxy-;O-ETHOXYBENZONITRILE 95%;2-ETHOXYBENZONITRILE 98%;2-Ethoxybenzonitrile o-Ethoxybenzonitrile
CBNumber
CB6205010
Molecular Formula
C9H9NO
Formula Weight
147.17
MOL File
6609-57-0.mol
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2-Ethoxybenzonitrile Property

Melting point:
5°C(lit.)
Boiling point:
154°C 20mm
Density 
1.053 g/mL at 25 °C (lit.)
vapor pressure 
0.49-54000Pa at 20-238℃
refractive index 
n20/D 1.5322(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
form 
Liquid
color 
Clear colorless to pale yellow
LogP
2.6 at 25℃ and pH6.6
Surface tension
54.5mN/m at 511.2mg/L and 20.1℃
CAS DataBase Reference
6609-57-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-37/39
RIDADR 
UN3276
WGK Germany 
2
HazardClass 
6.1
PackingGroup 
III
HS Code 
29269095
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
283576
Product name
2-Ethoxybenzonitrile
Purity
98%
Packaging
1g
Price
$93.6
Updated
2023/01/07
TCI Chemical
Product number
E0968
Product name
2-Ethoxybenzonitrile
Purity
>98.0%(GC)
Packaging
5g
Price
$35
Updated
2025/07/31
TCI Chemical
Product number
E0968
Product name
2-Ethoxybenzonitrile
Purity
>98.0%(GC)
Packaging
25g
Price
$107
Updated
2025/07/31
TRC
Product number
E891333
Product name
2-Ethoxybenzonitrile
Packaging
250mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
003296
Product name
2-Ethoxybenzonitrile
Purity
98%
Packaging
25g
Price
$53
Updated
2021/12/16
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2-Ethoxybenzonitrile Chemical Properties,Usage,Production

Uses

2-Ethoxybenzonitrile has been used in the synthesis of selective phosphodiesterase(V) inhibitor, vardenafil.

Synthesis

64-67-5

611-20-1

6609-57-0

To a 250 mL three-necked flask was added 5.95 g (0.05 mol) of o-hydroxybenzonitrile, 20 mL of 10% aqueous NaOH and 80 mL of toluene and the mixture was heated to 70 °C and maintained at this temperature for 1 hour of reaction. Subsequently, the temperature was lowered to 60 °C and 9.24 g of diethyl sulfate was slowly added dropwise. After the dropwise addition, the reaction temperature was raised to 70 °C and the reaction was continued for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) until o-hydroxybenzonitrile completely disappeared. After completion of the reaction, the mixture was cooled to room temperature and liquid-liquid separation was carried out. The toluene layer was collected and the solvent was removed by evaporation to give a light yellow oily liquid 2-ethoxybenzonitrile 6.98 g in 95% yield.

References

[1] Patent: CN108440519, 2018, A. Location in patent: Paragraph 0021; 0022; 0023; 0024
[2] Patent: CN108341808, 2018, A. Location in patent: Paragraph 0021; 0022; 0023

2-Ethoxybenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Ethoxybenzonitrile Suppliers

Americas 1 Belgium 2 China 117 Europe 3 France 1 Germany 3 India 19 Japan 3 Switzerland 2 Ukraine 1 United Kingdom 15 United States 31 Global 198
J & K SCIENTIFIC LTD.
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View Lastest Price from 2-Ethoxybenzonitrile manufacturers

Career Henan Chemical Co
Product
2-Ethoxybenzonitrile 6609-57-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%HPLC
Supply Ability
10 tons/month
Release date
2020-01-07

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  • 2-ETHOXYBENZONITRILE
  • O-ETHOXYBENZONITRILE
  • 2-Ethoxybenzonitrile o-Ethoxybenzonitrile
  • 2-ETHOXYBENZONITRILE 98%
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  • 6609-57-0
  • C2H5OC6H4CN
  • C8 to C9
  • Building Blocks
  • Nitrogen Compounds
  • Organic Building Blocks
  • Cyanides/Nitriles
  • Building Blocks
  • C8 to C9
  • Chemical Synthesis
  • Nitrogen Compounds
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  • Aromatic Nitriles
  • API intermediates
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  • C8 to C9
  • Cyanides/Nitriles
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